Search Results - "Zablotsky, Kaitlin"
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789 Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer
Published in Journal for immunotherapy of cancer (01-11-2020)“…BackgroundTriple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Immune checkpoint inhibitors (ICI) have entered the…”
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Intratumoral Plasmid IL12 Expands CD8 + T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy
Published in Clinical cancer research (01-05-2021)“…Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1…”
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Abstract CT022: Intratumoral plasmid IL-12 and electroporation in pre-treated inoperable locally advanced or recurrent triple-negative breast cancer (TNBC)
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Introduction: TNBC accounts for ~15% of breast cancer and is associated with an increased risk of relapse. Emerging data suggest that some TNBC…”
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Abstract PS17-22: Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patients
Published in Cancer research (Chicago, Ill.) (15-02-2021)“…Abstract Interleukin-12 (IL-12) is a pro-inflammatory cytokine involved in the generation of an inflammatory tumor microenvironment and is critical in…”
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