Search Results - "Zabierek, Anna A."

Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera by Kraus, Manfred, Wang, Yuxun, Aleksandrowicz, Dan, Bachman, Eric, Szewczak, Alexander A, Walker, Deborah, Xu, Lin, Bouthillette, Melaney, Childers, Kaleen M, Dolinski, Brian, Haidle, Andrew M, Kopinja, Johnny, Lee, Linda, Lim, Jongwon, Little, Kevin D, Ma, Yanhong, Mathur, Anjili, Mo, Jan-Rung, O'Hare, Erin, Otte, Ryan D, Taoka, Brandon M, Wang, Wenxian, Yin, Hong, Zabierek, Anna A, Zhang, Weisheng, Zhao, Shuxia, Zhu, Joe, Young, Jonathan R, Marshall, C Gary

“…A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2)…”
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Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors by Katz, Jason D., Haidle, Andrew, Childers, Kaleen K., Zabierek, Anna A., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Su, Hua-Poo, Munshi, Sanjeev, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan

“…[Display omitted] The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal…”
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MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation by Haidle, Andrew M., Childers, Kaleen K., Zabierek, Anna A., Katz, Jason D., Jewell, James P., Hou, Yongquan, Altman, Michael D., Szewczak, Alexander, Chen, Dapeng, Harsch, Andreas, Hayashi, Mansuo, Warren, Lee, Hutton, Michael, Nuthall, Hugh, Stanton, Matt G., Davies, Ian W., Munoz, Ben, Northrup, Alan

“…[Display omitted] Attempts to optimize pharmacokinetic properties in a promising series of pyrrolopyrimidinone MARK inhibitors for the treatment of Alzheimer’s…”
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Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms by Haidle, Andrew M, Zabierek, Anna A, Childers, Kaleen K, Rosenstein, Craig, Mathur, Anjili, Altman, Michael D, Chan, Grace, Xu, Lin, Bachman, Eric, Mo, Jan-Rung, Bouthillette, Melaney, Rush, Thomas, Tempest, Paul, Marshall, C Gary, Young, Jonathan R

“…A series of carboxamide-substituted thiophenes demonstrating inhibition of JAK2 is described. Development of this chemical series began with the bioisosteric…”
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A practical, two-step synthesis of 1-alkyl-4-aminopyrazoles by Zabierek, Anna A., Konrad, Kaleen M., Haidle, Andrew M.

“…A novel synthesis of N1 alkyl-substituted pyrazoles with a free amino group at the C4 position is described. Commercially available 4-nitropyrazole was found…”
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