Search Results - "Zacchei, A G"

Disposition of radiolabeled imipenem and cilastatin in normal human volunteers by NORRBY, S. R, ROGERS, J. D, FERBER, F, JONES, K. H, ZACCHEI, A. G, WEIDNER, L. L, DEMETRIADES, L, GRAVALLESE, D. A, HSIEH, J. Y.-K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Gender differences in toxicokinetics, liver metabolism, and plasma esterase activity: observations from a chronic (27-week) toxicity study of enalapril/diltiazem combinations in rats by Los, L E, Welsh, D A, Herold, E G, Bagdon, W J, Zacchei, A G

“…Diltiazem (DTZ), a calcium channel blocker, and enalapril (EN), an angiotensin-converting enzyme inhibitor, are being developed as combination therapy for…”
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Disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine in rats, dogs, and monkeys by Hucker, H B, Hutt, J E, White, S D, Arison, B H, Zacchei, A G

“…The disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a new agent with potent anticonvulsant, central…”
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Enantioselective induction of peroxisomal proliferation in CD-1 mice by leukotriene antagonists by Grossman, S J, DeLuca, J G, Zamboni, R J, Keenan, K P, Patrick, D H, Herold, E G, van Zwieten, M J, Zacchei, A G

“…The effects of a racemic leukotriene antagonist (MK-0571) and its component enantiomers (L-668,018 and L-668,019) on hepatic peroxisome proliferation were…”
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Physiological disposition and metabolism of 5-(2',4'-difluorophenyl)salicyclic acid, a new salicylate by Tocco, D J, Breault, G O, Zacchei, A G, Steelman, S L, Perrier, C V

“…5-(2'4'-Difluorophenyl) [carboxy-14C]salicyclic acid (MK-647) was quickly and completely absorbed in rats, dogs, and man. Peak levels of plasma radioactivity…”
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Stereospecific HPLC method for the quantitation of the enantiomers of MK-0571, a potent leukotriene D4 receptor antagonist, in biological specimens by Lee, L L, Zacchei, A G

“…A stereospecific HPLC bioanalytical method was developed for quantitation of the enantiomers of MK-0571, a leukotriene D4 receptor antagonist. The procedure…”
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Thiobenzamide-induced hepatotoxicity: effects of substituents and route of administration on the nature and extent of liver injury by Grossman, S J, Patrick, D H, Kornbrust, D, Smith, P F, Herold, E G, DeLuca, J G, Zacchei, A G

“…Differences in the nature and extent of hepatic injury were examined after administration of para-substituted thiobenzamides to rats. In accordance with…”
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Stereoselectivity in the disposition and metabolism of the uricosuric-diuretic agent, indacrinone, in Rhesus monkeys by Zacchei, A G, Dobrinska, M R, Wishousky, T I, Kwan, K C, White, S D

“…The physiological disposition following intravenous dosing of the separate enantiomers of indacrinone-14C (I), and of their major metabolite,…”
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The physiological disposition of the uricosuric-saluretic agent (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic acid (MK-196) in the rat, dog, and monkey by Zacchei, A G, Wishousky, T I

“…The physiological disposition of a new saluretic-uricosuric agent, (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic acid (MK-196), was studied in the…”
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Physiologic disposition and metabolism of an anti-ulcer agent, N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea, in rats, dogs, and monkeys by Hucker, H B, Stauffer, S C, White, S D, Arison, B H, Zacchei, A G

“…14C-N-(2-Diisopropylaminoethyl)-N-(4,6-dimethyl-2-dimethyl- 2-pyridyl)-N',N'-dimethylurea (I) was administered orally to dogs and rats and to rhesus, African…”
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The metabolic disposition of (S)-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in rats, dogs, and humans by Vickers, S, Duncan, C A, Arison, B H, Davies, R O, Ferguson, R, Zacchei, A G

“…Studies of the metabolic disposition of (S)-2-(3-tert-butylamino-2-hydroxypropoxy)-3-[14C]cyanopyridine (I) have been performed in humans, dogs, and…”
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Urinary metabolites of amitriptyline in the dog by Hucker, H B, Balletto, A J, Demetriades, J, Arison, B H, Zacchei, A G

“…Dogs excreted approximately 45% of an oral dose of 14C-amitriptyline (30 mg/kg) in the urine in 24 hr. Two new urinary metabolites of the drug were identified…”
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Toxicokinetic analysis of losartan during gestation and lactation in the rat by Spence, S. G., Zacchei, A. G., Lee, L. L., Baldwin, C. L., Berna, R. A., Mattson, B. A., Eydelloth, R. S.

“…Previous developmental and reproductive toxicity studies in rats with losartan, a potent AT1‐selective angiotensin II (AII) receptor antagonist, correlated…”
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The biotransformation of (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee by Zacchei, A G, Wishousky, T I, Arison, B H, Fanelli, Jr, G M

“…The metabolism of a novel polyvalent saluretic agent (6,7-dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxy)acetic acid (MK-196) was studied in the chimpanzee…”
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Gas chromatographic determination of a diuretic-antihypertensive agent, (+/-)-[[6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl] oxy]acetic acid, in biological fluids by Weidner, L L, Zacchei, A G

“…A method for the measurement of a potential diuretic-antihypertensive agent, (+/-)-[[6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl] oxy]acetic acid,…”
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The metabolism of (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid in chimpanzee and man by Zacchei, A G, Wishousky, T I, Arison, B H, Hitzenberger, G

“…The metabolism of the polyvalent saluretic agent (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid was studied in chimpanzee and man. The…”
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Physiological disposition and metabolic fate of a new antiarrhythmic agent, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine in the rat, dog, monkey, baboon, and man by Zacchei, A G, Weidner, L L, Besselaar, G H, Raftery, E B

“…The physiological disposition of a new orally active antiarrhythmic drug, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl)benzylamine…”
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Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man by Hucker, H B, Stauffer, S C, Balletto, A J, White, S D, Zacchei, A G, Arison, B H

“…The absorption, distribution, excretion, and metabolism of 3-(5 H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine (cyclobenzaprine) were…”
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Epoxide metabolites of protriptyline in rat urine by Hucker, H B, Balletto, A J, Demetriades, J, Arison, B H, Zacchei, A G

“…Two epoxide metabolites of 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene (protriptyline) were identified in the urine of rats given 14-C-labeled drug…”
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An electron-capture gas chromatographic method for the determination of piperidine content in brain tissue by Zacchei, A G, Weidner, L L

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