Search Results - "ZUNA, Jan"

Postnatal origin of the chromosomal gains in older patients with high hyperdiploid acute lymphoblastic leukemia by Yang, Minjun, Gunnarsson, Rebeqa, Duployez, Nicolas, Zaliova, Marketa, Zuna, Jan, Johansson, Bertil, Paulsson, Kajsa

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Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort by Zaliova, Marketa, Stuchly, Jan, Winkowska, Lucie, Musilova, Alena, Fiser, Karel, Slamova, Martina, Starkova, Julia, Vaskova, Martina, Hrusak, Ondrej, Sramkova, Lucie, Stary, Jan, Zuna, Jan, Trka, Jan

“…Novel biological subtypes and clinically important genetic aberrations (druggable lesions, prognostic factors) have been described in B-other acute…”
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13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking by Yang, Minjun, Safavi, Setareh, Woodward, Eleanor L., Duployez, Nicolas, Olsson-Arvidsson, Linda, Ungerbäck, Jonas, Sigvardsson, Mikael, Zaliova, Marketa, Zuna, Jan, Fioretos, Thoas, Johansson, Bertil, Nord, Karolin H., Paulsson, Kajsa

“…Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell…”
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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia by Papaemmanuil, Elli, Rapado, Inmaculada, Li, Yilong, Potter, Nicola E, Wedge, David C, Tubio, Jose, Alexandrov, Ludmil B, Van Loo, Peter, Cooke, Susanna L, Marshall, John, Martincorena, Inigo, Hinton, Jonathan, Gundem, Gunes, van Delft, Frederik W, Nik-Zainal, Serena, Jones, David R, Ramakrishna, Manasa, Titley, Ian, Stebbings, Lucy, Leroy, Catherine, Menzies, Andrew, Gamble, John, Robinson, Ben, Mudie, Laura, Raine, Keiran, O'Meara, Sarah, Teague, Jon W, Butler, Adam P, Cazzaniga, Giovanni, Biondi, Andrea, Zuna, Jan, Kempski, Helena, Muschen, Markus, Ford, Anthony M, Stratton, Michael R, Greaves, Mel, Campbell, Peter J

“…Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias…”
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DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch by Novakova, Michaela, Zaliova, Marketa, Fiser, Karel, Vakrmanova, Barbora, Slamova, Lucie, Musilova, Alena, Brüggemann, Monika, Ritgen, Matthias, Fronkova, Eva, Kalina, Tomas, Stary, Jan, Winkowska, Lucie, Svec, Peter, Kolenova, Alexandra, Stuchly, Jan, Zuna, Jan, Trka, Jan, Hrusak, Ondrej, Mejstrikova, Ester

“…Recently, we described B-cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype with early switch to the monocytic lineage and loss of the B-cell…”
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ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity by Zaliova, Marketa, Potuckova, Eliska, Hovorkova, Lenka, Musilova, Alena, Winkowska, Lucie, Fiser, Karel, Stuchly, Jan, Mejstrikova, Ester, Starkova, Julia, Zuna, Jan, Stary, Jan, Trka, Jan

“…-deletions occur recurrently in acute lymphoblastic leukemia, especially in the -rearranged subtype. The -deletion was shown to positively impact prognosis of…”
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Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions by Meyer, Claus, Lopes, Bruno A., Caye-Eude, Aurélie, Cavé, Hélène, Arfeuille, Chloé, Cuccuini, Wendy, Sutton, Rosemary, Venn, Nicola C., Oh, Seung Hwan, Tsaur, Grigory, Escherich, Gabriele, Feuchtinger, Tobias, Kosasih, Hansen J., Khaw, Seong L., Ekert, Paul G., Pombo-de-Oliveira, Maria S., Bidet, Audrey, Djahanschiri, Bardya, Ebersberger, Ingo, Zaliova, Marketa, Zuna, Jan, Zermanova, Zuzana, Juvonen, Vesa, Grümayer, Renate Panzer, Fazio, Grazia, Cazzaniga, Gianni, Larghero, Patrizia, Emerenciano, Mariana, Marschalek, Rolf

