Search Results - "ZWINGENBERGER, K."

Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome : A Randomized, double-blind, placebo-controlled trial by HAMURYUDAN, V, MAT, C, SAIP, S, ÖZYAZGAN, Y, SIVA, A, YURDAKUL, S, ZWINGENBERGER, K, YAZICI, H

“…Recurrent oral and genital ulcers are the most frequent problem in the management of the Behçet syndrome. Uncontrolled experience suggests that thalidomide may…”
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Thalidomide as Salvage Therapy for Chronic Graft-Versus-Host Disease by Parker, Pablo M., Chao, Nelson, Nademanee, Auayporn, O'Donnell, Margaret R., Schmidt, Gerhard M., Snyder, David S., Stein, Anthony S., Smith, Eileen P., Molina, Arturo, Stepan, Daniel E., Kashyap, Ashwin, Planas, Ina, Spielberger, Ricardo, Somlo, George, Margolin, Kim, Zwingenberger, K., Wilsman, K., Negrin, Robert S., Long, Gwynn D., Niland, Joyce C., Blume, Karl G., Forman, Stephen J.

“…Thalidomide has been reported to be an effective agent for treatment of chronic graft-versus-host disease (CGVHD). To determine the efficacy of this agent in…”
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Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade by Geitz, Hartmut, Handt, Stefan, Zwingenberger, Kai

“…The mode of action of thalidomide (THD) in clinical cases of vasculitis is still not clear. Expression of adhesion molecules on endothelial cell lines was…”
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Immunomodulation by thalidomide: systematic review of the literature and of unpublished observations by Zwingenberger, K, Wnendt, S

“…Three decades of immunological investigations using thalidomide are reviewed. Both in vitro and in vivo investigations are in accordance with the clinical…”
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Thalidomide's chirality by Wnendt, Stephan, Zwingenberger, Kai

“…Two lines of evidence contradict the hypothesis that use of a pure enantiomer as a drug substance would have prevented the tragedy of thalidomide: the rapid…”
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Synthesis and immunological activity of water-soluble Thalidomide prodrugs by Hess, Sonja, Akermann, Michaela A., Wnendt, Stephan, Zwingenberger, Kai, Eger, Kurt

“…A series of new water-soluble thalidomide prodrugs was prepared. All compounds were derivatized on the nitrogen of the glutarimide ring. Esters of natural…”
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Enantioselective inhibition of TNF-α release by thalidomide and thalidomide-analogues by Wnendt, Stephan, Finkam, Michael, Winter, Werner, Ossig, Joachim, Raabe, Gerd, Zwingenberger, Kai

“…The question whether the immunomodulating activity of rac‐thalidomide resides in either the (−)‐(S)‐ or the (+)‐(R)‐enantiomer was addressed by synthesis and…”
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Effects of a new immunotherapeutic agent (CG5601) on endotoxin-induced uveitis by Porstmann, A U, Zwingenberger, K, Pleyer, U, Baatz, H

“…CG5601 is a novel immunomodulatory substance showing anti-inflammatory properties comparable to thalidomide. To investigate the anti-inflammatory effects of…”
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Thalidomide therapy of established collagen‐induced arthritis (CIA) not accompanied by an evident Th2 shift by HAUSCHILD, A., KROEGER, H., MITCHISON, N. A., UGRINOVIC, S., ZWINGENBERGER, K.

“…Thalidomide, a drug likely to affect the cytokine pattern, was administered orally to mice at various stages of CIA. Treatment (150mg/kg per day by gavage, 5…”
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Extravasation of leukocytes assessed by intravital microscopy: effect of thalidomide by Schneider, J, Bruckmann, W, Zwingenberger, K

“…Thalidomide is very effective in the treatment of idiopathic aphthous stomatitis, characterized by recurrent focal intramucosal leukocytic vasculitis. The mode…”
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Trichinosis: A Prospective Controlled Study of Patients Ten Years After Acute Infection by Harms, G., Binz, P., Feldmeier, H., Zwingenberger, K., Schleehauf, D., Dewes, W., Kress-Hermesdorf, I., Klindworth, C., Bienzle, U.

