Search Results - "Zabell, Adam P.R."

Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase by Zabell, Adam P.R, Corden, Steven, Helquist, Paul, Stauffacher, Cynthia V, Wiest, Olaf

“…The human low molecular weight protein tyrosine phosphatase (HCPTP) is ubiquitously expressed as two isoforms in a wide range of human cells and may be…”
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Diagnostic application of the exponentially modified Gaussian model for peak quality and quantitation in high-throughput liquid chromatography–tandem mass spectrometry by Zabell, Adam P.R., Foxworthy, Tyler, Eaton, Kimberly Napoli, Julian, Randall K.

“…•Peak areas calculated with standard and with EMG methods.•Peak areas compared across four months of production data to observe column trends.•Peaks show a 20%…”
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Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening by Homan, Kristoff T., Balasubramaniam, Deepa, Zabell, Adam P.R., Wiest, Olaf, Helquist, Paul, Stauffacher, Cynthia V.

“…Computational screening with multiple scoring functions was used to identify novel small molecule inhibitors for the human low molecular weight protein…”
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Crystal Structure of the Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6-Å Resolution by Zabell, Adam P.R., Schroff, Alfred D., Bain, Bornadata Evans, Van Etten, Robert L., Wiest, Olaf, Stauffacher, Cynthia V.

“…The crystal structure of HPTP-B, a human isoenzyme of the low molecular weight phosphotyrosyl phosphatase (LMW PTPase) is reported here at a resolution of 1.6…”
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Docking multiple conformations of a flexible ligand into a protein binding site using NMR restraints by Zabell, Adam P.R., Post, Carol Beth

“…A method is described for docking a large, flexible ligand using intra‐ligand conformational restraints from exchange‐transferred NOE (etNOE) data. Numerous…”
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Synthesis of a 5-Azaindole Phosphonic Acid as a Computationally Designed Inhibitor of the Low Molecular Weight Phosphatase HCPTP by Helquist, Paul, V. Stauffacher, Cynthia, A. Weitgenant, Jeremy, Katsuyama, Isamu, A. Bigi, Marinus, J. Corden, Steven, T. Markiewicz, John, P. R. Zabell, Adam, T. Homan, Kristoff, Wiest, Olaf

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Intermolecular relaxation has little effect on intra-peptide exchange-transferred NOE intensities by Zabell, Adam P R, Post, Carol Beth

“…Exchange-transferred nuclear Overhauser enhancement (etNOE) provides a useful method for determining the 3dimensional structure of a ligand bound to a…”
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A proposal to improve calibration and outlier detection in high-throughput mass spectrometry by Zabell, Adam P R, Lytle, Fred E, Julian, Randall K

“…Instrument calibration, required for any accurate quantitative calculation, is a trivial process when performed correctly, but is also full of easily…”
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Accuracy of bound peptide structures determined by exchange transferred nuclear Overhauser data: a simulation study by Eisenmesser, E Z, Zabell, A P, Post, C B

“…The exchange-transferred NOE method to determine the three-dimensional structure of peptides bound to proteins, or other macromolecular systems, is becoming…”
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