Search Results - "Zaal, A"

The Influence of Metabolism on Drug Response in Cancer by Zaal, Esther A, Berkers, Celia R

“…Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in the treatment of cancers and occurs in virtually every type of…”
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A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer by Jin, Haojie, Wang, Siying, Zaal, Esther A, Wang, Cun, Wu, Haiqiu, Bosma, Astrid, Jochems, Fleur, Isima, Nikita, Jin, Guangzhi, Lieftink, Cor, Beijersbergen, Roderick, Berkers, Celia R, Qin, Wenxin, Bernards, Rene

“…The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we…”
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Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion by Jansen, Jitske, Jansen, Katja, Neven, Ellen, Poesen, Ruben, Othman, Amr, van Mil, Alain, Sluijter, Joost, Torano, Javier Sastre, Zaal, Esther A., Berkers, Celia R., Esser, Diederik, Wichers, Harry J., van Ede, Karin, van Duursen, Majorie, Burtey, Stéphane, Verhaar, Marianne C., Meijers, Björn, Masereeuw, Rosalinde

“…Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule…”
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SLC1A3 contributes to L‐asparaginase resistance in solid tumors by Sun, Jianhui, Nagel, Remco, Zaal, Esther A, Ugalde, Alejandro Piñeiro, Han, Ruiqi, Proost, Natalie, Song, Ji‐Ying, Pataskar, Abhijeet, Burylo, Artur, Fu, Haigen, Poelarends, Gerrit J, van de Ven, Marieke, van Tellingen, Olaf, Berkers, Celia R, Agami, Reuven

“…L‐asparaginase (ASNase) serves as an effective drug for adolescent acute lymphoblastic leukemia. However, many clinical trials indicated severe ASNase toxicity…”
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Bortezomib resistance in multiple myeloma is associated with increased serine synthesis by Zaal, Esther A, Wu, Wei, Jansen, Gerrit, Zweegman, Sonja, Cloos, Jacqueline, Berkers, Celia R

“…The proteasome inhibitor bortezomib (BTZ) is successfully applied in the treatment of multiple myeloma, but its efficacy is restricted by the wide-spread…”
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Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer by Cibula, D, Abu-Rustum, N.R, Dusek, L, Zikán, M, Zaal, A, Sevcik, L, Kenter, G.G, Querleu, D, Jach, R, Bats, A.S, Dyduch, G, Graf, P, Klat, J, Lacheta, J, Meijer, C.J.L.M, Mery, E, Verheijen, R, Zweemer, R.P

“…Abstract Objective Evaluate prognostic significance of low volume disease detected in sentinel nodes (SN) of patients with early stages cervical cancer…”
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Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37 by Peeters, Rens, Cuenca-Escalona, Jorge, Zaal, Esther A., Hoekstra, Anna T., Balvert, Anouk C. G., Vidal-Manrique, Marcos, Blomberg, Niek, van Deventer, Sjoerd J., Stienstra, Rinke, Jellusova, Julia, Giera, Martin, Hannibal, Luciana, Spiekerkoetter, Ute, ter Beest, Martin, Berkers, Celia R., van Spriel, Annemiek B.

“…The importance of fatty acid (FA) metabolism in cancer is well-established, yet the mechanisms underlying metabolic reprogramming remain elusive. Here, we…”
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P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance by Jiang, Xiangli, Baig, Ali Hyder, Palazzo, Giuliana, Del Pizzo, Rossella, Bortecen, Toman, Groessl, Sven, Zaal, Esther A., Amaya Ramirez, Cinthia Claudia, Kowar, Alexander, Aviles-Huerta, Daniela, Berkers, Celia R., Palm, Wilhelm, Tschaharganeh, Darjus, Krijgsveld, Jeroen, Loayza-Puch, Fabricio

“…Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different…”
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Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation by Chen, Jing, Zaal, Esther A., Berkers, Celia R., Ruijtenbeek, Rob, Garssen, Johan, Redegeld, Frank A.

