Search Results - "Zachar, Rikke"

Physiology and pathophysiology of the plasminogen system in the kidney by Svenningsen, Per, Hinrichs, Gitte Rye, Zachar, Rikke, Ydegaard, Rikke, Jensen, Boye L.

“…The plasminogen system is important for fibrinolysis in addition to tissue remodeling and inflammation with significance for kidney disease. The system…”
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The epithelial sodium channel γ-subunit is processed proteolytically in human kidney by Zachar, Rikke M, Skjødt, Karsten, Marcussen, Niels, Walter, Steen, Toft, Anja, Nielsen, Maria R, Jensen, Boye L, Svenningsen, Per

“…The epithelial sodium channel (ENaC) of the kidney is necessary for extracellular volume homeostasis and normal arterial BP. Activity of ENaC is enhanced by…”
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Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel by Zachar, Rikke, Thiel, Steffen, Hansen, Søren, Henriksen, Maiken Lumby, Skjoedt, Mikkel-Ole, Skjodt, Karsten, Hamzaei, Zohra, Madsen, Kirsten, Lund, Lars, Hummler, Edith, Svenningsen, Per, Jensen, Boye Lagerbon

“…Proteolytic activation of the renal epithelial sodium channel (ENaC) is increased by aldosterone. The aldosterone-sensitive protease remains unidentified. In…”
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Proteolytic activation of the epithelial sodium channel, ENaC in preeclampsia examined with urinary exosomes by Nielsen, Maria R, Hansen, Mie R, Frederiksen-Møller, Britta, Svenningsen, Per, Zachar, Rikke M, Jørgensen, Jan S, Jensen, Boye L

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249-POS by Nielsen, Maria Ravn, Rytz, Mie, Frederiksen-Møller, Britta, Svenningsen, Per, Zachar, Rikke M, Jørgensen, Jan Stener, Jensen, Boye Lagerbon

“…Objectives Increased activity of the epithelial sodium channel (ENaC) in the kidneys may explain the coupling between proteinuria, edema, suppressed…”
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Dietary Na + intake in healthy humans changes the urine extracellular vesicle prostasin abundance while the vesicle excretion rate, NCC, and ENaC are not altered by Zachar, Rikke, Jensen, Boye L, Svenningsen, Per

“…Low Na intake activates aldosterone signaling, which increases renal Na reabsorption through increased apical activity of the NaCl cotransporter (NCC) and the…”
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ACE2 and TMPRSS2 in human kidney tissue and urine extracellular vesicles with age, sex, and COVID-19 by Bach, Marie Lykke, Laftih, Sara, Andresen, Jesper K, Pedersen, Rune M, Andersen, Thomas Emil, Madsen, Lone W, Madsen, Kirsten, Hinrichs, Gitte R, Zachar, Rikke, Svenningsen, Per, Lund, Lars, Johansen, Isik S, Hansen, Lennart Friis, Palarasah, Yaseelan, Jensen, Boye L

“…SARS-CoV-2 virus infects cells by engaging with ACE2 requiring protease TMPRSS2. ACE2 is highly expressed in kidneys. Predictors for severe disease are high…”
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The epithelial Na+ channel α- and γ-subunits are cleaved at predicted furin-cleavage sites, glycosylated and membrane associated in human kidney by Zachar, Rikke, Mikkelsen, Maiken K., Skjødt, Karsten, Marcussen, Niels, Zamani, Reza, Jensen, Boye L., Svenningsen, Per

“…The epithelial Na + channel (ENaC) is essential for Na + /K + homeostasis and blood pressure control. Its activity is regulated by proteases in rodents. To…”
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Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel by Hinrichs, Gitte R, Michelsen, Jannie S, Zachar, Rikke, Friis, Ulla G, Svenningsen, Per, Birn, Henrik, Bistrup, Claus, Jensen, Boye L

“…Albuminuria predicts adverse renal outcome in kidney transplant recipients. The present study addressed the hypothesis that albuminuria is associated with…”
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Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients by Isaksson, Gustaf L, Nielsen, Marie B, Hinrichs, Gitte R, Krogstrup, Nicoline V, Zachar, Rikke, Stubmark, Heidi, Svenningsen, Per, Madsen, Kirsten, Bistrup, Claus, Jespersen, Bente, Birn, Henrik, Palarasah, Yaseelan, Jensen, Boye L

“…Proteinuria predicts accelerated decline in kidney function in kidney transplant recipients (KTRs). We hypothesized that aberrant filtration of complement…”
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Urine exosomes from healthy and hypertensive pregnancies display elevated level of α-subunit and cleaved α- and γ-subunits of the epithelial sodium channel—ENaC by Nielsen, Maria R., Frederiksen-Møller, Britta, Zachar, Rikke, Jørgensen, Jan S., Hansen, Mie R., Ydegaard, Rikke, Svenningsen, Per, Buhl, Kristian, Jensen, Boye L.

“…Preeclampsia is characterized by hypertension, proteinuria, suppression of plasma renin-angiotensin-aldosterone, and impaired urine sodium excretion…”
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The Epithelial Sodium Channel (ENaC) α‐ and γ‐subunits are cleaved by furin in human kidney by Langkilde, Rikke Zachar, Mikkelsen, Maiken Krogsbæk, Skjødt, Karsten, Zamani, Reza, Marcussen, Niels, Jensen, Boye, Svenningsen, Per

“…Abstract only The aldosterone‐sensitive Epithelial Sodium Channel (ENaC) plays an essential role in sodium homeostasis and blood pressure regulation. In vitro…”
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Urine exosomes from healthy and hypertensive pregnancies display elevated level of [alpha]-subunit and cleaved [alpha]- and [gamma]-subunits of the epithelial sodium channel--ENaC by Nielsen, Maria R, Frederiksen-møller, Britta, Zachar, Rikke, Jørgensen, Jan S, Hansen, Mie R, Ydegaard, Rikke, Svenningsen, Per, Buhl, Kristian, Jensen, Boye L

“…Preeclampsia is characterized by hypertension, proteinuria, suppression of plasma renin-angiotensin-aldosterone, and impaired urine sodium excretion…”
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Proteolytic processing of epithelial sodium channels by prostasin in human kidneys by Zachar, Rikke Meldgaard, Svenningsen, Per, Marcussen, Niels, Walter, Steen, Skjoedt, Karsten, Jensen, Boye L

“…Abstract only ENaC activity is regulated by proteolysis of γENaC. Prostasin is believed to be a relevant protease‐candidate and aldosterone is thought to…”
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[249-POS]: Proteolytic activation of the epithelial sodium channel ENaC in preeclampsia examined with urinary exosomes by Nielsen, Maria Ravn, Rytz, Mie, Frederiksen-Møller, Britta, Svenningsen, Per, Zachar, Rikke M., Jørgensen, Jan Stener, Jensen, Boye Lagerbon

“…Increased activity of the epithelial sodium channel (ENaC) in the kidneys may explain the coupling between proteinuria, edema, suppressed aldosterone and…”
Get full text