Search Results - "Zabielski, Piotr"

Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes by Roszczyc-Owsiejczuk, Kamila, Zabielski, Piotr

“…Insulin resistance is defined as a complex pathological condition of abnormal cellular and metabolic response to insulin. Obesity and consumption of high-fat…”
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Effect of metformin on bioactive lipid metabolism in insulin-resistant muscle by Zabielski, Piotr, Chacinska, Marta, Charkiewicz, Karol, Baranowski, Marcin, Gorski, Jan, Blachnio-Zabielska, Agnieszka U

“…Intramuscular accumulation of bioactive lipids leads to insulin resistance and type 2 diabetes (T2D). There is lack of consensus concerning which of the lipid…”
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Aquaporins in insulin resistance and diabetes: More than channels by Galli, Mauro, Hameed, Ahsan, Żbikowski, Arkadiusz, Zabielski, Piotr

“…Aquaporins (AQPs) are part of the family of the integral membrane proteins. Their function is dedicated to the transport of water, glycerol, ammonia, urea,…”
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Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance by Żbikowski, Arkadiusz, Błachnio-Zabielska, Agnieszka, Galli, Mauro, Zabielski, Piotr

“…Adipose tissue (AT) is an endocrine organ involved in the management of energy metabolism via secretion of adipokines, hormones, and recently described…”
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shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice by Roszczyc-Owsiejczuk, Kamila, Imierska, Monika, Sokołowska, Emilia, Kuźmicki, Mariusz, Pogodzińska, Karolina, Błachnio-Zabielska, Agnieszka, Zabielski, Piotr

“…Prolonged consumption of diet rich in fats is regarded as the major factor leading to the insulin resistance (IR) and type 2 diabetes (T2D). Emerging evidence…”
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The effect of high fat diet and metformin treatment on liver lipids accumulation and their impact on insulin action by Zabielski, Piotr, Hady, Hady Razak, Chacinska, Marta, Roszczyc, Kamila, Gorski, Jan, Blachnio-Zabielska, Agnieszka U.

“…We sought to determine whether metformin treatment reverses a high-fat diet (HFD)-induced hepatic insulin resistance (IRes) and to identify lipid intermediates…”
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Exploring protein relative relations in skeletal muscle proteomic analysis for insights into insulin resistance and type 2 diabetes by Czajkowska, Anna, Czajkowski, Marcin, Szczerbinski, Lukasz, Jurczuk, Krzysztof, Reska, Daniel, Kwedlo, Wojciech, Kretowski, Marek, Zabielski, Piotr, Kretowski, Adam

“…The escalating prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2D) underscores the urgent need for improved early detection techniques and…”
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Silencing the glycerol-3-phosphate acyltransferase-1 gene in the liver of mice fed a high-fat diet, enhances insulin sensitivity and glucose metabolism by promoting fatty acid beta-oxidation by Zabielski, Piotr, Roszczyc-Owsiejczuk, Kamila, Imierska, Monika, Pogodzińska, Karolina, Błachnio-Zabielska, Agnieszka U.

“…Liver plays a central role in systemic glucose and lipid metabolism. High-fat diet (HFD) and obesity are related to hepatic lipid accumulation and insulin…”
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The Crucial Role of C18-Cer in Fat-Induced Skeletal Muscle Insulin Resistance by Blachnio-Zabielska, Agnieszka U., Chacinska, Marta, Vendelbo, Mikkel H., Zabielski, Piotr

“…Background/Aims: Muscle bioactive lipids accumulation leads to several disorder states. The most common are insulin resistance (IR) and type 2 diabetes. There…”
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Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells by Oscilowska, Ilona, Huynh, Thi Y. L., Baszanowska, Weronika, Prokop, Izabela, Surazynski, Arkadiusz, Galli, Mauro, Zabielski, Piotr, Palka, Jerzy

“…Proline oxidase (POX) is mitochondrial proline-degrading enzyme of dual apoptosis/survival function. POX expression and proline availability are considered an…”
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Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern by Toczylowski, Kacper, Hirnle, Tomasz, Harasiuk, Dorota, Zabielski, Piotr, Lewczuk, Anna, Dmitruk, Iwona, Ksiazek, Monika, Sulik, Artur, Gorski, Jan, Chabowski, Adrian, Baranowski, Marcin

