Search Results - "Zachary, Ian C"

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation by Herzog, Birger, Pellet-Many, Caroline, Britton, Gary, Hartzoulakis, Basil, Zachary, Ian C

“…In endothelial cells, neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF)-A and is thought to act as a coreceptor for kinase insert…”
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Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling by Bubb, Kristen J., Aubdool, Aisah A., Moyes, Amie J., Lewis, Sarah, Drayton, Jonathan P., Tang, Owen, Mehta, Vedanta, Zachary, Ian C., Abraham, David J., Tsui, Janice, Hobbs, Adrian J.

“…BACKGROUND:Angiogenesis and vascular remodeling are complementary, innate responses to ischemic cardiovascular events, including peripheral artery disease and…”
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Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas by Pellet-Many, Caroline, Frankel, Paul, Evans, Ian M, Herzog, Birger, Jünemann-Ramírez, Manfred, Zachary, Ian C

“…NRP1 (neuropilin-1) is a co-receptor for members of the VEGF (vascular endothelial growth factor) family in endothelial cells, but is increasingly implicated…”
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Neuropilin 1 is essential for gastrointestinal smooth muscle contractility and motility in aged mice by Yamaji, Maiko, Mahmoud, Marwa, Evans, Ian M, Zachary, Ian C

“…Neuropilin 1 (NRP1) is a non-tyrosine kinase receptor for vascular endothelial growth factor (VEGF) and class 3 semaphorins, playing a role in angiogenesis and…”
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Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis by Bruns, Alexander F, Herbert, Shane P, Odell, Adam F, Jopling, Helen M, Hooper, Nigel M, Zachary, Ian C, Walker, John H, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor A (VEGF-A)-induced signaling through VEGF receptor 2 (VEGFR2) regulates both physiological and pathological angiogenesis in…”
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Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase by Evans, Ian M., Britton, Gary, Zachary, Ian C.

“…Proteomic analysis identified HSP27 phosphorylation as a major change in protein phosphorylation stimulated by Vascular Endothelial Growth Factor (VEGF) in…”
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Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking by Critchley, William R, Pellet-Many, Caroline, Ringham-Terry, Benjamin, Harrison, Michael A, Zachary, Ian C, Ponnambalam, Sreenivasan

“…Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that…”
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A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair by Bruns, Alexander F, Yuldasheva, Nadira, Latham, Antony M, Bao, Leyuan, Pellet-Many, Caroline, Frankel, Paul, Stephen, Sam L, Howell, Gareth J, Wheatcroft, Stephen B, Kearney, Mark T, Zachary, Ian C, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and…”
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Intrinsic Tyrosine Kinase Activity is Required for Vascular Endothelial Growth Factor Receptor 2 Ubiquitination, Sorting and Degradation in Endothelial Cells by Ewan, Lorna C., Jopling, Helen M., Jia, Haiyan, Mittar, Shweta, Bagherzadeh, Azadeh, Howell, Gareth J., Walker, John H., Zachary, Ian C., Ponnambalam, Sreenivasan

“…The human endothelial vascular endothelial growth factor receptor 2 (VEGFR2/kinase domain region, KDR/fetal liver kinase‐1, Flk‐1) tyrosine kinase receptor is…”
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Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation by KHURANA, Rohit, MOONS, Lieve, SHAFI, Shahida, LUTTUN, Aernout, COLLEN, Désiré, MARTIN, John F, CARMELIET, Peter, ZACHARY, Ian C

“…Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease,…”
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Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells by Evans, Ian M, Bagherzadeh, Azadeh, Charles, Mark, Raynham, Tony, Ireson, Chris, Boakes, Alexandra, Kelland, Lloyd, Zachary, Ian C

“…VEGF (vascular endothelial growth factor) plays an essential role in angiogenesis during development and in disease largely mediated by signalling events…”
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Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells by Jopling, Helen M, Odell, Adam F, Hooper, Nigel M, Zachary, Ian C, Walker, John H, Ponnambalam, Sreenivasan

“…OBJECTIVE—Vascular endothelial growth factor receptor 2 (VEGFR2) is a receptor tyrosine kinase that regulates vascular physiology. However, mechanism(s) by…”
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Protein kinase D in vascular biology and angiogenesis by Evans, Ian M., Zachary, Ian C.

“…The Protein Kinase D (PKD) family comprises diacylglycerol stimulated serine/threonine protein kinases that participate in many key signaling pathways in a…”
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Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR Signaling by Jia, Haiyan, Bagherzadeh, Azadeh, Hartzoulakis, Basil, Jarvis, Ashley, Löhr, Marianne, Shaikh, Shaheda, Aqil, Rehan, Cheng, Lili, Tickner, Michelle, Esposito, Diego, Harris, Richard, Driscoll, Paul C., Selwood, David L., Zachary, Ian C.

“…Neuropilin-1 (NP-1) is a receptor for vascular endothelial growth factor-A165 (VEGF-A165) in endothelial cells. To define the role of NP-1 in the biological…”
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The role of neuropilins in cell signalling by Zachary, Ian C, Frankel, Paul, Evans, Ian M, Pellet-Many, Caroline

“…NRPs (neuropilins) are receptors for class 3 semaphorins, polypeptides essential for axonal guidance, and for members of the VEGF (vascular endothelial growth…”
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VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis by Fearnley, Gareth W, Smith, Gina A, Abdul-Zani, Izma, Yuldasheva, Nadira, Mughal, Nadeem A, Homer-Vanniasinkam, Shervanthi, Kearney, Mark T, Zachary, Ian C, Tomlinson, Darren C, Harrison, Michael A, Wheatcroft, Stephen B, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate…”
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Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation by Jopling, Helen M, Odell, Adam F, Pellet-Many, Caroline, Latham, Antony M, Frankel, Paul, Sivaprasadarao, Asipu, Walker, John H, Zachary, Ian C, Ponnambalam, Sreenivasan

“…Rab GTPases are implicated in endosome-to-plasma membrane recycling, but how such membrane traffic regulators control vascular endothelial growth factor…”
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How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns by Zachary, Ian C

“…Essential roles of NRP1 (neuropilin-1) in cardiovascular development and in neuronal axon targeting during embryogenesis are thought to be mediated primarily…”
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The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function by Critchley, William R, Smith, Gina A, Zachary, Ian C, Harrison, Michael A, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that…”
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E2 ubiquitin-conjugating enzymes, UBE2D1 and UBE2D2, regulate VEGFR2 dynamics and endothelial function by Critchley, William R, Smith, Gina A, Zachary, Ian C, Harrison, Michael A, Ponnambalam, Sreenivasan

“…Vascular endothelial growth factor receptor 2 (VEGFR2) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination which programs this…”
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