Search Results - "Zachary B. Mackey"

Early invasion of brain parenchyma by African trypanosomes by Frevert, Ute, Movila, Alexandru, Nikolskaia, Olga V, Raper, Jayne, Mackey, Zachary B, Abdulla, Maha, McKerrow, James, Grab, Dennis J

“…Human African trypanosomiasis or sleeping sickness is a vector-borne parasitic disease that has a major impact on human health and welfare in sub-Saharan…”
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Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei by Kerr, Iain D, Wu, Peng, Marion-Tsukamaki, Rachael, Mackey, Zachary B, Brinen, Linda S

“…Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the…”
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Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei by Sanchez, Laura M, Knudsen, Giselle M, Helbig, Claudia, De Muylder, Geraldine, Mascuch, Samantha M, Mackey, Zachary B, Gerwick, Lena, Clayton, Christine, McKerrow, James H, Linington, Roger G

“…Almiramide C is a marine natural product with low micromolar activity against Leishmania donovani, the causative agent of leishmaniasis. We have now shown that…”
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A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition by O'Brien, Theresa C., Mackey, Zachary B., Fetter, Richard D., Choe, Youngchool, O'Donoghue, Anthony J., Zhou, Min, Craik, Charles S., Caffrey, Conor R., McKerrow, James H.

“…Cysteine proteases of the Clan CA (papain) family are the predominant protease group in primitive invertebrates. Cysteine protease inhibitors arrest infection…”
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RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model by Abdulla, Maha-Hamadien, O'Brien, Theresa, Mackey, Zachary B, Sajid, Mohamed, Grab, Dennis J, McKerrow, James H

“…We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an…”
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A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM‐binding pocket of proliferating cell nuclear antigen orthologs by Actis, Marisa, Fujii, Naoaki, Mackey, Zachary B.

“…Proliferating cell nuclear antigen (PCNA) is a homo‐trimeric protein complex that clamps around DNA to tether DNA polymerases to the template during…”
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A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei by Mackey, Zachary B, O'Brien, Theresa C, Greenbaum, Doron C, Blank, Rebecca B, McKerrow, James H

“…Identification and analysis of Clan CA (papain) cysteine proteases in primitive protozoa and metazoa have suggested that this enzyme family is more diverse and…”
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Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit by Chen, Chiung-Kuang, Doyle, Patricia S, Yermalitskaya, Liudmila V, Mackey, Zachary B, Ang, Kenny K H, McKerrow, James H, Podust, Larissa M

“…The two front-line drugs for chronic Trypanosoma cruzi infections are limited by adverse side-effects and declining efficacy. One potential new target for…”
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Mining a cathepsin inhibitor library for new antiparasitic drug leads by Ang, Kenny K H, Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B, Skrzypczynska, Katarzyna M, Debnath, Anjan, Engel, Juan C, Rosenthal, Philip J, McKerrow, James H, Arkin, Michelle R, Renslo, Adam R

“…The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping…”
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CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement by Liu, Gongguan, Fu, Yong, Yosri, Mohammed, Chen, Yanli, Sun, Peng, Xu, Jinjun, Zhang, Mingshun, Sun, Donglei, Strickland, Ashley B., Mackey, Zachary B., Shi, Meiqing

“…Although CRIg was originally identified as a macrophage receptor for binding complement C3b/iC3b in vitro, recent studies reveal that CRIg functions as a…”
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Depletion of the extracellular-signal regulated kinase 8 homolog in Trypanosoma brucei in vivo reduces its virulence in a mouse target validation study by Elaadli, Haitham, Kim, Inyoung, Mackey, Zachary B.

“…[Display omitted] •Depletion of TbERK8 in Trypanosoma brucei reduces its virulence in mouse infection.•TbERK8 is linked to processes involved in T. brucei…”
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Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii by Liu, Chao-Lin, Shen, Chia-Rui, Hsu, Fong-Fu, Chen, Jeen-Kuan, Wu, Pei-Tzu, Guo, Shang-Hsin, Lee, Wen-Chien, Yu, Feng-Wei, Mackey, Zachary B., Turk, John, Gross, Michael L.

“…Two SDS‐resistant endochitinases, designated as ASCHI53 and ASCHI61, were isolated from Aeromonas schubertii in a soil sample from southern Taiwan. MALDI‐TOF…”
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Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties by Valenciano, Ana L, Knudsen, Giselle M, Mackey, Zachary B

“…The Trypanosoma brucei subspecies T. brucei gambiense and T. brucei rhodesiense are vector-borne pathogens that cause sleeping sickness also known as Human…”
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Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor by Valenciano, Ana L., Ramsey, Aaron C., Santos, Webster L., Mackey, Zachary B.

“…[Display omitted] •The first series of Trypanosoma brucei bioactive TbERK8 inhibitors have been identified.•AZ960 selectively inhibits T. brucei ERK8 but not…”
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Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression by Valenciano, Ana L, Ramsey, Aaron C, Mackey, Zachary B

“…The DNA replication machinery is spatially and temporally coordinated in all cells to reproduce a single exact copy of the genome per division, but its…”
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High-Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei by Mackey, Zachary B., Koupparis, Kyriacos, Nishino, Mari, McKerrow, James H.

“…New drugs are needed to treat human African trypanosomiasis because the currently approved treatments are toxic or limited in efficacy. One strategy for…”
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Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair by Leppard, John B., Dong, Zhiwan, Mackey, Zachary B., Tomkinson, Alan E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Discovery of Trypanocidal Compounds by Whole Cell HTS of Trypanosoma brucei by Mackey, Zachary B., Baca, Arthur M., Mallari, Jeremy P., Apsel, Beth, Shelat, Anang, Hansell, Elizabeth J., Chiang, Peter K., Wolff, Brian, Guy, Kiplin R., Williams, Janice, McKerrow, James H.

“…Chemotherapy against human African trypanosomiasis relies on four drugs that cause frequent and occasionally severe side‐effects. Because human African…”
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Drugs targeting parasite lysosomes by Doyle, Patricia S, Sajid, Mohamed, O'Brien, Theresa, Dubois, Kelly, Engel, Juan C, Mackey, Zachary B, Reed, Sharon

“…Lysosomes were first described as vacuolar structures containing various hydrolytic enzymes at acidic pH. Subsequent studies revealed that the…”
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An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei by Li, Ziyin, Zou, Chun-Bin, Yao, Yi, Hoyt, Martin A, McDonough, Stephen, Mackey, Zachary B, Coffino, Philip, Wang, Ching C

“…The 26 S proteasome, a complex between the 20 S proteasome and 19 S regulatory units, catalyzes ATP-dependent degradation of unfolded and ubiquitinated…”
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