Search Results - "ZUPI, Gabriella"

Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus by DEL BUFALO, Donatella, CIUFFREDA, Ludovica, TRISCIUOGLIO, Daniela, DESIDERI, Marianna, COGNETTI, Francesco, ZUPI, Gabriella, MILELLA, Michele

“…Mammalian target of rapamycin (mTOR) is increasingly recognized as a master regulator of fundamental cellular functions, whose deregulation may underlie…”
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Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression by Gabellini, Chiara, Trisciuoglio, Daniela, Desideri, Marianna, Candiloro, Antonio, Ragazzoni, Ylenia, Orlandi, Augusto, Zupi, Gabriella, Del Bufalo, Donatella

“…Abstract We examined the autocrine/paracrine role of interleukin-8 (CXCL8) and the functional significance of CXCL8 receptors, CXCR1 and CXCR2, in human…”
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Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway by Rizzo, Angela, Salvati, Erica, Porru, Manuela, D’Angelo, Carmen, Stevens, Malcolm F., D’Incalci, Maurizio, Leonetti, Carlo, Gilson, Eric, Zupi, Gabriella, Biroccio, Annamaria

“…Functional telomeres are required to maintain the replicative ability of cancer cells and represent putative targets for G-quadruplex (G4) ligands. Here, we…”
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CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery by Guastafierro, Tiziana, Cecchinelli, Barbara, Zampieri, Michele, Reale, Anna, Riggio, Giuseppe, Sthandier, Olga, Zupi, Gabriella, Calabrese, Lilia, Caiafa, Paola

“…Our previous data have shown that in L929 mouse fibroblasts the control of methylation pattern depends in part on poly(ADP-ribosyl)ation and that ADP-ribose…”
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Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect by Salvati, Erica, Leonetti, Carlo, Rizzo, Angela, Scarsella, Marco, Mottolese, Marcella, Galati, Rossella, Sperduti, Isabella, Stevens, Malcolm F G, D'Incalci, Maurizio, Blasco, Maria, Chiorino, Giovanna, Bauwens, Serge, Horard, Béatrice, Gilson, Eric, Stoppacciaro, Antonella, Zupi, Gabriella, Biroccio, Annamaria

“…Functional telomeres are required for the replicability of cancer cells. The G-rich strand of telomeric DNA can fold into a 4-stranded structure known as the…”
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c-Myc Phosphorylation Is Required for Cellular Response to Oxidative Stress by Benassi, Barbara, Fanciulli, Maurizio, Fiorentino, Francesco, Porrello, Alessandro, Chiorino, Giovanna, Loda, Massimo, Zupi, Gabriella, Biroccio, Annamaria

“…Aside from the well-established roles of c-Myc in the regulation of cell cycle, differentiation, and apoptosis, a recent picture is beginning to emerge linking…”
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G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors by LEONETTI, Carlo, SCARSELLA, Marco, MOTTOLESE, Marcella, ANTONIANI, Barbara, GILSON, Eric, ZUPI, Gabriella, BIROCCIO, Annamaria, RIGGIO, Giuseppe, RIZZO, Angela, SALVATI, Erica, D'LNCALCI, Maurizio, STASZEWSKY, Lidia, FRAPOLLI, Roberta, STEVENS, Malcolm F, STOPPACCIARO, Antonella

“…Purpose: The formation of G-quadruplex structures at telomeric DNA sequences blocks telomerase activity, offering an original strategy to design and develop…”
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Growth-Inhibitory and Antiangiogenic Activity of the MEK Inhibitor PD0325901 in Malignant Melanoma with or without BRAF Mutations by Ciuffreda, Ludovica, Del Bufalo, Donatella, Desideri, Marianna, Di Sanza, Cristina, Stoppacciaro, Antonella, Ricciardi, Maria Rosaria, Chiaretti, Sabina, Tavolaro, Simona, Benassi, Barbara, Bellacosa, Alfonso, Foà, Robin, Tafuri, Agostino, Cognetti, Francesco, Anichini, Andrea, Zupi, Gabriella, Milella, Michele

“…The Raf/MEK/ERK pathway is an importantmediator of tumor cell proliferation and angiogenesis. Here, weinvestigated the growth-inhibitory and antiangiogenic…”
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Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells by Trisciuoglio, Daniela, Iervolino, Angela, Zupi, Gabriella, Del Bufalo, Donatella

“…We have previously demonstrated that bcl-2 overexpression in tumor cells exposed to hypoxia increases the expression of vascular endothelial growth factor…”
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Systemic Administration of GPI 15427, a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, Increases the Antitumor Activity of Temozolomide against Intracranial Melanoma, Glioma, Lymphoma by TENTORI, Lucio, LEONETTI, Carlo, GRAZIANI, Grazia, SCARSELLA, Marco, D'AMATI, Giulia, VERGATI, Matteo, PORTARENA, Ilaria, WEIZHENG XU, KALISH, Vincent, ZUPI, Gabriella, JIE ZHANG