“…The existence of chronic trichinosis as a disease entity is still a matter of debate. For 10 years after an outbreak of infection with Trichinella spiralis, we…”
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Thalidomide Prolongs Experimental Autoimmune Neuritis in Lewis Rats by Zhu, J, Deng, G M, Diab, A, Zwingenberger, K, Bakhiet, M, Link, H

“…Thalidomide is reported to have immunomodulatory and anti‐inflammatory effects, which have led to its use in the treatment of a number of immune‐mediated…”
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Impaired balance of interleukin-4 and interferon-gamma production in infections with Schistosoma mansoni and intestinal nematodes by Zwingenberger, K, Hohmann, A, de Brito, M C, Ritter, M

“…In chronic infection with Schistosoma mansoni, IL-4 and IFN-gamma are co-modulated in opposite directions. This was shown when testing sera and cell culture…”
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Hepatosplenic schistosomiasis: comparison of sonographic findings in Brazilian and Sudanese patients--correlation of sonographic findings with clinical symptoms by Richter, J, Zwingenberger, K, Ali, Q M, Lima, W de M, Dacal, A R, de Siqueira, G V, Doehring-Schwerdtfeger, E, Feldmeier, H

“…Twenty-seven Brazilian and 32 Sudanese patients with hepatosplenic schistosomiasis from areas where the disease is endemic were examined with ultrasound (US)…”
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Inhibitory effects of thalidomide on cellular proliferation, endoneurial edema and myelin phagocytosis during early Wallerian degeneration by SCHRÖDER, J. M, SELLHAUS, B, WÖHRMANN, T, KÖGEL, B, ZWINGENBERGER, K

“…In addition to the well-known teratogenic effect of thalidomide, previous studies have revealed mild immunosuppressive properties and, more recently, an…”
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Local skin reactivity after induction of Shwartzman reaction in rabbits by Wöhrmann, T., Geist, C., Schneider, J., Matthiesen, T., Zwingenberger, K.

“…A local Shwartzman response was elicited in rabbits by an intradermal injection of the Salmonella typhosa endotoxin lipopolysaccharide (LPS) followed 24 hours…”
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Effects of thalidomide on the local Shwartzman reaction in mice and rabbits by Geist, C., Wöhrmann, T., Schneider, J., Zwingenberger, K.

“…The Shwartzman reaction is an animal model displaying histopathological vasculitis phenomena. Extravasation and swelling due to increased vascular permeability…”
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Thalidomide suppresses T- and B-cell responses to myelin antigen in experimental allergic neuritis by Zhu, J, Bai, X, Mix, E, van der Meide, P H, Zwingenberger, K, Link, H

“…The effects of thalidomide and, for reference, dexamethasone on T- and B-cell functions were assayed in vitro in Lewis rats with experimental allergic neuritis…”
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Tumour necrosis factor in hepatosplenic schistosomiasis by Zwingenberger, K, Irschick, E, Vergetti Siqueira, J G, Correia Dacal, A R, Feldmeier, H

“…Periportal fibroplasia is the dominating feature of hepatosplenic schistosomiasis. Since monokines play an important role in the regulation of fibroplasia,…”
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Release of interleukin 2 and gamma interferon by peripheral mononuclear cells in human Schistosoma mansoni infection normalizes after chemotherapy by Zwingenberger, K, Irschick, E, Siqueira Vergetti, J G, Correia Dacal, A R, Janssen-Rosseck, R, Bienzle, U, Huber, C, Feldmeier, H

“…Interleukin 2 (IL-2) and gamma interferon (IFN-gamma) were determined in supernatants of mitogen- and antigen-driven cell cultures from patients with…”
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