Search Results - "ZUNXUAN CHEN"

Identification of novel isoform-selective inhibitors within class I histone deacetylases by Hu, Erding, Dul, Edward, Sung, Chiu-Mei, Chen, Zunxuan, Kirkpatrick, Robert, Zhang, Gui-Feng, Johanson, Kyung, Liu, Ronggang, Lago, Amparo, Hofmann, Glenn, Macarron, Ricardo, de los Frailes, Maite, Perez, Paloma, Krawiec, John, Winkler, James, Jaye, Michael

“…Histone deacetylases (HDACs) represent an expanding family of protein modifying-enzymes that play important roles in cell proliferation, chromosome remodeling,…”
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Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities by Doe, Chris, Bentley, Ross, Behm, David J, Lafferty, Robert, Stavenger, Robert, Jung, David, Bamford, Mark, Panchal, Terry, Grygielko, Eugene, Wright, Lois L, Smith, Gary K, Chen, Zunxuan, Webb, Christine, Khandekar, Sanjay, Yi, Tracey, Kirkpatrick, Robert, Dul, Edward, Jolivette, Larry, Marino, Jr, Joseph P, Willette, Robert, Lee, Dennis, Hu, Erding

“…Increased Rho kinase (ROCK) activity contributes to smooth muscle contraction and regulates blood pressure homeostasis. We hypothesized that potent and…”
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Expression and functional role of Rho‐kinase in rat urinary bladder smooth muscle by Wibberley, Alexandra, Chen, Zunxuan, Hu, Erding, Hieble, J Paul, Westfall, Timothy D

“…The involvement of Rho‐kinase (ROCK) in the contractile mechanisms mediating smooth muscle contraction of the rat urinary bladder was investigated using…”
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Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor by Hu, Erding, Chen, Zunxuan, Fredrickson, Todd, Zhu, Yuan, Kirkpatrick, Robert, Zhang, Gui-Feng, Johanson, Kyung, Sung, Chiu-Mei, Liu, Ronggang, Winkler, James

“…Histone acetylation alters chromatin state by modifying lysines on histone and plays an important role in modulating gene transcription. A dynamic balance of…”
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Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity by Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

“…The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of…”
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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells by Chen, Zunxuan, Clark, Steven, Birkeland, Marian, Sung, Chiu-Mei, Lago, Amparo, Liu, Ronggang, Kirkpatrick, Robert, Johanson, Kyung, Winkler, James D, Hu, Erding

“…Histone deacetylase (HDAC) inhibitors such as trichostatin (TSA) and butyrate have been shown to inhibit cancer cell proliferation, induce apoptosis and…”
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Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts by Tang, Yi, Chen, Zunxuan, Ambrose, Diane, Liu, Jianhua, Gibbs, Jackson B., Chernoff, Jonathan, Field, Jeffrey

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An Actin Monomer Binding Activity Localizes to the Carboxyl-terminal Half of the Saccharomyces cerevisiae Cyclase-associated Protein (∗) by Freeman, Nancy L., Chen, Zunxuan, Horenstein, Jeffrey, Weber, Annemarie, Field, Jeffrey

“…The Saccharomyces cerevisiae adenylyl cyclase complex contains at least two subunits, a 200-kDa catalytic subunit and a 70-kDa cyclase-associated protein, CAP…”
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A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization by Freeman, Nancy L., Lila, Tom, Mintzer, Keith A., Chen, Zunxuan, Pahk, Albert J., Ren, Ruibao, Drubin, David G., Field, Jeffrey

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Molecular cloning and characterization of profilin-3: a novel cytoskeleton-associated gene expressed in rat kidney and testes by Hu, E, Chen, Z, Fredrickson, T, Zhu, Y

“…Profilin is a small actin-binding protein that is involved in diverse functions such as maintaining cell structure integrity, cell mobility, tumor cell…”
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Rapid isolation of tissue-specific genes from rat kidney by Hu, E, Chen, Z, Fredrickson, T A, Spurr, N, Gentle, S, Sims, M, Zhu, Y, Halsey, W, Van Horn S, Mao, J, Sathe, G M, Brooks, D P

“…A systematic effort to isolate kidney-specific genes was performed using recently described PCR-select methodology. Using this technique, a kidney-specific…”
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Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor by OMER, C. A, ZUNXUAN CHEN, DAVIDE, J. P, ELLIS, M. S, GIBBS, J. B, GREENBERG, I, HAMILTON, K, KOBLAN, K. S, KRAL, A. M, DONGMING LIU, LOBELL, R. B, MILLER, P. J, DIEHL, R. E, MOSSER, S. D, O'NEILL, T. J, RANDS, E, SCHABER, M. D, SENDERAK, E. T, OLIFF, A, KOHL, N. E, CONNER, M. W, CHEN, H. Y, TRUMBAUER, M. E, GOPAL-TRUTER, S, SEEBURGER, G, BHIMNATHWALA, H, ABRAMS, M. T

“…For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme…”
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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) [alpha] and [beta] messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells by Chen, Zunxuan, Clark, Steven, Birkeland, Marian, Sung, Chiu-Mei, Lago, Amparo, Liu, Ronggang, Kirkpatrick, Robert, Johanson, Kyung, Winkler, James D, Hu, Erding

“…Histone deacetylase (HDAC) inhibitors such as trichostatin (TSA) and butyrate have been shown to inhibit cancer cell proliferation, induce apoptosis and…”
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Identification of a novel kidney-specific gene downregulated in acute ischemic renal failure by Hu, E, Chen, Z, Fredrickson, T, Gellai, M, Jugus, M, Contino, L, Spurr, N, Sims, M, Halsey, W, Van Horn, S, Mao, J, Sathe, G, Brooks, D

“…To gain further insights into the molecular mechanisms involved in acute renal failure, we have isolated a new gene from rat and human, named KSP32…”
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