Search Results - "Zaccolo, M"

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes by Sin, Y.Y, Edwards, H.V, Li, X, Day, J.P, Christian, F, Dunlop, A.J, Adams, D.R, Zaccolo, M, Houslay, M.D, Baillie, G.S

“…Abstract The small heat shock protein HSP20 is known to be cardioprotective during times of stress and the mechanism underlying its protective abilities…”
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WS06.1 Stabilization of CFTR at the membrane by EPAC1 activation occurs through interaction with NHERF-1 by Lobo, M, Fernandes, J, Amaral, M, Zaccolo, M, Farinha, C.M

“…Background CFTR-mediated ion transport is stimulated by increase in subcortical cAMP levels through protein kinase A (PKA) activation thus triggering CFTR…”
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Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling by Zaccolo, M, Di Benedetto, G, Lissandron, V, Mancuso, L, Terrin, A, Zamparo, I

“…It is becoming increasingly evident that the freely diffusible second messenger cAMP can transduce specific responses by localized signalling. The machinery…”
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A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes by Mongillo, M, Zaccolo, M

“…beta-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation…”
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FRET biosensor to uncover cAMP nano-domains by Zaccolo, M.

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A toolkit for real-time detection of cAMP: insights into compartmentalized signaling by Berrera, M, Dodoni, G, Monterisi, S, Pertegato, V, Zamparo, I, Zaccolo, M

“…The study of cAMP signaling has received a renewed impulse since the recognition that a key aspect of this pathway is the tight spatial control of signal…”
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Imaging the cAMP-dependent signal transduction pathway by Zaccolo, M, Cesetti, T, Di Benedetto, G, Mongillo, M, Lissandron, V, Terrin, A, Zamparo, I

“…In recent years, the development of new technologies based on the green fluorescent protein and FRET (fluorescence resonance energy transfer) has introduced a…”
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Space and time-resolved gene expression experiments on cultured mammalian cells by a single-cell electroporation microarray by Vassanelli, S, Bandiera, L, Borgo, M, Cellere, G, Santoni, L, Bersani, C, Salamon, M, Zaccolo, M, Lorenzelli, L, Girardi, S, Maschietto, M, Dal Maschio, M, Paccagnella, A

“…Single-cell experiments represent the next frontier for biochemical and gene expression research. Although bulk-scale methods averaging populations of cells…”
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Effects of the restrictive cardiomyopathy-associated cardiac troponin I K178E mutation on cAMP signalling at the myofilament by Gee Olmedilla, M, Chao, Y C, Zaccolo, M

“…Abstract Background Catecholaminergic stimulation of cardiac β-adrenergic receptors (β-ARs) and subsequent cAMP signalling control cardiac inotropy and…”
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Modelling and in silico simulation of human induced pluripotent stem cell derived cardiomyocyte electro-mechanical properties by Folkmanaite, M, Zhou, X, Margara, F, Zaccolo, M, Rodriguez, B

“…Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): BHF Background Human induced pluripotent stem cell-derived…”
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Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation by Funaro, A, Spagnoli, GC, Ausiello, CM, Alessio, M, Roggero, S, Delia, D, Zaccolo, M, Malavasi, F

“…We report clear evidence that the interaction of the CD38 molecule with the specific mAb A10 on normal human cells and lines modulates the expression of…”
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Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes by Zaccolo, Manuela, Pozzan, Tullio

“…The second messenger cyclic adenosine monophosphate (cAMP) is the most important modulator of sympathetic control over cardiac contractility. In cardiac…”
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Ezrin and cAMP/PKA have different compartmentalization in CFBE410- and 16HBE14o- cells by Monterisi, S, Favia, M, Guerra, L, Fanelli, T, Reshkin, S.J, Zaccolo, M, Conese, M, Casavola, V

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Elevated propionate signalling drives Pde9a overexpression and contractile dysfunction through increased histone acetylation and propionylation by Park, KC, Crump, NT, Hulikova, A, Ford, KL, Louwman, N, Carnicer, R, Hauton, D, Koschinski, A, Mccullagh, J, Zaccolo, M, Krywawych, S, Milne, TA, Swietach, P

“…Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): British Heart Foundation and Propionic…”
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2161Redox-mediated PKA-RIalpha localisation to the lysosome inhibits myocardial calcium release and robustly reduces myocardial injury by Simon, J N, Vrellaku, B, Monterisi, S, Chu, S, Rawlings, N, Lomas, O, Marchal, G A, Waithe, D, Gajendragadkar, P, Jayaram, R, Channon, K, Swietach, P, Zaccolo, M, Eaton, P, Casadei, B

“…Abstract Background Kinase oxidation is a critical signalling mechanism through which changes in the intracellular redox state alter cardiac function. In the…”
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PKA’s favorite son: prioritizing phosphorylation of phospholamban over cardiac troponin I contributes to diastolic dysfunction in hypertrophic cardiomyopathy by Najafi, A., Schuldt, M., Pham, T.V., Michels, M., Schlossarek, S., Carrier, L., Jimenez, C., Zaccolo, M., van der Velden, J., Kuster, D.W.D.

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Use of Chimeric Fluorescent Proteins and Fluorescence Resonance Energy Transfer to Monitor Cellular Responses by Zaccolo, Manuela, O’Rourke, Brian

“…ABSTRACT—In recent years, the development of new technologies based on the green fluorescent protein and fluorescence resonance energy transfer has introduced…”
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Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator by Ponsioen, Bas, Zhao, Jun, Riedl, Jurgen, Zwartkruis, Fried, van der Krogt, Gerard, Zaccolo, Manuela, Moolenaar, Wouter H, Bos, Johannes L, Jalink, Kees

“…Epac1 is a guanine nucleotide exchange factor for Rap1 that is activated by direct binding of cAMP. In vitro studies suggest that cAMP relieves the interaction…”
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Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway by Mongillo, Marco, Tocchetti, Carlo G, Terrin, Anna, Lissandron, Valentina, Cheung, York-Fong, Dostmann, Wolfgang R, Pozzan, Tullio, Kass, David A, Paolocci, Nazareno, Houslay, Miles D, Zaccolo, Manuela

“…β-Adrenergic signaling via cAMP generation and PKA activation mediates the positive inotropic effect of catecholamines on heart cells. Given the large…”
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Mutations in the Insulin‐Like Factor 3 Receptor Are Associated With Osteoporosis by Ferlin, Alberto, Pepe, Anastasia, Gianesello, Lisa, Garolla, Andrea, Feng, Shu, Giannini, Sandro, Zaccolo, Manuela, Facciolli, Arianna, Morello, Roy, Agoulnik, Alexander I, Foresta, Carlo

“…Introduction: Insulin‐like factor 3 (INSL3) is produced primarily by testicular Leydig cells. It acts by binding to its specific G protein–coupled receptor…”
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