Search Results - "Zaïr, Zoulikha M"

Effects of glucagon‐like peptide‐1 receptor agonists on histopathological and secondary biomarkers of non‐alcoholic steatohepatitis: A systematic review and meta‐analysis by Borodavkin, Petr, Sheridan, William, Coelho, Claudia, Oštarijaš, Eduard, Zaïr, Zoulikha M., Miras, Alexander D., McGowan, Barbara, Roux, Carel W., Vincent, Royce P., Dimitriadis, Georgios K.

Get full text

Efflux transporter variants as predictors of drug toxicity in lung cancer patients: systematic review and meta-analysis by Zaïr, Zoulikha M, Singer, Donald RJ

“…Chemotherapeutic drugs are underutilized in lung cancer management due in part to serious adverse drug reactions (ADRs). With studies revealing an association…”
Get full text

Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors by Omran, Asma, Leca, Bianca M., Oštarijaš, Eduard, Graham, Natasha, Da Silva, Ana Sofia, Zaïr, Zoulikha M., Miras, Alexander D., le Roux, Carel W., Vincent, Royce P., Cardozo, Linda, Dimitriadis, Georgios K.

“…Background: Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure ⩾130/85 mmHg, fasting blood glucose ⩾5.6…”
Get full text

Clinical Perspectives on Targeting Therapies for Personalized Medicine by Singer, Donald R J, Zaïr, Zoulikha M

“…Expected benefits from new technology include more efficient patient selection for clinical trials, more cost-effective treatment pathways for patients and…”
Get full text

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage by Zaïr, Zoulikha M, Jenkins, Gareth J, Doak, Shareen H, Singh, Raj, Brown, Karen, Johnson, George E

“…Genotoxic tolerance to low-level exposure of monofunctional alkylating agents is compound specific, with the mechanism pertaining to alkyl-induced genotoxic…”
Get full text

Influx transporter variants as predictors of cancer chemotherapy-induced toxicity: systematic review and meta-analysis by Zaïr, Zoulikha M, Singer, Donald RJ

“…Chemotherapeutic agents have been shown to increase lung patient survival, however their use may be limited by their serious adverse effects. We aimed to…”
Get full text

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency by Brüsehafer, Katja, Manshian, Bella B, Doherty, Ann T, Zaïr, Zoulikha M, Johnson, George E, Doak, Shareen H, Jenkins, Gareth J S

“…4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The…”
Get full text

Non-linear dose–response of DNA-reactive genotoxins: Recommendations for data analysis by Johnson, George E., Doak, Shareen H., Griffiths, Sioned M., Quick, Emma L., Skibinski, David O.F., Zaïr, Zoulikha M., Jenkins, Gareth J.

“…Until recently, there has only been a limited amount of data available on the kinetics of mutation induction in the low dose region of exposure. In our…”
Get full text

Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney by Zaïr, Zoulikha M, Eloranta, Jyrki J, Stieger, Bruno, Kullak-Ublick, Gerd A

“…The role of carrier-mediated transport in determining the pharmacokinetics of drugs has become increasingly evident with the discovery of genetic variants that…”
Get more information

Real-time reverse-transcription polymerase chain reaction: technical considerations for gene expression analysis by Doak, Shareen H, Zaïr, Zoulikha M

“…The reverse transcription - polymerase chain reaction (RT-PCR) is a sensitive technique for the quantification of steady-state mRNA levels, particularly in…”
Get more information

Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter by Eloranta, Jyrki J, Zaïr, Zoulikha M, Hiller, Christian, Häusler, Stephanie, Stieger, Bruno, Kullak-Ublick, Gerd A

“…Folates are essential for nucleic acid synthesis and are particularly required in rapidly proliferating tissues, such as intestinal epithelium and hemopoietic…”
Get more information

Non-linear dose-response of DNA-reactive genotoxins: Recommendations for data analysis: Thresholds for Genotoxins and Their Application in Risk Assessment by JOHNSON, George E, DOAK, Shareen H, GRIFFITHS, Sioned M, QUICK, Emma L, SKIBINSKI, David O. F, ZAIR, Zoulikha M, JENKINS, Gareth J

Get full text