Search Results - "Zacconi, Flavia C."

Small interfering RNA for cancer treatment: overcoming hurdles in delivery by Charbe, Nitin Bharat, Amnerkar, Nikhil D., Ramesh, B., Tambuwala, Murtaza M., Bakshi, Hamid A., Aljabali, Alaa A.A., Khadse, Saurabh C., Satheeshkumar, Rajendran, Satija, Saurabh, Metha, Meenu, Chellappan, Dinesh Kumar, Shrivastava, Garima, Gupta, Gaurav, Negi, Poonam, Dua, Kamal, Zacconi, Flavia C.

“…In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and…”
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Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) Prepared by Microwave and Ultrasound-Assisted Synthesis: Promising Green Strategies for the Nanoworld by López, Karla L, Ravasio, Andrea, González-Aramundiz, José Vicente, Zacconi, Flavia C

“…Many pharmaceutically active molecules are highly lipophilic, which renders their administration and adsorption in patients extremely challenging. Among the…”
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Substitution Effects in Aryl Halides and Amides into the Reaction Mechanism of Ullmann-Type Coupling Reactions by Durán, Rocío, Barrales-Martínez, César, Santana-Romo, Fabián, Rodríguez, Diego F, Zacconi, Flavia C, Herrera, Barbara

“…In this article, we present a comprehensive computational investigation into the reaction mechanism of -arylation of substituted aryl halides through…”
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Innovative Three-Step Microwave-Promoted Synthesis of N -Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation by Santana-Romo, Fabián, Lagos, Carlos F, Duarte, Yorley, Castillo, Francisco, Moglie, Yanina, Maestro, Miguel A, Charbe, Nitin, Zacconi, Flavia C

“…The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is…”
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Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies by Mariño-Ocampo, Nory, Rodríguez, Diego F, Guerra Díaz, Daniel, Zúñiga-Núñez, Daniel, Duarte, Yorley, Fuentealba, Denis, Zacconi, Flavia C

“…Direct FXa inhibitors are an important class of bioactive molecules (rivaroxaban, apixaban, edoxaban, and betrixaban) applied for thromboprophylaxis in diverse…”
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PCSK9 conjugated liposomes for targeted delivery of paclitaxel to the cancer cell: A proof-of-concept study by Charbe, Nitin Bharat, Lagos, Carlos F., Ortiz, Cristian Andrés Vilos, Tambuwala, Murtaza, Palakurthi, Sushesh Srivatsa, Zacconi, Flavia C.

“…Ligand-based targeting of the receptors that are overexpressed explicitly on cancer cells represents an effective drug delivery approach to enhance the…”
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Discovery of New Phenylacetone Monooxygenase Variants for the Development of Substituted Indigoids through Biocatalysis by Núñez-Navarro, Nicolás, Salazar Muñoz, Javier, Castillo, Francisco, Ramírez-Sarmiento, César A., Poblete-Castro, Ignacio, Zacconi, Flavia C., Parra, Loreto P.

“…Indigoids are natural pigments obtained from plants by ancient cultures. Romans used them mainly as dyes, whereas Asian cultures applied these compounds as…”
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Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities by Lee, Li-Yen, Hew, Geena Suet Yin, Mehta, Meenu, Shukla, Shakti D., Satija, Saurabh, Khurana, Navneet, Anand, Krishnan, Dureja, Harish, Singh, Sachin Kumar, Mishra, Vijay, Singh, Pankaj Kumar, Gulati, Monica, Prasher, Parteek, Aljabali, Alaa A.A., Tambuwala, Murtaza M., Thangavelu, Lakshmi, Panneerselvam, Jithendra, Gupta, Gaurav, Zacconi, Flavia C., Shastri, Madhur, Jha, Niraj Kumar, Xenaki, Dikaia, MacLoughlin, Ronan, Oliver, Brian G., Chellappan, Dinesh Kumar, Dua, Kamal

“…Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses…”
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Co-synthesis of medium-chain-length polyhydroxyalkanoates and CdS quantum dots nanoparticles in Pseudomonas putida KT2440 by Oliva-Arancibia, Barbara, Órdenes-Aenishanslins, Nicolás, Bruna, Nicolas, Ibarra, Paula S., Zacconi, Flavia C., Pérez-Donoso, José M., Poblete-Castro, Ignacio

“…•In this work, we used KT2440 to efficiently coproduce CdS Qdots and mcl-PHAs in batch cultures.•The PHA and biomass yields in KT2440 were almost not affected…”
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Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression by Satija, Saurabh, Kaur, Harpreet, Tambuwala, Murtaza M, Sharma, Prabal, Vyas, Manish, Khurana, Navneet, Sharma, Neha, Bakshi, Hamid A, Charbe, Nitin B, Zacconi, Flavia C, Aljabali, Alaa A, Nammi, Srinivas, Dureja, Harish, Singh, Thakur G, Gupta, Gaurav, Dhanjal, Daljeet S, Dua, Kamal, Chellappan, Dinesh K, Mehta, Meenu

