Search Results - "Zaas, Aimee"

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin by Singh, Sheena D, Robbins, Nicole, Zaas, Aimee K, Schell, Wiley A, Perfect, John R, Cowen, Leah E

“…Candida albicans is the leading fungal pathogen of humans, causing life-threatening disease in immunocompromised individuals. Treatment of candidiasis is…”
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PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90 by LaFayette, Shantelle L, Collins, Cathy, Zaas, Aimee K, Schell, Wiley A, Betancourt-Quiroz, Marisol, Gunatilaka, A A Leslie, Perfect, John R, Cowen, Leah E

“…Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful…”
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A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2 by Woods, Christopher W, McClain, Micah T, Chen, Minhua, Zaas, Aimee K, Nicholson, Bradly P, Varkey, Jay, Veldman, Timothy, Kingsmore, Stephen F, Huang, Yongsheng, Lambkin-Williams, Robert, Gilbert, Anthony G, Hero, 3rd, Alfred O, Ramsburg, Elizabeth, Glickman, Seth, Lucas, Joseph E, Carin, Lawrence, Ginsburg, Geoffrey S

“…There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of…”
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Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection by Huang, Yongsheng, Zaas, Aimee K, Rao, Arvind, Dobigeon, Nicolas, Woolf, Peter J, Veldman, Timothy, Øien, N Christine, McClain, Micah T, Varkey, Jay B, Nicholson, Bradley, Carin, Lawrence, Kingsmore, Stephen, Woods, Christopher W, Ginsburg, Geoffrey S, Hero, 3rd, Alfred O

“…Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important…”
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Internal Medicine Resident Perspectives on Virtual Recruitment by O'Connor, Alec B, McGarry, Kelly, Finn, Kathleen M, Harris, Linda, Zaas, Aimee K

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β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study by Hanson, Kimberly E, Pfeiffer, Christopher D, Lease, Erika D, Balch, Alfred H, Zaas, Aimee K, Perfect, John R, Alexander, Barbara D

“…Invasive candidiasis (IC) is a devastating disease. While prompt antifungal therapy improves outcomes, empiric treatment based on the presence of fever has…”
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Host gene expression classifiers diagnose acute respiratory illness etiology by Tsalik, Ephraim L, Henao, Ricardo, Nichols, Marshall, Burke, Thomas, Ko, Emily R, McClain, Micah T, Hudson, Lori L, Mazur, Anna, Freeman, Debra H, Veldman, Tim, Langley, Raymond J, Quackenbush, Eugenia B, Glickman, Seth W, Cairns, Charles B, Jaehne, Anja K, Rivers, Emanuel P, Otero, Ronny M, Zaas, Aimee K, Kingsmore, Stephen F, Lucas, Joseph, Fowler, Jr, Vance G, Carin, Lawrence, Ginsburg, Geoffrey S, Woods, Christopher W

“…Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in…”
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The 2015 International Society for Heart and Lung Transplantation Guidelines for The Management of Fungal Infections in Mechanical Circulatory Support and Cardiothoracic Organ Transplant Recipients: Executive Summary by Husain, Shahid, MD, MS, Sole, Amparo, MD, PhD, Alexander, Barbara D., MD, MHS, Aslam, Saima, MD, MS, Avery, Robin, MD, Benden, Christian, MD, Billaud, Eliane M., PharmD, PhD, Chambers, Daniel, MBBS, MD, Danziger-Isakov, Lara, MD, Fedson, Savitri, MD, Gould, Kate, MD, Gregson, Aric, MD, Grossi, Paolo, MD, PhD, Hadjiliadis, Denis, MD, Hopkins, Peter, MD, Luong, Me-Linh, MD, Marriott, Debbie J.E., MD, Monforte, Victor, MD, Muñoz, Patricia, MD, PhD, Pasqualotto, Alessandro C., MD, PhD, Roman, Antonio, MD, Silveira, Fernanda P., MD, Teuteberg, Jeffrey, MD, MS, Weigt, Stephen, MD, Zaas, Aimee K., MD, MHS, Zuckerman, Andreas, MD, Morrissey, Orla, MD, PhD

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Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease by Cowen, Leah E, Singh, Sheena D, Köhler, Julia R, Collins, Cathy, Zaas, Aimee K, Schell, Wiley A, Aziz, Hamza, Mylonakis, Eleftherios, Perfect, John R, Whitesell, Luke, Lindquist, Susan