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Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies by Cazzaniga, Giovanni, De Lorenzo, Paola, Alten, Julia, Röttgers, Silja, Hancock, Jeremy, Saha, Vaskar, Castor, Anders, Madsen, Hans O, Gandemer, Virginie, Cavé, Hélène, Leoni, Veronica, Köhler, Rolf, Ferrari, Giulia M, Bleckmann, Kirsten, Pieters, Rob, van der Velden, Vincent, Stary, Jan, Zuna, Jan, Escherich, Gabriele, Stadt, Udo Zur, Aricò, Maurizio, Conter, Valentino, Schrappe, Martin, Valsecchi, Maria Grazia, Biondi, Andrea

“…The prognostic value of minimal residual disease (MRD) in Philadelphia-chromosome-positive (Ph+) childhood acute lymphoblastic leukemia (ALL) treated with…”
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Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia by Woodward, Eleanor L., Yang, Minjun, Moura-Castro, Larissa H., van den Bos, Hilda, Gunnarsson, Rebeqa, Olsson-Arvidsson, Linda, Spierings, Diana C. J., Castor, Anders, Duployez, Nicolas, Zaliova, Marketa, Zuna, Jan, Johansson, Bertil, Foijer, Floris, Paulsson, Kajsa

“…High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome…”
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Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols by Cario, Gunnar, Leoni, Veronica, Conter, Valentino, Attarbaschi, Andishe, Zaliova, Marketa, Sramkova, Lucie, Cazzaniga, Gianni, Fazio, Grazia, Sutton, Rosemary, Elitzur, Sarah, Izraeli, Shai, Lauten, Melchior, Locatelli, Franco, Basso, Giuseppe, Buldini, Barbara, Bergmann, Anke K, Lentes, Jana, Steinemann, Doris, Göhring, Gudrun, Schlegelberger, Brigitte, Haas, Oskar A, Schewe, Denis, Buchmann, Swantje, Moericke, Anja, White, Deborah, Revesz, Tamas, Stanulla, Martin, Mann, Georg, Bodmer, Nicole, Arad-Cohen, Nira, Zuna, Jan, Valsecchi, Maria Grazia, Zimmermann, Martin, Schrappe, Martin, Biondi, Andrea

“…ABL-class fusions other than characterize around 2-3% of precursor B-cell acute lymphoblastic leukemia. Case series indicated that patients suffering from…”
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Distinct pattern of genomic breakpoints in CML and BCR::ABL1-positive ALL: analysis of 971 patients by Hovorkova, Lenka, Winkowska, Lucie, Skorepova, Justina, Krumbholz, Manuela, Benesova, Adela, Polivkova, Vaclava, Alten, Julia, Bardini, Michela, Meyer, Claus, Kim, Rathana, Trahair, Toby N, Clappier, Emmanuelle, Chiaretti, Sabina, Henderson, Michelle, Sutton, Rosemary, Sramkova, Lucie, Stary, Jan, Polakova, Katerina Machova, Marschalek, Rolf, Metzler, Markus, Cazzaniga, Giovanni, Cario, Gunnar, Trka, Jan, Zaliova, Marketa, Zuna, Jan

“…The BCR::ABL1 is a hallmark of chronic myeloid leukemia (CML) and is also found in acute lymphoblastic leukemia (ALL). Most genomic breaks on the BCR side…”
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Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia by Zaliova, Marketa, Potuckova, Eliska, Lukes, Julius, Winkowska, Lucie, Starkova, Julia, Janotova, Iveta, Sramkova, Lucie, Stary, Jan, Zuna, Jan, Stanulla, Martin, Zimmermann, Martin, Bornhauser, Beat, Bourquin, Jean-Pierre, Eckert, Cornelia, Cario, Gunnar, Trka, Jan

