Search Results - "Zabetian, Cyrus P."

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome by Hill‐Burns, Erin M., Debelius, Justine W., Morton, James T., Wissemann, William T., Lewis, Matthew R., Wallen, Zachary D., Peddada, Shyamal D., Factor, Stewart A., Molho, Eric, Zabetian, Cyrus P., Knight, Rob, Payami, Haydeh

“…ABSTRACT Background There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of gut microbiota could explain several…”
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Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases by Espay, Alberto J, Vizcarra, Joaquin A, Marsili, Luca, Lang, Anthony E, Simon, David K, Merola, Aristide, Josephs, Keith A, Fasano, Alfonso, Morgante, Francesca, Savica, Rodolfo, Greenamyre, J Timothy, Cambi, Franca, Yamasaki, Tritia R, Tanner, Caroline M, Gan-Or, Ziv, Litvan, Irene, Mata, Ignacio F, Zabetian, Cyrus P, Brundin, Patrik, Fernandez, Hubert H, Standaert, David G, Kauffman, Marcelo A, Schwarzschild, Michael A, Sardi, S Pablo, Sherer, Todd, Perry, George, Leverenz, James B

“…The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer…”
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The Genetics of Parkinson Disease by Bekris, Lynn M., Mata, Ignacio F., Zabetian, Cyrus P.

“…Parkinson disease (PD) is the second most common neurodegenerative disorder. In most instances, PD is thought to result from a complex interaction between…”
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Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens by Wallen, Zachary D., Appah, Mary, Dean, Marissa N., Sesler, Cheryl L., Factor, Stewart A., Molho, Eric, Zabetian, Cyrus P., Standaert, David G., Payami, Haydeh

“…In Parkinson’s disease (PD), gastrointestinal features are common and often precede the motor signs. Braak and colleagues proposed that PD may start in the…”
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Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region by Wissemann, William T., Hill-Burns, Erin M., Zabetian, Cyrus P., Factor, Stewart A., Patsopoulos, Nikolaos, Hoglund, Bryan, Holcomb, Cherie, Donahue, Ryan J., Thomson, Glenys, Erlich, Henry, Payami, Haydeh

“…Historically, association of disease with the major histocompatibility complex (HLA) genes has been tested with HLA alleles that encode antigen-binding…”
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Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression by Shi, Min, Bradner, Joshua, Hancock, Aneeka M., Chung, Kathryn A., Quinn, Joseph F., Peskind, Elaine R., Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P., Kim, Hojoong M., Leverenz, James B., Montine, Thomas J., Ginghina, Carmen, Kang, Un Jung, Cain, Kevin C., Wang, Yu, Aasly, Jan, Goldstein, David, Zhang, Jing

“…Objective: There is a clear need to develop biomarkers for Parkinson disease (PD) diagnosis, differential diagnosis of Parkinsonian disorders, and monitoring…”
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Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies by Wile, Daryl J, Dr, Agarwal, Pankaj A, DM, Schulzer, Michael, Prof, Mak, Edwin, BASc, Dinelle, Katherine, MSc, Shahinfard, Elham, PhD, Vafai, Nasim, MASc, Hasegawa, Kazuko, PhD, Zhang, Jing, Prof, McKenzie, Jessamyn, LPN, Neilson, Nicole, RN, Strongosky, Audrey, BA, Uitti, Ryan J, Prof, Guttman, Mark, MD, Zabetian, Cyrus P, MD, Ding, Yu-Shin, Prof, Adam, Mike, PhD, Aasly, Jan, Prof, Wszolek, Zbigniew K, Prof, Farrer, Matthew, Prof, Sossi, Vesna, Prof, Stoessl, A Jon, Prof

“…Summary Background People with Parkinson's disease can show premotor neurochemical changes in the dopaminergic and non-dopaminergic systems. Using PET, we…”
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The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study by Liu, Shu-Ying, Wile, Daryl J, Fu, Jessie Fanglu, Valerio, Jason, Shahinfard, Elham, McCormick, Siobhan, Mabrouk, Rostom, Vafai, Nasim, McKenzie, Jess, Neilson, Nicole, Perez-Soriano, Alexandra, Arena, Julieta E, Cherkasova, Mariya, Chan, Piu, Zhang, Jing, Zabetian, Cyrus P, Aasly, Jan O, Wszolek, Zbigniew K, McKeown, Martin J, Adam, Michael J, Ruth, Thomas J, Schulzer, Michael, Sossi, Vesna, Stoessl, A Jon

“…Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinson's disease,…”
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Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2 by Pankratz, Nathan, Beecham, Gary W., DeStefano, Anita L., Dawson, Ted M., Doheny, Kimberly F., Factor, Stewart A., Hamza, Taye H., Hung, Albert Y., Hyman, Bradley T., Ivinson, Adrian J., Krainc, Dmitri, Latourelle, Jeanne C., Clark, Lorraine N., Marder, Karen, Martin, Eden R., Mayeux, Richard, Ross, Owen A., Scherzer, Clemens R., Simon, David K., Tanner, Caroline, Vance, Jeffery M., Wszolek, Zbigniew K., Zabetian, Cyrus P., Myers, Richard H., Payami, Haydeh, Scott, William K., Foroud, Tatiana

“…Objective: Genome‐wide association (GWAS) methods have identified genes contributing to Parkinson's disease (PD); we sought to identify additional genes…”
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Evidence for more than one Parkinson's disease-associated variant within the HLA region by Hill-Burns, Erin M, Factor, Stewart A, Zabetian, Cyrus P, Thomson, Glenys, Payami, Haydeh

