Search Results - "ZWART, Rob"

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood–brain-barrier: Implications for therapy of Alzheimer disease by Bana, Laura, PhD, Minniti, Stefania, PhD, Salvati, Elisa, PhD, Sesana, Silvia, PhD, Zambelli, Vanessa, PhD, Cagnotto, Alfredo, PhD, Orlando, Antonina, PhD, Cazzaniga, Emanuela, PhD, Zwart, Rob, PhD, Scheper, Wiep, PhD, Masserini, Massimo, PhD, Re, Francesca, PhD

“…Abstract Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of Alzheimer's disease (AD). We investigated the ability…”
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Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation by van der Harg, Judith M, Eggels, Leslie, Bangel, Fabian N, Ruigrok, Silvie R, Zwart, Rob, Hoozemans, Jeroen J.M, la Fleur, Susanne E, Scheper, Wiep

“…Abstract Alzheimer's disease (AD) is a highly prevalent multifactorial disease for which Diabetes Mellitus (DM) is a risk factor. Abnormal phosphorylation and…”
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Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmosomal Variants Are Rarely De Novo by van Lint, Freyja H M, Murray, Brittney, Tichnell, Crystal, Zwart, Rob, Amat, Nuria, Lekanne Deprez, Ronald H, Dittmann, Sven, Stallmeyer, Birgit, Calkins, Hugh, van der Smagt, Jasper J, van den Wijngaard, Arthur, Dooijes, Dennis, van der Zwaag, Paul A, Schulze-Bahr, Eric, Judge, Daniel P, Jongbloed, Jan D H, van Tintelen, J Peter, James, Cynthia A

“…Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with pathogenic/likely pathogenic (P/LP) variants in genes encoding the cardiac desmosomal…”
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Disturbed Ca2+ homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro by De Kimpe, Line, Bennis, Anna, Zwart, Rob, van Haastert, Elise S, Hoozemans, Jeroen J M, Scheper, Wiep

“…A major neuropathological hallmark of Alzheimer's disease (AD) is the deposition of aggregated β amyloid (Aβ) peptide in the senile plaques. Aβ is a peptide of…”
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Ubiquilin 2 is not associated with tau pathology by Nölle, Anna, van Haastert, Elise S, Zwart, Rob, Hoozemans, Jeroen J M, Scheper, Wiep

“…Accumulation of aberrant proteins in inclusion bodies is a hallmark of many neurodegenerative diseases. Impairment of proteolytic systems is a common event in…”
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Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison) by Molenaar, Robert Jan, Vreman, Sandra, Hakze-van der Honing, Renate W, Zwart, Rob, de Rond, Jan, Weesendorp, Eefke, Smit, Lidwien A. M., Koopmans, Marion, Bouwstra, Ruth, Stegeman, Arjan, van der Poel, Wim H. M.

“…SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most…”
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Tissue tropism and pathology of highly pathogenic avian influenza H5N6 virus in chickens and Pekin ducks by Vreman, Sandra, Bergervoet, Saskia A., Zwart, Rob, Stockhofe-Zurwieden, Norbert, Beerens, Nancy

“…The highly pathogenic avian influenza (HPAI) H5N6 virus caused outbreaks on commercial poultry farms in the Netherlands in 2017–2018, holding chickens and…”
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PRDM10 directs FLCN expression in a novel disorder overlapping with Birt–Hogg–Dubé syndrome and familial lipomatosis by van de Beek, Irma, Glykofridis, Iris E, Oosterwijk, Jan C, van den Akker, Peter C, Diercks, Gilles F H, Bolling, Maria C, Waisfisz, Quinten, Mensenkamp, Arjen R, Balk, Jesper A, Zwart, Rob, Postma, Alex V, Meijers-Heijboer, Hanne E J, van Moorselaar, R Jeroen A, Wolthuis, Rob M F, Houweling, Arjan C

“…Abstract Birt–Hogg–Dubé syndrome (BHD) is an autosomal dominant disorder characterized by fibrofolliculomas, pulmonary cysts, pneumothoraces and renal cell…”
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Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease by Nijholt, D A T, de Graaf, T R, van Haastert, E S, Oliveira, A Osório, Berkers, C R, Zwart, R, Ovaa, H, Baas, F, Hoozemans, J J M, Scheper, W

“…Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore cellular homeostasis…”
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Arrhythmogenic Right Ventricular Cardiomyopathy-Associated Desmosomal Variants Are Rarely De Novo: Segregation and Haplotype Analysis of a Multinational Cohort by van Lint, Freyja H.M., Murray, Brittney, Tichnell, Crystal, Zwart, Rob, Amat, Nuria, Lekanne Deprez, Ronald H., Dittmann, Sven, Stallmeyer, Birgit, Calkins, Hugh, van der Smagt, Jasper J., van den Wijngaard, Arthur, Dooijes, Dennis, van der Zwaag, Paul A., Schulze-Bahr, Eric, Judge, Daniel P., Jongbloed, Jan D.H., van Tintelen, J. Peter, James, Cynthia A.