“…Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the…”
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The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions by Salazar, Javier, Carmona, Thais, Zacconi, Flavia C, Venegas-Yazigi, Diego, Cabello-Verrugio, Claudio, Il Choi, Won, Vilos, Cristian

“…Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could…”
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Synthesis, Biological Activities, and X‑ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds by Watarai, Yusuke, Ishizawa, Michiyasu, Ikura, Teikichi, Zacconi, Flavia C. M, Uno, Shigeyuki, Ito, Nobutoshi, Mouriño, Antonio, Tokiwa, Hiroaki, Makishima, Makoto, Yamada, Sachiko

“…Novel 19-norvitamin D analogues (ADYW1–4, 5a–d) in which an adamantyl diyne side chain is attached directly to the 17-position of the D ring are designed and…”
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Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units by Rodríguez, Diego F, Durán-Osorio, Francisca, Duarte, Yorley, Olivares, Pedro, Moglie, Yanina, Dua, Kamal, Zacconi, Flavia C

“…Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of…”
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Perfluorocarbons Therapeutics in Modern Cancer Nanotechnology for Hypoxiainduced Anti-tumor Therapy by Satija, Saurabh, Sharma, Prabal, Kaur, Harpreet, Dhanjal, Daljeet S, Chopra, Reena S, Khurana, Navneet, Vyas, Manish, Sharma, Neha, Tambuwala, Murtaza M, Bakshi, Hamid A, Charbe, Nitin B, Zacconi, Flavia C, Chellappan, Dinesh K, Dua, Kamal, Mehta, Meenu

“…With an estimated failure rate of about 90%, immunotherapies that are intended for the treatment of solid tumors have caused an anomalous rise in the mortality…”
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Targeting Allosteric Site of PCSK9 Enzyme for the Identification of Small Molecule Inhibitors: An In Silico Drug Repurposing Study by Charbe, Nitin Bharat, Zacconi, Flavia C, Kowthavarapu, Venkata Krishna, Gupta, Churni, Palakurthi, Sushesh Srivatsa, Satheeshkumar, Rajendran, Lokwani, Deepak K, Tambuwala, Murtaza M, Palakurthi, Srinath

“…The primary cause of atherosclerotic cardiovascular disease (ASCVD) is elevated levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase…”
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Novel FXa Inhibitor Identification through Integration of Ligand- and Structure-Based Approaches by Lagos, Carlos F, Segovia, Gerardine F, Nuñez-Navarro, Nicolás, Faúndez, Mario A, Zacconi, Flavia C

“…Factor Xa (FXa), a vitamin K-dependent serine protease plays a pivotal role in the coagulation cascade, one of the most interesting targets for the development…”
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Channelling carbon flux through the meta‐cleavage route for improved poly(3‐hydroxyalkanoate) production from benzoate and lignin‐based aromatics in Pseudomonas putida H by Borrero‐de Acuña, José Manuel, Gutierrez‐Urrutia, Izabook, Hidalgo‐Dumont, Cristian, Aravena‐Carrasco, Carla, Orellana‐Saez, Matias, Palominos‐Gonzalez, Nestor, Duuren, Jozef B. J. H., Wagner, Viktoria, Gläser, Lars, Becker, Judith, Kohlstedt, Michael, Zacconi, Flavia C., Wittmann, Christoph, Poblete‐Castro, Ignacio

“…Engineered P. putida H sets a benchmark in lignin‐based PHA. Balancing the catechol degrading pathways enables improved PHA production. A DO‐stat fed‐batch…”
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Emergence of Three Dimensional Printed Cardiac Tissue: Opportunities and Challenges in Cardiovascular Diseases by Charbe, Nitin B, Zacconi, Flavia C, Amnerkar, Nikhil, Pardhi, Dinesh, Shukla, Priyank, Mukattash, Tareq L, McCarron, Paul A, Tambuwala, Murtaza M

“…Three-dimensional (3D) printing, also known as additive manufacturing, was developed originally for engineering applications. Since its early advancements,…”
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Efficient indium-mediated dehalogenation of aromatics in ionic liquid media by Cañete, Alvaro F, Salas, Cristian O, Zacconi, Flavia C

“…An efficient indium-mediated dehalogenation reaction of haloaromatics and haloheteroaromatics in ionic liquids has been studied. This method is simple and…”
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A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers by Charbe, Nitin B., Castillo, Francisco, Tambuwala, Murtaza M., Prasher, Parteek, Chellappan, Dinesh Kumar, Carreño, Aurora, Satija, Saurabh, Singh, Sachin Kumar, Gulati, Monica, Dua, Kamal, González-Aramundiz, José Vicente, Zacconi, Flavia C.

“…Blood transfusion is the key to life in case of traumatic emergencies, surgeries and in several pathological conditions. An important goal of whole blood or…”
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