Search Results - "Zabrocki, J."

Comparison of insect kinin analogs with cis-peptide bond, type VI-turn motifs identifies optimal stereochemistry for interaction with a recombinant arthropod kinin receptor from the southern cattle tick Boophilus microplus by Taneja-Bageshwar, S., Strey, A., Kaczmarek, K., Zabrocki, J., Pietrantonio, P.V., Nachman, R.J.

“…The multifunctional ‘insect kinins’ share the evolutionarily conserved C-terminal pentapeptide motif Phe-X 1-X 2-Trp-Gly-NH 2, where X 1 = His, Asn, Ser, or…”
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Tetrazole analogues of cyclolinopeptide A: Synthesis, conformation, and biology by Kaczmarek, Krzysztof, Jankowski, Stefan, Siemion, Ignacy Z., Wieczorek, Zbigniew, Benedetti, Ettore, Di Lello, Paola, Isernia, Carla, Saviano, Michele, Zabrocki, Janusz

“…Linear and cyclic analogues of cyclolinopeptide A (CLA) with two dipeptide segments (Val5Pro6 and Pro6Pro7) replaced by their tetrazole derivatives were…”
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Correlating biological activity with calculated geometric motifs in cyclolinopeptide A analogs by Zubrzak, P., Leplawy, M. T., Kowalski, M. L., Szkudlińska, B., Paneth, P., Silberring, J., Suder, P., Zabrocki, J.

“…Three linear and three cyclic analogs of cyclolinopeptide A, with phenylalanine residues in position 8 and/or 9 replaced by N‐benzylglycine, were synthesized…”
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Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids by MARSHALL, G. R, HODGKIN, E. E, LANGS, D. A, SMITH, G. D, ZABROCKI, J, LEPLAWY, M. T

“…The presence of multiple alpha,alpha-dialkyl amino acids such as alpha-methylalanine (alpha-aminoisobutyric acid, Aib) leads to predominantly helical…”
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A new class of peptide chelating agents towards copper(II) ions by Lodyga-Chruscinska, E, Micera, G, Sanna, D, Olczak, J, Zabrocki, J

“…Potentiometric and spectroscopic data including CD and EPR results as well as theoretical calculations have shown that the insertion of the tetrazole ring…”
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Analogues of arginine vasopressin and its agonist and antagonist modified in the N-terminal part of the molecule with l-β-homophenylalanine by Sobolewski, D., Kowalczyk, W., Prahl, A., Derdowska, I., Slaninová, J., Zabrocki, J., Lammek, B.

“…:  In continuation of our efforts to elucidate the role of positions 2 and 3 in arginine vasopressin (AVP) and its analogues, we designed and synthesized…”
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Potent bradykinin antagonists containing N-benzylglycine or N-benzyl-l-alanine in position 8 by Dawidowska, O., Wierzba, T.H., Prahl, A., Kowalczyk, W., Derdowska, I., Neubert, K., Zabrocki, J., Olejniczak, B., Juzwa, W., Lammek, B.

“…:  Two new analogues of a previously designed bradykinin (BK) antagonist, d‐Arg‐Arg‐Pro‐Hyp‐Gly‐Thi‐Ser‐d‐Phe‐Thi‐Arg, substituted in position 8 by…”
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Solution conformational study of Scyliorhinin I analogues with conformational constraints by two-dimensional NMR and theoretical conformational analysis by Rodziewicz-Motowidło, S., Łegowska, A., Qi, X.-F., Czaplewski, C., Liwo, A., Rolka, K., Sowiński, P., Mozga, W., Olczak, J., Zabrocki, J.

“…Two analogues of Scyliorhinin I (ScyI), a tachykinin with N‐MeLeu in position 8 and a 1,5‐disubstituted tetrazole ring between positions 7 and 8, introduced in…”
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A thyrotropin-releasing hormone analogue: pGlu-Phe-D-Pro-psi [CN4]-NMe at 293 and 107 K by Howell, P L, Pangborn, W A, Marshall, G R, Zabrocki, J, Smith, G D

“…Data have been measured at two temperatures, 293 K and 107 K, for a crystal of a thyrotropin-releasing hormone analogue, pGlu-Phe-D-Pro-psi [CN4]-NMe,…”
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β-Amino Acid Analogs of an Insect Neuropeptide Feature Potent Bioactivity and Resistance to Peptidase Hydrolysis by Zubrzak, P, Williams, H, Coast, G.M, Isaac, R.E, Reyes-Rangel, G, Juaristi, E, Zabrocki, J, Nachman, R.J

