Search Results - "Zacchi, Lucia F."

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins by Medus, Máximo Lopez, Gomez, Gabriela E., Zacchi, Lucía F., Couto, Paula M., Labriola, Carlos A., Labanda, María S., Bielsa, Rodrigo Corti, Clérico, Eugenia M., Schulz, Benjamin L., Caramelo, Julio J.

“…Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N -glycosylated in the lumen of the endoplasmic…”
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Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies by Panagides, Nadya, Zacchi, Lucia F., De Souza, Mitchell J., Morales, Rodrigo A. V., Karnowski, Alexander, Liddament, Mark T., Owczarek, Catherine M., Mahler, Stephen M., Panousis, Con, Jones, Martina L., Fercher, Christian

“…Monoclonal antibodies (mAbs) are one of the most successful and versatile protein-based pharmaceutical products used to treat multiple pathological conditions…”
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Mds3 Regulates Morphogenesis in Candida albicans through the TOR Pathway by Zacchi, Lucia F., Gomez-Raja, Jonatan, Davis, Dana A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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HOS2 and HDA1 encode histone deacetylases with opposing roles in Candida albicans morphogenesis by Zacchi, Lucia F, Schulz, Wade L, Davis, Dana A

“…Epigenetic mechanisms regulate the expression of virulence traits in diverse pathogens, including protozoan and fungi. In the human fungal pathogen Candida…”
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Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product by Zacchi, Lucia F., Roche-Recinos, Dinora, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L., Howard, Christopher B.

“…Coagulation factor IX (FIX) is a complex post-translationally modified human serum glycoprotein and high-value biopharmaceutical. The quality of recombinant…”
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SWATH-MS Glycoproteomics Reveals Consequences of Defects in the Glycosylation Machinery by Zacchi, Lucia F., Schulz, Benjamin L.

“…Glycan macro- and microheterogeneity have profound impacts on protein folding and function. This heterogeneity can be regulated by physiological or…”
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Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1–directed novel therapeutics by Pickett, Jessica R, Wu, Yuao, Zacchi, Lucia F, Ta, Hang T

“…Abstract Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical contributor to atherosclerosis and consequently as an attractive…”
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N-glycoprotein macroheterogeneity: biological implications and proteomic characterization by Zacchi, Lucia F., Schulz, Benjamin L.

“…Glycosylation is a co- and post-translational modification that is critical for the regulation of the biophysical properties and biological activities of…”
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Low dosage of histone H4 leads to growth defects and morphological changes in Candida albicans by Zacchi, Lucia F, Selmecki, Anna M, Berman, Judith, Davis, Dana A

“…Chromatin function depends on adequate histone stoichiometry. Alterations in histone dosage affect transcription and chromosome segregation, leading to growth…”
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Intracellular complexes of the early-onset torsion dystonia-associated AAA+ ATPase TorsinA by Li, Hui, Wu, Hui-Chuan, Liu, Zhonghua, Zacchi, Lucia F, Brodsky, Jeffrey L, Zolkiewski, Michal

“…A single GAG codon deletion in the gene encoding torsinA is linked to most cases of early-onset torsion dystonia. TorsinA is an ER-localized…”
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Shuttle vectors for facile gap repair cloning and integration into a neutral locus in Candida albicans by Gerami-Nejad, Maryam, Zacchi, Lucia F, McClellan, Mark, Matter, Kathleen, Berman, Judith

“…Candida albicans is the most prevalent fungal pathogen of humans. The current techniques used to construct C. albicans strains require integration of exogenous…”
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Data-Independent Acquisition for Yeast Glycoproteomics by Zacchi, Lucía F, Schulz, Benjamin L

“…Glycosylation is a complex posttranslational modification that is critical for regulating the functions of diverse proteins. Analysis of protein glycosylation…”
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S‑Trap Eliminates Cell Culture Media Polymeric Surfactants for Effective Proteomic Analysis of Mammalian Cell Bioreactor Supernatants by Zacchi, Lucia F, Recinos, Dinora Roche, Otte, Ellen, Aitken, Campbell, Hunt, Tony, Sandford, Vanessa, Lee, Yih Yean, Schulz, Benjamin L, Howard, Christopher B

“…Proteomic analysis of bioreactor supernatants can inform on cellular metabolic status, viability, and productivity, as well as product quality, which can in…”
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The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy by McCulloch, Timothy R, Rossi, Gustavo R, Miranda-Hernandez, Socorro, Valencia-Hernandez, Ana Maria, Alim, Louisa, Belle, Clemence J, Krause, Andrew, Zacchi, Lucia F, Lam, Pui Yeng, Nakamura, Kyohei, Kupz, Andreas, Wells, Timothy J, Souza-Fonseca-Guimaraes, Fernando

“…Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of…”
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Identification of novel glycosylation events on human serum-derived factor IX by Pegg, Cassandra L., Zacchi, Lucia F., Recinos, Dinora Roche, Howard, Christopher B., Schulz, Benjamin L.

“…Human Factor IX is a highly post-translationally modified protein that is an important clotting factor in the blood coagulation cascade. Functional…”
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N-glycosylation on Oryza sativa root germin-like protein 1 is conserved but not required for stability or activity by Rubbab, Tehseen, Pegg, Cassandra L., Phung, Toan K., Nouwens, Amanda S., Yeo, K.Y. Benjamin, Zacchi, Lucia F., Muhammad, Amna, Naqvi, S.M. Saqlan, Schulz, Benjamin L.

“…Germin and germin-like proteins (GLPs) are a broad family of extracellular glycoproteins ubiquitously distributed in plants. Overexpression of Oryza sativa…”
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The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence by Jenull, Sabrina, Mair, Theresia, Tscherner, Michael, Penninger, Philipp, Zwolanek, Florian, Silao, Fitz-Gerald S., de San Vicente, Kontxi Martinez, Riedelberger, Michael, Bandari, Naga C., Shivarathri, Raju, Petryshyn, Andriy, Chauhan, Neeraj, Zacchi, Lucia F., -Landmann, Salomé LeibundGut, Ljungdahl, Per O., Kuchler, Karl

“…Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation…”
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Glycoproteomic measurement of site-specific polysialylation by Pelingon, Ruby, Pegg, Cassandra L., Zacchi, Lucia F., Phung, Toan K., Howard, Christopher B., Xu, Ping, Hardy, Matthew P., Owczarek, Catherine M., Schulz, Benjamin L.

“…Polysialylation is the enzymatic addition of a highly negatively charged sialic acid polymer to the non-reducing termini of glycans. Polysialylation plays an…”
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Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis by Fercher, Christian, Zacchi, Lucía F.

“…TorsinA is a AAA+ ATPase involved in the severe neurological disease Early Onset Torsion Dystonia. Despite the impressive progress in the field in the recent…”
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DIALib: an automated ion library generator for data independent acquisition mass spectrometry analysis of peptides and glycopeptides by Phung, Toan K, Zacchi, Lucia F, Schulz, Benjamin L

“…Data Independent Acquisition (DIA) Mass Spectrometry (MS) workflows allow unbiased measurement of all detectable peptides from complex proteomes, but require…”
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