Search Results - "ZUGNO, ALEXANDRA I."

Gut microbiota–brain axis in depression: The role of neuroinflammation by Carlessi, Anelise S., Borba, Laura A., Zugno, Alexandra I., Quevedo, João, Réus, Gislaine Z.

“…Major depressive disorder (MDD) is a psychiatric condition that affects a large number of people in the world, and the treatment existents do not work for all…”
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The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia by Réus, Gislaine Z., Becker, Indianara R.T., Scaini, Giselli, Petronilho, Fabricia, Oses, Jean P., Kaddurah-Daouk, Rima, Ceretta, Luciane B., Zugno, Alexandra I., Dal-Pizzol, Felipe, Quevedo, João, Barichello, Tatiana

“…Evidence has shown that the kynurenine pathway (KP) plays a role in the onset of oxidative stress and also in the pathophysiology of schizophrenia. The aim of…”
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Eating Disorder Risks Associated with Time Spent Using Social Media at an AMREC Population in the Coal Mining Region of Santa Catarina by Damázio, Louyse S, Frutuoso, Eduarda B, Zilli, João Pedro S, Ivanov, Yuri Aleksander, Cancillier, Sarah G, Quevedo, João, Zugno, Alexandra I

“…Comparing one's appearance to other people's and believing in an ideal body shape can negatively impact an individual. The probability of developing ED in…”
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Schizophrenia-like behavior is not altered by melatonin supplementation in rodents by AFONSO, ARLINDO C., PACHECO, FELIPE D., CANEVER, LARA, WESSLER, PATRICIA G., MASTELLA, GUSTAVO A., GODOI, AMANDA K., HUBBE, ISABELA, BISCHOFF, LAURA M., BIALECKI, ALEX VICTOR S., ZUGNO, ALEXANDRA I.

“…Abstract An emerging area in schizophrenia research focuses on the impact of immunomodulatory drugs such as melatonin, which have played important roles in…”
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Pre-clinical investigation of Diabetes Mellitus as a risk factor for schizophrenia by Heylmann, Alexandra S. Almeida, Canever, Lara, Gress, Katia, Gomes, Sarah T., Fachim, Isadora, Michels, Carolina, Stopassoli, Geórgia C., Mastella, Gustavo A., Steckert, Amanda V., Damiani, Adriani P., de Andrade, Vanessa M., Quevedo, João, Zugno, Alexandra I.

“…•Type 1 Diabetes Mellitus can be considered a predisposing factor for schizophrenia.•Association alloxan+ketamine induced deficit in social interaction between…”
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The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine by Damazio, Louyse S, Silveira, Flávia R, Canever, Lara, Castro, Adalberto A DE, Estrela, Jadne M, Budni, Josiane, Zugno, Alexandra I

“…Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and…”
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Oxidative Mechanisms of Brain Dysfunction During Sepsis by Dal-Pizzol, Felipe, Ritter, Cristiane, Cassol-Jr, Omar J., Rezin, Gislaine T., Petronilho, Fabrícia, Zugno, Alexandra I., Quevedo, João, Streck, Emilio L.

“…Oxidative stress has drawn a lot of attention in the past few decades, since it has been reported to participate in the mechanism of many diseases. Therefore,…”
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Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration by Fraga, Daiane B, Réus, Gislaine Z, Abelaira, Helena M, De Luca, Renata D, Canever, Leila, Pfaffenseller, Bianca, Colpo, Gabriela D, Kapczinski, Flávio, Quevedo, João, Zugno, Alexandra I

“…To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days…”
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Olfactory deficit as a result of clozapine withdrawal syndrome in an animal model of schizophrenia: preliminary results by Pacheco, Felipe D, Silva, Mauricio L DA, Batista, Graziela, Santos, Witória, Castro, Adalberto A DE, Canever, Lara, Zugno, Alexandra I

“…Clozapine is an antipsychotic that produces serious withdrawal effects in schizophrenic patients. Olfactory deficits are well known as part of negative…”
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Tamoxifen effects on respiratory chain complexes and creatine kinase activities in an animal model of mania by Moretti, Morgana, Valvassori, Samira S., Steckert, Amanda V., Rochi, Natalia, Benedet, Joana, Scaini, Giselli, Kapczinski, Flávio, Streck, Emilio L., Zugno, Alexandra I., Quevedo, João

“…The present study aimed to investigate the effects of tamoxifen (TMX) on locomotor behavior and on the activities of mitochondrial respiratory chain complexes…”
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Effects of omega-3 supplementation on interleukin and neurotrophin levels in an animal model of schizophrenia by Zugno, Alexandra I, Canever, Lara, Mastella, Gustavo, Heylmann, Alexandra S, Oliveira, Mariana B, Steckert, Amanda V, Castro, Adalberto A, dal Pizzol, Felipe, Quevedo, João, Gama, Clarissa S

