Search Results - "ZWANG, Y"

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism by Pines, G, Huang, P H, Zwang, Y, White, F M, Yarden, Y

“…Tumor cells often subvert normal regulatory mechanisms of signal transduction. This study shows this principle by studying yet uncharacterized mutants of the…”
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Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling by SHTIEGMAN, K, KOCHUPURAKKAL, B. S, BENJAMIN, S, CORSO, S, GAN, J, YOSEF, R. B, GIORDANO, S, YARDEN, Y, ZWANG, Y, PINES, G, STARR, A, VEXLER, A, CITRI, A, KATZ, M, LAVI, S, BEN-BASAT, Y

“…Several distinct mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are associated with non-small cell lung cancer, but…”
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Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation by Mosesson, Yaron, Shtiegman, Keren, Katz, Menachem, Zwang, Yaara, Vereb, Gyorgi, Szollosi, Janos, Yarden, Yosef

“…Growth factors stimulate specific receptor tyrosine kinases, but subsequent receptor endocytosis terminates signaling. The ubiquitin ligase c-Cbl targets…”
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Sprouty Fine-Tunes EGF Signaling through Interlinked Positive and Negative Feedback Loops by Rubin, Chanan, Litvak, Vladi, Medvedovsky, Helena, Zwang, Yaara, Lev, Sima, Yarden, Yosef

“…Background: Growth factors and their receptor tyrosine kinases play pivotal roles in development, normal physiology, and pathology. Signal transduction is…”
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Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding by Amit, Ido, Yakir, Liat, Katz, Menachem, Zwang, Yaara, Marmor, Mina D, Citri, Ami, Shtiegman, Keren, Alroy, Iris, Tuvia, Shmuel, Reiss, Yuval, Roubini, Eli, Cohen, Maya, Wides, Ron, Bacharach, Eran, Schubert, Ullrich, Yarden, Yosef

“…The tumor suppressor gene 101 (tsg101) regulates vesicular trafficking processes in yeast and mammals. We report a novel protein, Tal (Tsg101-associated…”
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Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation by Goldberg, Zehavit, Sionov, Ronit Vogt, Berger, Michael, Zwang, Yaara, Perets, Ruth, Van Etten, Richard A., Oren, Moshe, Taya, Yoichi, Haupt, Ygal

“…The p53 tumor suppressor is inhibited and destabilized by Mdm2. However, under stress conditions, this downregulation is relieved, allowing the accumulation of…”
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Polar Expression of ErbB-2/HER2 in Epithelia: Bimodal Regulation by Lin-7 by Shelly, Maya, Mosesson, Yaron, Citri, Ami, Lavi, Sara, Zwang, Yaara, Melamed-Book, Naomi, Aroeti, Benjamin, Yarden, Yosef

“…ErbB-2/HER2 drives epithelial malignancies by forming heterodimers with growth factor receptors. The primordial invertebrate receptor is sorted to the…”
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Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways by Rubin, Chanan, Zwang, Yaara, Vaisman, Nora, Ron, Dina, Yarden, Yosef

“…Sprouty proteins are evolutionarily conserved negative feedback regulators of multiple receptor tyrosine kinases. Mammalian versions of these proteins…”
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Patronizing and Policing Elderly People by Giles, Howard, Zwang-Weissman, Yardena, Hajek, Christopher

“…426 students rated a vignette wherein an older person was patronized (more or less) or not by a police officer. Trait attributions were linearly related to…”
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