Search Results - "Zaccardi, Margot J."

Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-glycerol phosphate synthase enzymes at their adaptive temperatures by Zaccardi, Margot J., Mannweiler, Olga, Boehr, David D.

“…► Catalytic mechanisms of thermophilic–mesophilic enzymes may differ. ► Product release is rate-determining for thermophilic IGPS at low temperatures. ► But at…”
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Functional Identification of the General Acid and Base in the Dehydration Step of Indole-3-glycerol Phosphate Synthase Catalysis by Zaccardi, Margot J., Yezdimer, Eric M., Boehr, David D.

“…The tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase is a proposed target for new antimicrobials and is a favored starting framework in…”
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Loop‐loop interactions govern multiple steps in indole‐3‐glycerol phosphate synthase catalysis by Zaccardi, Margot J., O'Rourke, Kathleen F., Yezdimer, Eric M., Loggia, Laura J., Woldt, Svenja, Boehr, David D.

“…Substrate binding, product release, and likely chemical catalysis in the tryptophan biosynthetic enzyme indole‐3‐glycerol phosphate synthase (IGPS) are…”
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Preparation of Chemically Etched Tips for Ambient Instructional Scanning Tunneling Microscopy by Zaccardi, Margot J, Winkelmann, Kurt, Olson, Joel A

“…A first-year laboratory experiment that utilizes concepts of electrochemical tip etching for scanning tunneling microscopy (STM) is described. This experiment…”
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Mechanistic analysis of the tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase by Zaccardi, Margot J

“…The design and production of enzymes that are capable of performing reactions in an industrial setting is of profound importance for the advancement of…”
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