“…Adipokines in serum derive mainly from subcutaneous and visceral adipose tissues. Epicardial adipose tissue (EAT), being a relatively small but unique fat…”
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Diverse Sphingolipid Profiles in Rectal and Colon Cancer by Markowski, Adam R, Błachnio-Zabielska, Agnieszka U, Pogodzińska, Karolina, Markowska, Anna J, Zabielski, Piotr

“…Colorectal cancer is a heterogenous group of neoplasms showing a variety of clinical and pathological features depending on their anatomical location…”
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GPAT Gene Silencing in Muscle Reduces Diacylglycerols Content and Improves Insulin Action in Diet-Induced Insulin Resistance by Kojta, Iwona, Zabielski, Piotr, Roszczyc-Owsiejczuk, Kamila, Imierska, Monika, Sokołowska, Emilia, Błachnio-Zabielska, Agnieszka

“…Skeletal muscle is an important tissue responsible for glucose and lipid metabolism. High-fat diet (HFD) consumption is associated with the accumulation of…”
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The Effect of Silencing the Genes Responsible for the Level of Sphingosine-1-phosphate on the Apoptosis of Colon Cancer Cells by Markowski, Adam R, Żbikowski, Arkadiusz, Zabielski, Piotr, Chlabicz, Urszula, Sadowska, Patrycja, Pogodzińska, Karolina, Błachnio-Zabielska, Agnieszka U

“…Sphingosine-1-phosphate (S1P) and ceramides (Cer) are engaged in key events of signal transduction, but their involvement in the pathogenesis of colorectal…”
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Effect of plasma free fatty acid supply on the rate of ceramide synthesis in different muscle types in the rat by Zabielski, Piotr, Błachnio-Zabielska, Agnieszka Urszula, Wójcik, Beata, Chabowski, Adrian, Górski, Jan

“…Ceramide is a key compound in sphingolipid metabolism. Dynamics of ceramide synthesis is important in the several biological processes, such as induction of…”
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The Impact of OMEGA-3 Fatty Acids Supplementation on Insulin Resistance and Content of Adipocytokines and Biologically Active Lipids in Adipose Tissue of High-Fat Diet Fed Rats by Chacińska, Marta, Zabielski, Piotr, Książek, Monika, Szałaj, Przemysław, Jarząbek, Katarzyna, Kojta, Iwona, Chabowski, Adrian, Błachnio-Zabielska, Agnieszka Urszula

“…It has been established that OMEGA-3 polyunsaturated fatty acids (PUFAs) may improve lipid and glucose homeostasis and prevent the "low-grade" state of…”
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Inhibition of Ceramide De Novo Synthesis Affects Adipocytokine Secretion and Improves Systemic and Adipose Tissue Insulin Sensitivity by Blachnio-Zabielska, Agnieszka U, Hady, Hady Razak, Markowski, Adam R, Kurianiuk, Adam, Karwowska, Alicja, Górski, Jan, Zabielski, Piotr

“…Ceramide accumulation in muscle and in liver is implicated in the induction of insulin resistance. Much less in known about the role of ceramide in adipose…”
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Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice by Zabielski, Piotr, Lanza, Ian R, Gopala, Srinivas, Heppelmann, Carrie J Holtz, Bergen, 3rd, H Robert, Dasari, Surendra, Nair, K Sreekumaran

“…Insulin plays pivotal role in cellular fuel metabolism in skeletal muscle. Despite being the primary site of energy metabolism, the underlying mechanism on how…”
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The Role of Acyl-CoA Synthetase 1 in Bioactive Lipid Accumulation and the Development of Hepatic Insulin Resistance by Zabielski, Piotr, Imierska, Monika, Roszczyc-Owsiejczuk, Kamila, Kuźmicki, Mariusz, Rogalski, Paweł, Daniluk, Jarosław, Błachnio-Zabielska, Agnieszka U

“…The liver plays a crucial role in glucose metabolism. Obesity and a diet rich in fats (HFD) contribute to the accumulation of intracellular lipids. The aim of…”
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Sustained decrease in plasma sphingosine-1-phosphate concentration and its accumulation in blood cells in acute myocardial infarction by Knapp, Małgorzata, Lisowska, Anna, Zabielski, Piotr, Musiał, Włodzimierz, Baranowski, Marcin

“…•We measured blood sphingolipid content in patients with myocardial infarction.•Plasma sphingosine-1-phosphate (S1P) concentration was decreased.•S1P…”
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