“…Invasive fungal infections are a leading cause of mortality among immunocompromised individuals. Treatment is notoriously difficult with the limited…”
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The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance by Shapiro, Rebecca S, Zaas, Aimee K, Betancourt-Quiroz, Marisol, Perfect, John R, Cowen, Leah E

“…The molecular chaperone Hsp90 orchestrates regulatory circuitry governing fungal morphogenesis, biofilm development, drug resistance, and virulence. Hsp90…”
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Breakthrough Invasive Candidiasis in Patients on Micafungin by Pfeiffer, Christopher D, Garcia-Effron, Guillermo, Zaas, Aimee K, Perfect, John R, Perlin, David S, Alexander, Barbara D

“…For Candida species, a bimodal wild-type MIC distribution for echinocandins exists, but resistance to echinocandins is rare. We characterized isolates from…”
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Residency Program Responses to Early COVID-19 Surges Highlight Tension as to Whether Residents Are Learners or Essential Workers by Martin, Shannon K., Finn, Kathleen M., Kisielewski, Michael, Simmons, Rachel, Zaas, Aimee K.

“…Purpose To quantify the extent to which internal medicine (IM) residents provided care for patients with COVID-19 and examine characteristics of residency…”
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Misinterpretation of the American Board of Internal Medicine Leave Policies for Resident Physicians Around Parental Leave by Finn, Kathleen M, Zaas, Aimee K, McDonald, Furman S, Melfe, Michael, Kisielewski, Michael, Willett, Lisa L

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Championing Civility in the Clinical Learning Environment: Evaluation of a Novel Training Program by Shofer, Sharon L, Gagliardi, Jane P, Bryant, Stephanie, Khedagi, Apurva M, Mohottige, Dinushika, Gregory, Ada, Zaas, Aimee K, Truong, Tracy, Staples, Betty B

“…Incivility in the health care workplace is increasing and negatively impacts everyone in the environment, including health care team members and the patients…”
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Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans by Zaas, Aimee K, Chen, Minhua, Varkey, Jay, Veldman, Timothy, Hero, 3rd, Alfred O, Lucas, Joseph, Huang, Yongsheng, Turner, Ronald, Gilbert, Anthony, Lambkin-Williams, Robert, Øien, N Christine, Nicholson, Bradly, Kingsmore, Stephen, Carin, Lawrence, Woods, Christopher W, Ginsburg, Geoffrey S

“…Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers…”
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Salary Equity Among Subspecialty Fellows: A Call to Action by Liao, Solomon, Amin, Alpesh N., Barczi, Steven, Barron, Christine, Degnon, Laura E., Duncan, Jennifer G., Kwan, Brian, Luther, Vera, Moffatt, Mary E., Myers, Angela, O'Rourke, Paul, Vera, Iliana D., Zaas, Aimee K., Solomonides, John

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An individualized predictor of health and disease using paired reference and target samples by Liu, Tzu-Yu, Burke, Thomas, Park, Lawrence P, Woods, Christopher W, Zaas, Aimee K, Ginsburg, Geoffrey S, Hero, Alfred O

“…Consider the problem of designing a panel of complex biomarkers to predict a patient's health or disease state when one can pair his or her current test…”
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A host-based RT-PCR gene expression signature to identify acute respiratory viral infection by Zaas, Aimee K, Burke, Thomas, Chen, Minhua, McClain, Micah, Nicholson, Bradly, Veldman, Timothy, Tsalik, Ephraim L, Fowler, Vance, Rivers, Emanuel P, Otero, Ronny, Kingsmore, Stephen F, Voora, Deepak, Lucas, Joseph, Hero, Alfred O, Carin, Lawrence, Woods, Christopher W, Ginsburg, Geoffrey S

“…Improved ways to diagnose acute respiratory viral infections could decrease inappropriate antibacterial use and serve as a vital triage mechanism in the event…”
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Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling by Shapiro, Rebecca S., Uppuluri, Priya, Zaas, Aimee K., Collins, Cathy, Senn, Heather, Perfect, John R., Heitman, Joseph, Cowen, Leah E.

“…Hsp90 is an environmentally contingent molecular chaperone that influences the form and function of diverse regulators of cellular signaling. Hsp90 potentiates…”
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Plasminogen alleles influence susceptibility to invasive aspergillosis by Zaas, Aimee K, Liao, Guochun, Chien, Jason W, Weinberg, Clarice, Shore, David, Giles, Steven S, Marr, Kieren A, Usuka, Jonathan, Burch, Lauranell H, Perera, Lalith, Perfect, John R, Peltz, Gary, Schwartz, David A

“…Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk…”
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