Search Results - "Zabetian, C P"

A clinic-based study of the LRRK2 gene in parkinson disease yields new mutations by ZABETIAN, C. P, SAMII, A, MOSLEY, A. D, ROBERTS, J. W, LEIS, B. C, YEAROUT, D, RASKIND, W. H, GRIFFITH, A

“…Referral-based studies indicate that a mutation (G2019S) in exon 41 of the LRRK2 gene might be a common cause of Parkinson disease (PD). The authors sequenced…”
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Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology by Cubells, J F, Zabetian, C P

“…Norepinephrine (NE) is a key neurotransmitter in the central and peripheral nervous systems. Dopamine beta-hydroxylase (DbetaH) catalyzes the synthesis of NE…”
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A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2 by KAY, D. M, STEVENS, C. F, HIGGINS, D. S, GANCHER, S, MOSES, L, ZAREPARSI, S, POORKAJ, P, BIRD, T, NUTT, J, SCHELLENBERG, G. D, PAYAMI, H, HAMZA, T. H, MONTIMURRO, J. S, ZABETIAN, C. P, FACTOR, S. A, SAMII, A, GRIFFITH, A, ROBERTS, J. W, MOLHO, E. S

“…To perform a comprehensive population genetic study of PARK2. PARK2 mutations are associated with juvenile parkinsonism, Alzheimer disease, cancer, leprosy,…”
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Cerebrospinal fluid amyloid β and tau in LRRK2 mutation carriers by AASLY, J. O, SHI, M, KIM, H. M, LEVERENZ, J. B, GINGHINA, C, ARMALY, J, EDWARDS, K. L, SNAPINN, K. W, STOESSL, A. J, ZHANG, J, SOSSI, V, STEWART, T, JOHANSEN, K. K, WSZOLEK, Z. K, UITTI, R. J, HASEGAWA, K, YOKOYAMA, T, ZABETIAN, C. P

“…The goal of the current investigation was to examine a cohort of symptomatic and asymptomatic LRRK2 mutation carriers, in order to address whether the reported…”
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Human PON1, a biomarker of risk of disease and exposure by Furlong, C.E., Suzuki, S.M., Stevens, R.C., Marsillach, J., Richter, R.J., Jarvik, G.P., Checkoway, H., Samii, A., Costa, L.G., Griffith, A., Roberts, J.W., Yearout, D., Zabetian, C.P.

“…Human paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated serum enzyme that exhibits a broad substrate specificity. In addition to protecting…”
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Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease by ZABETIAN, C. P, MORINO, H, ROBERTS, J. W, YEAROUT, D, SAMII, A, KAWAKAMI, H, UJIKE, H, YAMAMOTO, M, ODA, M, MARUYAMA, H, IZUMI, Y, KAJI, R, GRIFFITH, A, LEIS, B. C

“…LRRK2 G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other…”
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Mosaicism of alpha-synuclein gene rearrangements: Report of two unrelated cases of early-onset parkinsonism by Perandones, C, Giugni, J.C, Calvo, D.S, Raina, G.B, De Jorge Lopez, L, Volpini, V, Zabetian, C.P, Mata, I.F, Caputo, M, Corach, D, Radrizzani, M, Micheli, F.E

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Association of cognitive domains with postural instability/gait disturbance in Parkinson's disease by Kelly, V.E, Johnson, C.O, McGough, E.L, Shumway-Cook, A, Horak, F.B, Chung, K.A, Espay, A.J, Revilla, F.J, Devoto, J, Wood-Siverio, C, Factor, S.A, Cholerton, B, Edwards, K.L, Peterson, A.L, Quinn, J.F, Montine, T.J, Zabetian, C.P, Leverenz, J.B

“…Abstract Introduction Research suggests an association between global cognition and postural instability/gait disturbance (PIGD) in Parkinson disease (PD), but…”
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The Structure of Linkage Disequilibrium at the DBH Locus Strongly Influences the Magnitude of Association between Diallelic Markers and Plasma Dopamine β-Hydroxylase Activity by Zabetian, Cyrus P., Buxbaum, Sarah G., Elston, Robert C., Köhnke, Michael D., Anderson, George M., Gelernter, Joel, Cubells, Joseph F.

“…There is currently a great deal of interest in using linkage disequilibrium (LD) mapping to locate both disease and quantitative-trait loci on a genomewide…”
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Hypothesis: Somatic Mosaicism and Parkinson Disease by C, Perandones, LA, Pellene, JC, Giugni, DS, Calvo, RainaGB, SM, Cuevas, IF, Mata, CP, Zabetian, M, Caputo, D, Corach, FE, Micheli, M, Radrizzani

“…KCI Citation Count: 1…”
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A genetic basis for the variable effect of smoking/nicotine on Parkinson’s disease by Hill-Burns, E M, Singh, N, Ganguly, P, Hamza, T H, Montimurro, J, Kay, D M, Yearout, D, Sheehan, P, Frodey, K, Mclear, J A, Feany, M B, Hanes, S D, Wolfgang, W J, Zabetian, C P, Factor, S A, Payami, H