“…New studies suggest that polyunsaturated fatty acids, such as omega-3, may reduce the symptoms of schizophrenia. The present study evaluated the preventive…”
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Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats by Teodorak, Brena P, Ferreira, Gabriela K, Scaini, Giselli, Wessler, Letícia B, Heylmann, Alexandra S, Deroza, Pedro, Valvassori, Samira S, Zugno, Alexandra I, Quevedo, João, Streck, Emilio L

“…Fenproporex is the second most commonly amphetamine-based anorectic consumed worldwide; this drug is rapidly converted into amphetamine, in vivo, and acts by…”
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Mitochondrial Dysfunction and Psychiatric Disorders by Rezin, Gislaine T., Amboni, Graziela, Zugno, Alexandra I., Quevedo, João, Streck, Emilio L.

“…Mitochondrial oxidative phosphorylation is the major ATP-producing pathway, which supplies more than 95% of the total energy requirement in the cells. Damage…”
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Guanidinoacetate Decreases Antioxidant Defenses and Total Protein Sulfhydryl Content in Striatum of Rats by Zugno, Alexandra I., Stefanello, Francieli M., Scherer, Emilene B. S., Mattos, Cristiane, Pederzolli, Carolina D., Andrade, Vanessa M., Wannmacher, Clovis M. D., Wajner, Moacir, Dutra-Filho, Carlos S., Wyse, Angela T. S.

“…Guanidinoacetate methyltransferase (GAMT) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of…”
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Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats by Simões, Lutiana Roque, Sangiogo, Gustavo, Tashiro, Michael Hikaru, Generoso, Jaqueline S., Faller, Cristiano Julio, Dominguini, Diogo, Mastella, Gustavo Antunes, Scaini, Giselli, Giridharan, Vijayasree Vayalanellore, Michels, Monique, Florentino, Drielly, Petronilho, Fabricia, Réus, Gislaine Zilli, Dal-Pizzol, Felipe, Zugno, Alexandra I., Barichello, Tatiana

“…Evidence suggest that prenatal immune system disturbance contributes largely to the pathophysiology of neuropsychiatric disorders. We investigated if maternal…”
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In vivo and in vitro effects of fructose on rat brain acetylcholinesterase activity: an ontogenetic study by Guimarães, Carine A, Biella, Mairis S, Lopes, Abigail, Deroza, Pedro F, Oliveira, Mariana B, Macan, Tamires P, Streck, Emilio L, Ferreira, Gustavo C, Zugno, Alexandra I, Schuck, Patrícia F

“…Increased fructose concentrations are the biochemical hallmark of fructosemia, a group of inherited disorders on the metabolic pathway of this sugar. The main…”
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Effects of paradoxical sleep deprivation on oxidative parameters in the serum and brain of mice submitted to the animal model of hyperglycemia by Rosa, Júlia Panato-Da, Sandrini, Isadora Gava, Possamai-Della, Taise, Aguiar-Geraldo, Jorge M., Machado-Laureano, Maria Luísa, Zugno, Alexandra I., Quevedo, João, Valvassori, Samira S.

“…The present study aimed to investigate the effects of paradoxical sleep deprivation (PSD) on behavioral and oxidative stress parameters in the brain and serum…”
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Sepsis sensitizes behavioural amphetamine responses while inducing inflammatory and neurotrophic vulnerability in the cecal ligation and puncture model by Valvassori, Samira S., Possamai‐Della, Taise, Aguiar‐Geraldo, Jorge M., Sant'Ana, Rômulo Goronci, Dal‐Pont, Gustavo C., Pescador, Bruna, Zugno, Alexandra I., Quevedo, João, Dal‐Pizzol, Felipe

“…The present study aimed to evaluate if sepsis sensitizes behavioural and biochemical responses induced by m‐amphetamine. For this, Wistar rats were submitted…”
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Methylmalonate administration decreases Na+,K+-ATPase activity in cerebral cortex of rats by Wyse, Angela T. S, Streck, Emílio L, Barros, Sonja V.T, Brusque, Ana M, Zugno, Alexandra I, Wajner, Moacir

“…Buffered methylmalonate (MMA) was injected s.c. into rats twice a day at 8 h intervals from 5 to 25 days of age (chronic treatment), or into 10-day-old rats…”
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Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics by Possamai-Della, Taise, Cararo, José Henrique, Aguiar-Geraldo, Jorge M., Peper-Nascimento, Jefté, Zugno, Alexandra I., Fries, Gabriel R., Quevedo, João, Valvassori, Samira S.

“…Preclinical genetic studies have related stress early exposures with changes in gene regulatory mechanisms, including epigenetic alterations, such as…”
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