“…Parkinson's disease (PD) was recently found to be associated with HLA in a genome-wide association study (GWAS). Follow-up GWAS's replicated the PD-HLA…”
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Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease by Shi, Min, Zabetian, Cyrus P., Hancock, Aneeka M., Ginghina, Carmen, Hong, Zhen, Yearout, Dora, Chung, Kathryn A., Quinn, Joseph F., Peskind, Elaine R., Galasko, Douglas, Jankovic, Joseph, Leverenz, James B., Zhang, Jing

“…DJ-1 and α-synuclein are leading biomarkers for Parkinson's disease diagnosis and/or monitoring disease progression. A few recent investigations have…”
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DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease by Lin, Xiangmin, Cook, Travis J., Zabetian, Cyrus P., Leverenz, James B., Peskind, Elaine R., Hu, Shu-Ching, Cain, Kevin C., Pan, Catherine, Edgar, John Scott, Goodlett, David R., Racette, Brad A., Checkoway, Harvey, Montine, Thomas J., Shi, Min, Zhang, Jing

“…DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death and synucleinopathies, including Parkinson disease. Previous…”
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Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease by Palmer, William C, Cholerton, Brenna A, Zabetian, Cyrus P, Montine, Thomas J, Grabowski, Thomas J, Rane, Swati

“…Recently, the cerebellum's role in Parkinson's disease (PD) has been highlighted. Therefore, this study sought to test the hypothesis that functional…”
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Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis by Sheng, Lifu, Stewart, Tessandra, Yang, Dishun, Thorland, Eric, Soltys, David, Aro, Patrick, Khrisat, Tarek, Xie, Zhiying, Li, Na, Liu, Zongran, Tian, Chen, Bercow, Matthew, Matsumoto, Junichi, Zabetian, Cyrus P, Peskind, Elaine, Quinn, Joseph F, Shi, Min, Zhang, Jing

“…Parkinson's disease is a neurodegenerative disorder characterized by the transmission and accumulation of toxic species of α-synuclein (α-syn). Extracellular…”
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The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease by Mata, Ignacio F, Jang, Yongwoo, Kim, Chun-Hyung, Hanna, David S, Dorschner, Michael O, Samii, Ali, Agarwal, Pinky, Roberts, John W, Klepitskaya, Olga, Shprecher, David R, Chung, Kathryn A, Factor, Stewart A, Espay, Alberto J, Revilla, Fredy J, Higgins, Donald S, Litvan, Irene, Leverenz, James B, Yearout, Dora, Inca-Martinez, Miguel, Martinez, Erica, Thompson, Tiffany R, Cholerton, Brenna A, Hu, Shu-Ching, Edwards, Karen L, Kim, Kwang-Soo, Zabetian, Cyrus P

“…To identify the causal gene in a multi-incident U.S. kindred with Parkinson's disease (PD). We characterized a family with a classical PD phenotype in which 7…”
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Evaluation of mild cognitive impairment subtypes in Parkinson's disease by Cholerton, Brenna A., Zabetian, Cyrus P., Wan, Jia Y., Montine, Thomas J., Quinn, Joseph F., Mata, Ignacio F., Chung, Kathryn A., Peterson, Amie, Espay, Alberto J., Revilla, Fredy J., Devoto, Johnna, Watson, G. Stennis, Hu, Shu-Ching, Leverenz, James B., Edwards, Karen L.

“…ABSTRACT Mild cognitive impairment in Parkinson's disease (PD‐MCI) is common and increases the risk for dementia. Establishing distinct PD‐MCI cognitive…”
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Large-scale Exploratory Genetic Analysis of Cognitive Impairment in Parkinson’s Disease by Mata, Ignacio F., PhD, Johnson, Catherine O., PhD, Leverenz, James B., MD, Weintraub, Daniel, MD, Trojanowski, John Q., MD, PhD, Van Deerlin, Vivianna M., MD, PhD, Ritz, Beate, MD, PhD, Rausch, Rebecca, PhD, Factor, Stewart A., DO, Wood-Siverio, Cathy, MS, Quinn, Joseph F., MD, Chung, Kathryn A., MD, Peterson-Hiller, Amie L., MD, Espay, Alberto J., MD, MSc, Revilla, Fredy J., MD, Devoto, Johnna, PsyD, Yearout, Dora, BS, Hu, Shu-Ching, MD, PhD, Cholerton, Brenna A., PhD, Montine, Thomas J., MD, PhD, Edwards, Karen L., PhD, Zabetian, Cyrus P., MD, MS

“…ABSTRACT Cognitive impairment is a common and disabling problem in Parkinson’s disease (PD). Identification of genetic variants that influence the presence or…”
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Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy by Wang, Yu, Hancock, Aneeka M, Bradner, Joshua, Chung, Kathryn A, Quinn, Joseph F, Peskind, Elaine R, Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P, Kim, Hojoong M, Leverenz, James B, Montine, Thomas J, Ginghina, Carmen, Edwards, Karen L, Snapinn, Katherine W, Goldstein, David S, Shi, Min, Zhang, Jing

“…Complement activation, a key component of neuroinflammation, has been reported in both Parkinson's disease (PD) and Alzheimer's disease (AD). However, it is…”
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New windows into the brain: Central nervous system-derived extracellular vesicles in blood by Shi, Min, Sheng, Lifu, Stewart, Tessandra, Zabetian, Cyrus P, Zhang, Jing

“…Extracellular vesicles (EVs), including exosomes and (shedding) microvesicles, are released by nearly all cell types and carry a cargo of proteins and nucleic…”
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Exploring human-genome gut-microbiome interaction in Parkinson’s disease by Wallen, Zachary D., Stone, William J., Factor, Stewart A., Molho, Eric, Zabetian, Cyrus P., Standaert, David G., Payami, Haydeh

“…The causes of complex diseases remain an enigma despite decades of epidemiologic research on environmental risks and genome-wide studies that have uncovered…”
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