“…Purpose: Temozolomide (TMZ) is a DNA methylating agent that has shown promising antitumor activity in recent clinical trials against high grade gliomas,…”
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Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma by Gabellini, Chiara, Castellini, Laura, Trisciuoglio, Daniela, Kracht, Michael, Zupi, Gabriella, Del Bufalo, Donatella

“…We recently reported that bcl-xL regulates interleukin 8 (CXCL8) protein expression and promoter activity in glioblastoma cells. In this paper we demonstrate…”
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The future of antisense therapy: combination with anticancer treatments by Biroccio, Annamaria, Leonetti, Carlo, Zupi, Gabriella

“…The current direction in cancer research is rational drug design, which is based on the evidence that transformed cells are characterized by alterations of…”
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DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents by BIROCCIO, Annamaria, PORRU, Manuela, BERETTA, Giovanni, ZUPI, Gabriella, PISANO, Claudio, ZUNINO, Franco, LEONETTI, Carlo, RIZZO, Angela, SALVATI, Erica, D'ANGELO, Carmen, ORLANDI, Augusto, PASSERI, Daniela, FRANCESCHIN, Marco, STEVENS, Malcolm F. G, GILSON, Eric

“…We previously reported that the G-quadruplex (G4) ligand RHPS4 potentiates the antitumor activity of camptothecins both in vitro and in tumor xenografts. The…”
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Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration by Leonetti, Carlo, Amodei, Sarah, D'Angelo, Carmen, Rizzo, Angela, Benassi, Barbara, Antonelli, Anna, Elli, Raffaella, Stevens, Malcolm F G, D'Incalci, Maurizio, Zupi, Gabriella, Biroccio, Annamaria

“…This study had two goals: 1) to evaluate the biological effect of the novel pentacyclic acridine 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium…”
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Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers by Hugo, Honor, Cures, Alina, Suraweera, Nirosha, Drabsch, Yvette, Purcell, Damian, Mantamadiotis, Theo, Phillips, Wayne, Dobrovic, Alex, Zupi, Gabriella, Gonda, Thomas J., Iacopetta, Barry, Ramsay, Robert G.

“…Although MYB overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival, the basis for this overexpression is unclear…”
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Modulation of bcl-xL in Tumor Cells Regulates Angiogenesis through CXCL8 Expression by Giorgini, Simona, Trisciuoglio, Daniela, Gabellini, Chiara, Desideri, Marianna, Castellini, Laura, Colarossi, Cristina, Zangemeister-Wittke, Uwe, Zupi, Gabriella, Del Bufalo, Donatella

“…In this paper, we investigated whether bcl-xL can be involved in the modulation of the angiogenic phenotype of human tumor cells. Using the ADF human…”
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Bcl-2 overexpression in melanoma cells increases tumor progression-associated properties and in vivo tumor growth by Trisciuoglio, Daniela, Desideri, Marianna, Ciuffreda, Ludovica, Mottolese, Marcella, Ribatti, Domenico, Vacca, Angelo, Del Rosso, Mario, Marcocci, Lucia, Zupi, Gabriella, Del Bufalo, Donatella

“…In this study, we demonstrated that bcl‐2 overexpression in human melanoma cells consistently enhanced the activity of multiple metastasis‐related proteinases,…”
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TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells by Biroccio, Annamaria, Rizzo, Angela, Elli, Raffaella, Koering, Catherine-Elaine, Belleville, Aurélie, Benassi, Barbara, Leonetti, Carlo, Stevens, Malcolm F.G., D’Incalci, Maurizio, Zupi, Gabriella, Gilson, Eric

“…The inhibition of the telomere-binding protein TRF2, by expressing the dominant negative form TRF2 ΔBΔC, has been used as a model of anti-telomere strategy to…”
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Glutathione Depletion Induced by c-Myc Downregulation Triggers Apoptosis on Treatment with Alkylating Agents by Biroccio, Annamaria, Benassi, Barbara, Fiorentino, Francesco, Zupi, Gabriella

“…Here we investigate the mechanism(s) involved in the c-Myc-dependent drug response of melanoma cells. By using three M14-derived c-Myc low-expressing clones,…”
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Treatment of melanoma cells with a bcl-2 bcl-xL antisense oligonucleotide induces antiangiogenic activity by DEL BUFALO, Donatella, TRISCIUOGLIO, Daniela, SCARSELLA, Marco, ZANGEMEISTER-WITTKE, Uwe, ZUPI, Gabriella

“…We have recently reported that bcl-2 overexpression and hypoxia synergistically interact to modulate vascular endothelial growth factor (VEGF) and in vivo…”
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