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Characterization of leukemias with ETV6-ABL1 fusion by Zaliova, Marketa, Moorman, Anthony V, Cazzaniga, Giovanni, Stanulla, Martin, Harvey, Richard C, Roberts, Kathryn G, Heatley, Sue L, Loh, Mignon L, Konopleva, Marina, Chen, I-Ming, Zimmermannova, Olga, Schwab, Claire, Smith, Owen, Mozziconacci, Marie-Joelle, Chabannon, Christian, Kim, Myungshin, Frederik Falkenburg, J H, Norton, Alice, Marshall, Karen, Haas, Oskar A, Starkova, Julia, Stuchly, Jan, Hunger, Stephen P, White, Deborah, Mullighan, Charles G, Willman, Cheryl L, Stary, Jan, Trka, Jan, Zuna, Jan

“…To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and…”
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Intragenic ERG Deletions Do Not Explain the Biology of ERG-Related Acute Lymphoblastic Leukemia by Potuckova, Eliska, Zuna, Jan, Hovorkova, Lenka, Starkova, Julia, Stary, Jan, Trka, Jan, Zaliova, Marketa

“…Intragenic ERG deletions occur in 3-5% of B-cell precursor acute lymphoblastic leukemia, specifically in B-other subtype lacking the classifying genetic…”
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Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia by van Delft, Frederik W., Horsley, Sharon, Colman, Sue, Anderson, Kristina, Bateman, Caroline, Kempski, Helena, Zuna, Jan, Eckert, Cornelia, Saha, Vaskar, Kearney, Lyndal, Ford, Anthony, Greaves, Mel

“…B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1) fusion has an overall good prognosis, but relapses occur, usually after…”
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New biological and genetic classification and therapeutically relevant categories in childhood B-cell precursor acute lymphoblastic leukemia by Starý, Jan, Zuna, Jan, Zaliova, Marketa

“…Traditionally, genetic abnormalities detected by conventional karyotyping, fluorescence hybridization, and polymerase chain reaction divided childhood B-cell…”
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P397: IKZF1 ALTERATIONS HAVE A NEGATIVE IMPACT ON EARLY MOLECULAR RESPONSE AND SURVIVAL OF ADULT PATIENTS WITH B‐CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA TREATED WITH GMALL 07/2003 PROTOCOL IN CZECHIA by Polivkova, Vaclava, Hrabovsky, Stepan, Vrzalova, Zuzana, Stika, Jiri, Horacek, Jan, Pecherková, Pavla, Halamova, Hana, Zuna, Jan, Trka, Jan, Fronkova, Eva, Zaliova, Marketa, Doubek, Michael, Machova Polakova, Katerina, Salek, Cyril

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Acute lymphoblastic leukemia with aleukemic prodrome: preleukemic dynamics and possible mechanisms of immunosurveillance by Zimmermannova, Olga, Zaliova, Marketa, Moorman, Anthony V, Al-Shehhi, Halima, Fronkova, Eva, Zemanova, Zuzana, Kalina, Tomas, Vora, Ajay, Stary, Jan, Trka, Jan, Hrusak, Ondrej, Zuna, Jan

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Chimeric JAK2 Kinases Trigger Non‐uniform Changes of Cellular Metabolism in BCR‐ABL1‐like Childhood ALL by Lukes, Julius, Potuckova, Eliska, Alquezar‐Artieda, Natividad, Hermanova, Ivana, Kosanovic, Sladjana, Hlozkova, Katerina, Alberich Jorda, Meritxell, Zuna, Jan, Trka, Jan, Tennant, Daniel A., Stanulla, Martin, Zaliova, Marketa, Starkova, Julia

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Identification of Fusion Gene Breakpoints is Feasible and Facilitates Accurate Sensitive Minimal Residual Disease Monitoring on Genomic Level in Patients With PML‐RARA, CBFB‐MYH11, and RUNX1‐RUNX1T1 by Lukes, Julius, Winkowska, Lucie, Zwyrtkova, Martina, Starkova, Julia, Sramkova, Lucie, Stary, Jan, Trka, Jan, Zuna, Jan, Zaliova, Marketa

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