“…Insect neuropeptides of the insect kinin class share a common C-terminal pentapeptide sequence F1X1²X2³W4G5-NH2 (X2³ = P, S, A) and regulate such critical…”
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Active Insect Kinin Analog with 4-Aminopyroglutamate, A Novel cis-Peptide Bond, Type VI β-Turn Motif by Nachman, Ronald J, Kaczmarek, Krzysztof, Williams, Howard J, Coast, Geoffrey M, Zabrocki, Janusz

“…The insect kinins are potent diuretic peptides that preferentially form a cis-Pro, type VI β-turn. An insect kinin analog containing…”
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Coordination ability of insect kinin analogs by Łodyga-Chruścińska, E., Ołdziej, S., Sanna, D., Micera, G., Chruściński, L., Kaczmarek, K., Nachman, R.J., Zabrocki, J., Sykuła, A.

“…Spectroscopic data, including electronic absorption, CD and EPR results, as well as theoretical calculations have shown that the insertion of…”
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Comparison of Insect Kinin Analogs With cis-Peptide Bond Motif 4-Aminopyroglutamate Identifies Optimal Stereochemistry for Diuretic Activity by Kaczmarek, K, Williams, H.J, Coast, G.M, Scott, A.I, Zabrocki, J, Nachman, R.J

“…The insect kinins are present in a wide variety of insects and function as potent diuretic peptides, though they are subject to rapid degradation by internal…”
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Analogues of Neurohypophyseal Hormones, Oxytocin and Arginine Vasopressin, Conformationally Restricted in the N-Terminal Part of the Molecule by Kowalczyk, Wioleta, Prahl, Adam, Derdowska, Izabela, Sobolewski, Dariusz, Olejnik, Jadwiga, Zabrocki, Janusz, Borovicková, Lenka, Slaninová, Jiřina, Lammek, Bernard

“…It is generally accepted that the conformation of the N-terminal part of neurohypophyseal hormones analogues is important for their pharmacological activity…”
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cis-peptide bond mimetic tetrazole analogs of the insect kinins identify the active conformation by Nachman, Ronald J, Zabrocki, Janusz, Olczak, Jacek, Williams, Howard J, Moyna, Guillermo, Ian Scott, A, Coast, Geoffrey M

“…The insect kinin neuropeptides have been implicated in the regulation of water balance, digestive organ contraction, and energy mobilization in a number of…”
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First Rigid Peptide Foldamers with an Alternating Cis−Trans Amide Sequence. An Oligomeric Building Block for the Construction of New Helices, Large-Ring Cyclic Correlates, and Nanotubes by Crisma, Marco, Moretto, Alessandro, Toniolo, Claudio, Kaczmarek, Krzysztof, Zabrocki, Janusz

“…As part of a program evaluating homochiral and heterochiral amino- and carboxylic acid-substituted γ-lactams as conformationally constrained dipeptide building…”
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Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO sub(3)H) in sulfakinins for myotropic and food intake-inhibition activity in insects by Nachman, R J, Vercammen, T, Williams, H, Kaczmarek, K, Zabrocki, J, Schoofs, L

“…The aliphatic amino diacid alpha -aminosuberic acid can function as an effective, stable mimic of the hydrolysis-susceptible Tyr(SO sub(3)H) group in…”
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Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO 3H) in sulfakinins for myotropic and food intake-inhibition activity in insects by Nachman, Ronald J., Vercammen, Tom, Williams, Howard, Kaczmarek, Krzysztof, Zabrocki, Janusz, Schoofs, Liliane

“…The aliphatic amino diacid α-aminosuberic acid can function as an effective, stable mimic of the hydrolysis-susceptible Tyr(SO 3H) group in sulfakinin…”
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Chelating ability of proctolin tetrazole analogue by Łodyga-Chruścińska, Elżbieta, Sanna, Daniele, Micera, Giovanni, Chruściński, Longin, Olejnik, Jadwiga, Nachman, Ronald J, Zabrocki, Janusz

“…The aim of the investigation was to establish the chelating ability of a new proctolin analogue of the sequence Arg-Tyr-LeuΨ[CN4]Ala-Thr towards copper(II)…”
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A C-terminal aldehyde insect kinin analog enhances inhibition of weight gain and induces significant mortality in Helicoverpa zea larvae by Nachman, Ronald J., Coast, Geoffrey M., Douat, Céline, Fehrentz, Jean-Alain, Kaczmarek, Krzyztoff, Zabrocki, Janusz, Pryor, Nan W., Martinez, Jean

“…The first reported examples of C-terminal aldehyde analogs of an insect neuropeptide are described. They are hexapeptide insect kinin analogs Boc-VFFPWG-H and…”
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