“…Prior studies have established an inverse association between cigarette smoking and the risk of developing Parkinson’s disease (PD), and currently, the…”
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Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease by HAUGARVOLL, K, RADEMAKERS, R, GUIDI, M, RIBOLDAZZI, G, BROWN, L, WALTER, U, BENECKE, R, BERG, D, GASSER, T, THEUNS, J, PALS, P, CRAS, P, KACHERGUS, J. M, DE DEYN, P. Paul, ENGELBORGHS, S, PICKUT, B, UITTI, R. J, FOROUD, T, NICHOLS, W. C, HAGENAH, J, KLEIN, C, SAMII, A, ZABETIAN, C. P, NUYTEMANS, K, BONIFATI, V, VAN BROECKHOVEN, C, FARRER, M. J, WSZOLEK, Z. K, ROSS, O. A, GIBSON, J. M, TAN, E.-K, GAIG, C, TOLOSA, E, GOLDWURM, S

“…Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of Parkinson disease (PD). Several dominantly inherited pathogenic substitutions have…”
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An attempt to replicate interaction between coffee and CYP1A2 gene in connection to Parkinson's disease by Hill-Burns, E. M., Hamza, T. H., Zabetian, C. P., Factor, S. A., Payami, H.

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A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus by Zabetian, Cyrus P., Anderson, George M., Buxbaum, Sarah G., Elston, Robert C., Ichinose, Hiroshi, Nagatsu, Toshiharu, Kim, Kwang-Soo, Kim, Chun-Hyung, Malison, Robert T., Gelernter, Joel, Cubells, Joseph F.

“…Dopamine-β-hydroxylase (DβH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-DβH…”
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Letter to the Editor: Hypothesis: Somatic Mosaicism and Parkinson Disease by Perandones, C, Pellene, L A, Giugni, J C, Calvo, D S, Raina, G B, Cuevas, S M, Mata, I F, Zabetian, C P, Caputo, M, Corach, D, Micheli, F E, Radrizzani, M

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511 PRAZOSIN IMPROVES NIGHTMARES AND SLEEP DISTURBANCE AND DOES NOT WORSEN DAYTIME SYMPTOMS IN POSTTRAUMATIC STRESS DISORDER by Wander, P. L., Raskind, M. A., Zabetian, C. P., Warren, D. J., Kumata, J., Peskind, E. R.

“…BackgroundIn an ongoing parallel-group double-blind placebo-controlled trial at the VA Puget Sound Health Care System, the efficacy of the alpha-1 adrenergic…”
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Phosphorylated α-synuclein in Parkinson's disease by Wang, Yu, Shi, Min, Chung, Kathryn A, Zabetian, Cyrus P, Leverenz, James B, Berg, Daniela, Srulijes, Karin, Trojanowski, John Q, Lee, Virginia M-Y, Siderowf, Andrew D, Hurtig, Howard, Litvan, Irene, Schiess, Mya C, Peskind, Elaine R, Masuda, Masami, Hasegawa, Masato, Lin, Xiangmin, Pan, Catherine, Galasko, Douglas, Goldstein, David S, Jensen, Poul Henning, Yang, Hui, Cain, Kevin C, Zhang, Jing

“…Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human…”
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GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology by TSUANG, Debby, LEVERENZ, James B, KRAMER, Patricia, WOLTJER, Randy, KUKULL, Walter, NELSON, Peter T, JICHA, Gregory A, NELTNER, Janna H, GALASKO, Doug, MASLIAH, Eliezer, TROJANOWSKI, John Q, SCHELLENBERG, Gerard D, LOPEZ, Oscar L, YEAROUT, Dora, HUSTON, Haley, FRITTS-PENNIMAN, Allison, MATA, Ignacio F, WAN, Jia Y, EDWARDS, Karen L, MONTINE, Thomas J, ZABETIAN, Cyrus P, HAMILTON, Ronald L, BENNETT, David A, SCHNEIDER, Julie A, BUCHMAN, Aron S, LARSON, Eric B, CRANE, Paul K, KAYE, Jeffrey A

“…Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized…”
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Functional variants at CYP2A6: New genotyping methods, population genetics, and relevance to studies of tobacco dependence by Zabetian, Cyrus P., Gelernter, Joel, Cubells, Joseph F.

“…Cytochrome P450CYP2A6 (CYP2A6) is the predominant enzyme responsible for the metabolism of nicotine to cotinine. Two variants have been identified that encode…”
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Postural instability/gait disturbance in Parkinson's disease has distinct subtypes: an exploratory analysis by Factor, Stewart A, Steenland, N Kyle, Higgins, Donald S, Molho, Eric S, Kay, Denise M, Montimurro, Jennifer, Rosen, Ami R, Zabetian, Cyrus P, Payami, Haydeh

“…ObjectiveTo test the hypothesis that postural instability with falling (PIF) and freezing of gait (FOG) are distinct subtypes of the postural instability/gait…”
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