Search Results - "ZUPI, G"

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy by Salvati, E, Scarsella, M, Porru, M, Rizzo, A, Iachettini, S, Tentori, L, Graziani, G, D'Incalci, M, Stevens, M F G, Orlandi, A, Passeri, D, Gilson, E, Zupi, G, Leonetti, C, Biroccio, A

“…New anti-telomere strategies represent important goals for the development of selective cancer therapies. In this study, we reported that uncapped telomeres,…”
Get full text

Targeting different signaling pathways with antisense oligonucleotides combination for cancer therapy by Leonetti, C, Zupi, G

“…The evidence that cancer development is a complex and multistep process, characterized by alterations of genes involved in the regulation of proliferation,…”
Get more information

Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function by Del Bufalo, D, Rizzo, A, Trisciuoglio, D, Cardinali, G, Torrisi, M R, Zangemeister-Wittke, U, Zupi, G, Biroccio, A

“…Here, we investigated the role of telomerase on Bcl-2-dependent apoptosis. To this end, the 4625 Bcl-2/Bcl-xL bispecific antisense oligonucleotide and the…”
Get full text

Involvement of RB gene family in tumor angiogenesis by Gabellini, C, Del Bufalo, D, Zupi, G

“…Angiogenesis, the development of new blood vessels from pre-existing vessels, represents a fundamental step in tumor progression and metastatization. The…”
Get full text

In vitro and in vivo antitumor efficacy of docetaxel and sorafenib combination in human pancreatic cancer cells by Ulivi, P, Arienti, C, Zoli, W, Scarsella, M, Carloni, S, Fabbri, F, Tesei, A, Chiadini, E, Orlandi, A, Passeri, D, Zupi, G, Milandri, C, Silvestrini, R, Amadori, D, Leonetti, C

“…The response of pancreatic cancer to treatments remains unsatisfactory, highlighting the need for more effective therapeutic regimens. Sorafenib, an orally…”
Get more information

Evaluation of multiple bio‐pathological factors in colorectal adenocarcinomas: Independent prognostic role of p53 and bcl‐2 by Buglioni, Simonetta, D'Agnano, Igea, Cosimelli, Maurizio, Vasselli, Stefania, D'Angelo, Carmen, Tedesco, Manfredo, Zupi, Gabriella, Mottolese, Marcella

“…About 40% of patients with colorectal carcinoma will develop local or distant tumour recurrences. Integrated analyses of bio‐pathological markers, predictive…”
Get full text

relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells by RICCA, A, BIROCCIO, A, TRISCIUOGLIO, D, CIPPITELLI, M, ZUPI, G, DEL BUFALO, D

“…We previously demonstrated that bcl-2 over-expression increases the malignant behaviour of the MCF7 ADR human breast cancer cell line and enhances nuclear…”
Get full text

Bcl-2 has differing effects on the sensitivity of breast cancer cells depending on the antineoplastic drug used by Del Bufalo, D, Biroccio, A, Trisciuoglio, D, Bruno, T, Floridi, A, Aquino, A, Zupi, G

“…The aim of this paper was to evaluate the role of bcl-2 in the susceptibility of the MCF7 ADR human breast carcinoma line overexpressing the P-170 glycoprotein…”
Get full text

406 The BH4 domain is required for proangiogenic function of bcl-2 protein by Gabellini, C, Trisciuoglio, D, Desideri, M, Zupi, G, Del Bufalo, D

Get full text

455 Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90 by Trisciuoglio, D, Gabellini, C, Desideri, M, Ziparo, E, Zupi, G, Del Bufalo, D

Get full text

A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line by Supino, R, Perego, P, Gatti, L, Caserini, C, Leonetti, C, Colantuono, M, Zuco, V, Carenini, N, Zupi, G, Zunino, F

“…Based on the role of p53 in the control of apoptosis following DNA damage, the status of the TP53 gene has been implicated as a major determinant of tumour…”
Get full text

Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells by CITRO, G, SZCZYLIK, C, GINOBBI, P, ZUPI, G, CALABRETTA, B

“…The inhibitory effect of c-myb antisense oligodeoxynucleotides (ODNs) conjugated to folic acid (FA) on HL-60 cell proliferation was examined. Folic acid was…”
Get full text

62 POSTER Expression and functional activity of interleukin-8 receptors on human malignant melanoma cells by Trisciuoglio, D, Gabellini, C, Zupi, G, Del Bufalo, D

Get full text

Inhibition of Leukemia Cell Proliferation by Receptor-Mediated Uptake of c-myb Antisense Oligodeoxynucleotides by Citro, Gennaro, Perrotti, Danilo, Cucco, Carla, D'Agnano, Igea, Sacchi, Ada, Zupi, Gabriella, Calabretta, Bruno

“…Exposure of human leukemia HL-60 cells to an oligodeoxynucleotide complementary to an 18-base sequence (codons 2-7) of c-myb-encoded mRNA has previously been…”
Get full text

Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1 by Gabellini, C, Antonelli, A, Petrinelli, P, Biroccio, A, Marcucci, L, Nigro, G, Russo, G, Zupi, G, Elli, R

“…Individuals affected by ataxia telangiectasia (AT) have a marked susceptibility to cancer. Ataxia telangiectasia cells, in addition to defects in cell cycle…”
Get full text

p53 Nuclear accumulation and multiploidy are adverse prognostic factors in surgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy by BUGLIONI, Simonetta, D'AGNANO, Igea, VASSELLI, Stefania, PERRONE DONNORSO, Raffaele, D'ANGELO, Carmen, BRENNA, Alessia, BENEVOLO, Maria, COSIMELLI, Maurizio, ZUPI, Gabriella, MOTTOLESE, Marcella

“…To identify the prognostically highest risk patients, DNA content and p53 nuclear or cytoplasmic accumulation, evaluated by monoclonal antibody DO7 and…”
Get full text

44 POSTER The BH4 domain is required for proangiogenic function of bcl-2 by Del Bufalo, D, Trisciuoglio, D, Desideri, M, Scarpino, S, Ruco, L, Zupi, G

Get full text

Reversal of adriamycin resistance by lonidamine in a human breast cancer cell line by Citro, G, Cucco, C, Verdina, A, Zupi, G

Get full text

The G-quadruplex ligand RHPS4 interferes with telomere replication leading to ATR-dependent DNA damage response by Biroccio, A, Rizzo, A, Salvati, E, Stevens, M, D'Incalci, M, Ye, J, Gilson, E, Zupi, G

Get full text

441 POSTER The G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors by Biroccio, A, Scarsella, M, Rizzo, A, Mottolese, M, D'Incalci, M, Stoppacciaro, A, Stevens, M, Gilson, E, Zupi, G, Leonetti, C

Get full text