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Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms by van Walree, Eva S., Dombrowsky, Gregor, Jansen, Iris E., Mirkov, Maša Umićević, Zwart, Rob, Ilgun, Aho, Guo, Dongchuan, Clur, Sally-Ann B., Amin, Ahmed S., Savage, Jeanne E., van der Wal, Allard C., Waisfisz, Quinten, Maugeri, Alessandra, Wilsdon, Anna, Bu’Lock, Frances A., Hurles, Matthew E., Dittrich, Sven, Berger, Felix, Audain Martinez, Enrique, Christoffels, Vincent M., Hitz, Marc-Philip, Milewicz, Dianna M., Posthuma, Daniëlle, Meijers-Heijboer, Hanne, Postma, Alex V., Mathijssen, Inge B.

“…In this study we aimed to establish the genetic cause of a myriad of cardiovascular defects prevalent in individuals from a genetically isolated population,…”
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Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms by van Walree, Eva S., Dombrowsky, Gregor, Jansen, Iris E., Umićević Mirkov, Maša, Zwart, Rob, Ilgun, Aho, Guo, Dongchuan, Clur, Sally-Ann B., Amin, Ahmed S., Savage, Jeanne E., van der Wal, Allard C., Waisfisz, Quinten, Maugeri, Alessandra, Wilsdon, Anna, Bu'Lock, Frances A., Hurles, Matthew E., Dittrich, Sven, Berger, Felix, Audain Martinez, Enrique, Christoffels, Vincent M., Hitz, Marc-Philip, Milewicz, Dianna M., Posthuma, Daniëlle, Meijers-Heijboer, Hanne, Postma, Alex V., Mathijssen, Inge B.

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Differentiation and proliferation of respiration-deficient human myoblasts by Herzberg, N H, Zwart, R, Wolterman, R A, Ruiter, J P, Wanders, R J, Bolhuis, P A, van den Bogert, C

“…Replication and transcription of mitochondrial DNA were impaired in dividing human myoblasts exposed to ethidium bromide. MtDNA content decreased linearly per…”
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Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease by Elfrink, Hyung Lim, Zwart, Rob, Cavanillas, María L, Schindler, Adam Jay, Baas, Frank, Scheper, Wiep

“…The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER), the first compartment of the secretory pathway. The UPR is…”
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Inhibition of Endoplasmic Reticulum Associ-ated Degradation Reduces Endoplasmic Reticulum Stress and Alters Lysosomal Morphology and Distribution by Hyung Lim Elfrink, Wiep Scheper, Rob Zwart, Frank Baas

“…Disturbances in proteostasis are observed in many neurodegenerative diseases. This leads to activation of protein quality control to restore proteostasis, with…”
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Disturbed Ca.sup.2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer's Disease In Vitro by De Kimpe, Line, Bennis, Anna, Zwart, Rob, van Haastert, Elise S, Hoozemans, Jeroen J. M, Scheper, Wiep

“…A major neuropathological hallmark of Alzheimer's disease (AD) is the deposition of aggregated [beta] amyloid (A[beta]) peptide in the senile plaques. A[beta]…”
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Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution by Elfrink, H.L., Academic Medical Center, Amsterdam, the Netherlands, Zwart, R., Academic Medical Center, Amsterdam, the Netherlands, Baas, F., Academic Medical Center, Amsterdam, the Netherlands, Scheper, W., Academic Medical Center, Amsterdam, the Netherlands

“…Disturbances in proteostasis are observed in many neurodegenerative diseases. This leads to activation of protein quality control to restore proteostasis, with…”
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Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner by Chafekar, Sidhartha M, Hoozemans, Jeroen J M, Zwart, Rob, Baas, Frank, Scheper, Wiep

“…Alzheimer's disease (AD) is characterized by the aggregation of misfolded proteins. Previously we reported activation of the unfolded protein response (UPR) in…”
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Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and A[beta] pathology at the lysosome by De Kimpe, Line, van Haastert, Elise S, Kaminari, Archontia, Zwart, Rob, Rutjes, Helma, Hoozemans, Jeroen J; M, Scheper, Wiep

“…Deposition of aggregated amyloid beta (A[beta]) is a major hallmark of Alzheimerâ[euro](TM)s disease (AD)â[euro]"a common age-related neurodegenerative…”
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Immune Cells in the Porcine Retina: Distribution, Characterization and Morphological Features by Yang, Peizeng, Chen, Ling, Zwart, Rob, Kijlstra, Aize

“…To investigate the presence of immunocompetent cells in the porcine retina and to compare the findings with those obtained earlier in human retinas. Retinal…”
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