“…Multiple myeloma (MM) is a hematological malignancy that exhibits aberrantly high levels of proteasome activity. While treatment with the proteasome inhibitor…”
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Modulation of nucleotide metabolism by picornaviruses by Nouwen, Lonneke V, Breeuwsma, Martijn, Zaal, Esther A, van de Lest, Chris H A, Buitendijk, Inge, Zwaagstra, Marleen, Balić, Pascal, Filippov, Dmitri V, Berkers, Celia R, van Kuppeveld, Frank J M

“…Viruses actively reprogram the metabolism of the host to ensure the availability of sufficient building blocks for virus replication and spreading. However,…”
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Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis by de Kivit, Sander, Mensink, Mark, Kostidis, Sarantos, Derks, Rico J.E., Zaal, Esther A., Heijink, Marieke, Verleng, Lotte J., de Vries, Evert, Schrama, Ellen, Blomberg, Niek, Berkers, Celia R., Giera, Martin, Borst, Jannie

“…Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid…”
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Deciphering metabolic crosstalk in context: lessons from inflammatory diseases by Verheijen, Fenne W. M., Tran, Thi N. M., Chang, Jung‐Chin, Broere, Femke, Zaal, Esther A., Berkers, Celia R.

“…Metabolism plays a crucial role in regulating the function of immune cells in both health and disease, with altered metabolism contributing to the pathogenesis…”
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KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment by Sendino Garví, E, van Slobbe, G J J, Zaal, E A, de Baaij, J H F, Hoenderop, J G, Masereeuw, R, Janssen, M J, van Genderen, A M

“…The KCNJ16 gene has been associated with a novel kidney tubulopathy phenotype, viz. disturbed acid-base homeostasis, hypokalemia and altered renal salt…”
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TNFR2 Costimulation Differentially Impacts Regulatory and Conventional CD4 + T-Cell Metabolism by Mensink, Mark, Tran, Thi Ngoc Minh, Zaal, Esther A, Schrama, Ellen, Berkers, Celia R, Borst, Jannie, de Kivit, Sander

“…CD4 conventional T cells (Tconvs) mediate adaptive immune responses, whereas regulatory T cells (Tregs) suppress those responses to safeguard the body from…”
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Clinical outcomes of pelvic exenteration for gynecologic malignancies by Moolenaar, L.R., van Rangelrooij, L.E., van Poelgeest, M.I.E., van Beurden, M., van Driel, W.J., van Lonkhuijzen, L.R.C.W., Mom, C.H., Zaal, A.

“…The aim of this study was to analyze morbidity and survival after pelvic exenteration for gynecologic malignancies and evaluate prognostic factors influencing…”
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Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment by Matamala Montoya, María, van Slobbe, Gijs J J, Chang, Jung-Chin, Zaal, Esther A, Berkers, Celia R

“…Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains an incurable disease, with the…”
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Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis by Jamalpoor, Amer, van Gelder, Charlotte AGH, Yousef Yengej, Fjodor A, Zaal, Esther A, Berlingerio, Sante P, Veys, Koenraad R, Pou Casellas, Carla, Voskuil, Koen, Essa, Khaled, Ammerlaan, Carola ME, Rega, Laura Rita, van der Welle, Reini EN, Lilien, Marc R, Rookmaaker, Maarten B, Clevers, Hans, Klumperman, Judith, Levtchenko, Elena, Berkers, Celia R, Verhaar, Marianne C, Altelaar, Maarten, Masereeuw, Rosalinde, Janssen, Manoe J

“…Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS , encoding the lysosomal transporter cystinosin, resulting in…”
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Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury by Faria, João, Calcat-I-Cervera, Sandra, Skovronova, Renata, Broeksma, Bonnie C, Berends, Alinda J, Zaal, Esther A, Bussolati, Benedetta, O'Brien, Timothy, Mihăilă, Silvia M, Masereeuw, Rosalinde

“…Ischemia/reperfusion injury is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the…”
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Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T‐cells by Zhang, Xiaogang, Greve, Patrick F., Minh, Thi Tran Ngoc, Wubbolts, Richard, Demir, Ayşe Y., Zaal, Esther A., Berkers, Celia R., Boes, Marianne, Stoorvogel, Willem

“…Seminal plasma induces immune tolerance towards paternal allogenic antigens within the female reproductive tract and during foetal development. Recent evidence…”
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Childhood-onset lupus with clinical neurocognitive dysfunction shows lower streamline density and pairwise connectivity on diffusion tensor imaging by Jones, J T, DiFrancesco, M, Zaal, A I, Klein-Gitelman, M S, Gitelman, D, Ying, J, Brunner, H I

“…Objectives The objective of this report is to use diffusion-tensor imaging (DTI) for investigating white-matter connectivity changes associated with…”
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