Search Results - "Zabel, Claus"

Presymptomatic Alterations in Energy Metabolism and Oxidative Stress in the APP23 Mouse Model of Alzheimer Disease by Hartl, Daniela, Schuldt, Victoria, Forler, Stephanie, Zabel, Claus, Klose, Joachim, Rohe, Michael

“…Glucose hypometabolism is the earliest symptom observed in the brains of Alzheimer disease (AD) patients. In a former study, we analyzed the cortical proteome…”
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Brief Alteration of NMDA or GABAA Receptor-mediated Neurotransmission Has Long Term Effects on the Developing Cerebral Cortex by Kaindl, Angela M., Koppelstaetter, Andrea, Nebrich, Grit, Stuwe, Janine, Sifringer, Marco, Zabel, Claus, Klose, Joachim, Ikonomidou, Chrysanthy

“…Neurotransmitter signaling is essential for physiologic brain development. Sedative and anticonvulsant agents that reduce neuronal excitability via antagonism…”
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A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease by Zabel, Claus, Mao, Lei, Woodman, Ben, Rohe, Michael, Wacker, Maik A, Kläre, Yvonne, Koppelstätter, Andrea, Nebrich, Grit, Klein, Oliver, Grams, Susanne, Strand, Andrew, Luthi-Carter, Ruth, Hartl, Daniela, Klose, Joachim, Bates, Gillian P

“…Huntington disease (HD) is fatal in humans within 15–20 years of symptomatic disease. Although late stage HD has been studied extensively, protein expression…”
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Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function by Trimborn, Marc, Ghani, Mahdi, Walther, Diego J, Dopatka, Monika, Dutrannoy, Véronique, Busche, Andreas, Meyer, Franziska, Nowak, Stefanie, Nowak, Jean, Zabel, Claus, Klose, Joachim, Esquitino, Veronica, Garshasbi, Masoud, Kuss, Andreas W, Ropers, Hans-Hilger, Mueller, Susanne, Poehlmann, Charlotte, Gavvovidis, Ioannis, Schindler, Detlev, Sperling, Karl, Neitzel, Heidemarie

“…Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early…”
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Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype by Hartl, Daniela, Rohe, Michael, Mao, Lei, Staufenbiel, Matthias, Zabel, Claus, Klose, Joachim

“…The amyloid precursor protein (APP) was assumed to be an important neuron-morphoregulatory protein and plays a central role in Alzheimer's disease (AD)…”
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Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease by Diedrich, Madeleine, Kitada, Tohru, Nebrich, Grit, Koppelstaetter, Andrea, Shen, Jie, Zabel, Claus, Klose, Joachim, Mao, Lei

“…Parkinson's disease (PD) is histologically well defined by its characteristic degeneration of dopaminergic neurons in the substantia nigra pars compacta…”
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Proteome analysis of ventral midbrain in MPTP-treated normal and L1cam transgenic mice by Diedrich, Madeleine, Mao, Lei, Bernreuther, Christian, Zabel, Claus, Nebrich, Grit, Kleene, Ralf, Klose, Joachim

“…Treatment of mice by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridene hydrochloride (MPTP) is a well established animal model for Parkinson's disease (PD), while…”
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Aging in Mouse Brain Is a Cell/Tissue-Level Phenomenon Exacerbated by Proteasome Loss by Mao, Lei, Römer, Irmgard, Nebrich, Grit, Klein, Oliver, Koppelstätter, Andrea, Hin, Sascha C, Hartl, Daniela, Zabel, Claus

“…Biological aging is often described by its phenotypic effect on individuals. Still, its causes are more likely found on the molecular level. Biological…”
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Proteomic shifts in embryonic stem cells with gene dose modifications suggest the presence of balancer proteins in protein regulatory networks by Mao, Lei, Zabel, Claus, Herrmann, Marion, Nolden, Tobias, Mertes, Florian, Magnol, Laetitia, Chabert, Caroline, Hartl, Daniela, Herault, Yann, Delabar, Jean Maurice, Manke, Thomas, Himmelbauer, Heinz, Klose, Joachim

“…Large numbers of protein expression changes are usually observed in mouse models for neurodegenerative diseases, even when only a single gene was mutated in…”
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Influence of Huntington's disease on the human and mouse proteome by Zabel, Claus, Klose, Joachim

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Mimetics of a T Cell Epitope Based on Poly-N-acylated Amine Backbone Structures Induce T Cells in Vitro andin Vivo by Hin, Sascha, Bianco, Alberto, Zabel, Claus, Jung, Günther, Walden, Peter

“…Peptidomimetics of the major histocompatibility complex (MHC) class I-restricted ovalbumin-derived T cell epitope SIINFEKL were generated by replacing parts of…”
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Protein extraction for 2DE by Zabel, Claus, Klose, Joachim

“…Our protein extraction protocol for two-dimensional gel electrophoresis (2DE) was updated to meet current needs in the field of proteomics. This protocol…”
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High-resolution large-gel 2DE by Zabel, Claus, Klose, Joachim

“…Our two-dimensional gel electrophoresis (2DE) protocol has been continuously improved in our laboratory since its inception 30 years ago. An updated version is…”
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New Synthetic Non-peptide Ligands for Classical Major Histocompatibility Complex Class I Molecules by Bianco, Alberto, Brock, Carsten, Zabel, Claus, Walk, Tilmann, Walden, Peter, Jung, Günther

“…Poly-N-acylated amines, as a new class of synthetic non-peptide ligands for the murine major histocompatibility complex (MHC) class I molecule H-2Kb, were…”
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Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition by Siebzehnrübl, Florian A., Raber, Kerstin A., Urbach, Yvonne K., Schulze-Krebs, Anja, Canneva, Fabio, Moceri, Sandra, Habermeyer, Johanna, Achoui, Dalila, Gupta, Bhavana, Steindler, Dennis A., Stephan, Michael, Nguyen, Huu Phuc, Bonin, Michael, Riess, Olaf, Bauer, Andreas, Aigner, Ludwig, Couillard-Despres, Sebastien, Paucar, Martin Arce, Svenningsson, Per, Osmand, Alexander, Andreew, Alexander, Zabel, Claus, Weiss, Andreas, Kuhn, Rainer, Moussaoui, Saliha, Blockx, Ines, Van der Linden, Annemie, Cheong, Rachel Y., Roybon, Laurent, Petersén, Åsa, von Hörsten, Stephan

“…Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is…”
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Proteins are specifically altered in disease--really? by Zabel, Claus

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Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders by Zabel, Claus, Nguyen, Huu Phuc, Hin, Sascha C., Hartl, Daniela, Mao, Lei, Klose, Joachim

“…Neurodegenerative disorders (ND) belong to the most devastating diseases in the industrialized western world. Alzheimer disease (AD) is the most prevalent…”
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Kainate Promotes Alterations in Neuronal RNA Splicing Machinery by Rohe, Michael, Nebrich, Grit, Klein, Oliver, Mao, Lei, Zabel, Claus, Klose, Joachim, Hartl, Daniela

“…Kainate, a glutamate analogue, activates kainate and AMPA receptors inducing strong synaptic activation. Systemic kainate application to rodents results in…”
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Animal models in human disease by Zabel, Claus, Klose, Joachim

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Transcriptome and proteome analysis of early embryonic mouse brain development by Hartl, Daniela, Irmler, Martin, Römer, Irmgard, Mader, Michael T, Mao, Lei, Zabel, Claus, de Angelis, Martin Hrabé, Beckers, Johannes, Klose, Joachim

“…Mouse embryonic brain development involves sequential differentiation of multipotent progenitors into neurons and glia cells. Using microarrays and large 2-DE,…”
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