Search Results - "ZORZANO, ANTONIO"

Metabolic implications of organelle–mitochondria communication by Gordaliza‐Alaguero, Isabel, Cantó, Carlos, Zorzano, Antonio

“…Cellular organelles are not static but show dynamism—a property that is likely relevant for their function. In addition, they interact with other organelles in…”
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Mitochondrial Dynamics in Mammalian Health and Disease by Liesa, Marc, Palacin, Manuel, Zorzano, Antonio

“…Institute for Research in Biomedicine (IRB Barcelona), CIBER de Diabetes y Enfermedades Metabólicas Asociadas, and Departament de Bioquímica i Biologia…”
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SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity by Keiran, Noelia, Ceperuelo-Mallafré, Victoria, Calvo, Enrique, Hernández-Alvarez, Maria Isabel, Ejarque, Miriam, Núñez-Roa, Catalina, Horrillo, Daniel, Maymó-Masip, Elsa, Rodríguez, M. Mar, Fradera, Rosa, de la Rosa, Juan Vladimir, Jorba, Rosa, Megia, Ana, Zorzano, Antonio, Medina-Gómez, Gema, Serena, Carolina, Castrillo, Antonio, Vendrell, Joan, Fernández-Veledo, Sonia

“…Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1 (SUNCR1). The accumulation of succinate in macrophages is known to activate…”
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The effects of ENDOG on lipid metabolism may be tissue-dependent and may not require its translocation from mitochondria by Llovera, Marta, Gouveia, Leonor, Zorzano, Antonio, Sanchis, Daniel

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Differential control of muscle mass in type 1 and type 2 diabetes mellitus by Sala, David, Zorzano, Antonio

“…Diabetes mellitus—whether driven by insulin deficiency or insulin resistance—causes major alterations in muscle metabolism. These alterations have an impact on…”
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Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease by di Domenico, Angelique, Carola, Giulia, Calatayud, Carles, Pons-Espinal, Meritxell, Muñoz, Juan Pablo, Richaud-Patin, Yvonne, Fernandez-Carasa, Irene, Gut, Marta, Faella, Armida, Parameswaran, Janani, Soriano, Jordi, Ferrer, Isidro, Tolosa, Eduardo, Zorzano, Antonio, Cuervo, Ana Maria, Raya, Angel, Consiglio, Antonella

“…Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A…”
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Mfn2 is critical for brown adipose tissue thermogenic function by Boutant, Marie, Kulkarni, Sameer S, Joffraud, Magali, Ratajczak, Joanna, Valera‐Alberni, Miriam, Combe, Roy, Zorzano, Antonio, Cantó, Carles

“…Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and…”
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Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease by Hernández-Alvarez, María Isabel, Sebastián, David, Vives, Sara, Ivanova, Saška, Bartoccioni, Paola, Kakimoto, Pamela, Plana, Natalia, Veiga, Sónia R., Hernández, Vanessa, Vasconcelos, Nuno, Peddinti, Gopal, Adrover, Anna, Jové, Mariona, Pamplona, Reinald, Gordaliza-Alaguero, Isabel, Calvo, Enrique, Cabré, Noemí, Castro, Rui, Kuzmanic, Antonija, Boutant, Marie, Sala, David, Hyotylainen, Tuulia, Orešič, Matej, Fort, Joana, Errasti-Murugarren, Ekaitz, Rodrígues, Cecilia M.P., Orozco, Modesto, Joven, Jorge, Cantó, Carles, Palacin, Manuel, Fernández-Veledo, Sonia, Vendrell, Joan, Zorzano, Antonio

“…Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver…”
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Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes by Zorzano, Antonio, Liesa, Marc, Palacín, Manuel

“…Mitochondrial dysfunction has been reported in skeletal muscle of obese subjects and of type 2 diabetic patients. Reduced mitochondrial mass and defective…”
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L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction by Errasti-Murugarren, Ekaitz, Fort, Joana, Bartoccioni, Paola, Díaz, Lucía, Pardon, Els, Carpena, Xavier, Espino-Guarch, Meritxell, Zorzano, Antonio, Ziegler, Christine, Steyaert, Jan, Fernández-Recio, Juan, Fita, Ignacio, Palacín, Manuel

“…L-amino acid transporters (LATs) play key roles in human physiology and are implicated in several human pathologies. LATs are asymmetric amino acid exchangers…”
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Hypoxia-induced HIF1α activation regulates small extracellular vesicle release in human embryonic kidney cells by Muñiz-García, Ana, Romero, Montserrat, Falcόn-Perez, Juan Manuel, Murray, Patricia, Zorzano, Antonio, Mora, Silvia

“…Extracellular vesicles (EVs) are membrane enclosures released by eukaryotic cells that carry bioactive molecules and serve to modulate biological responses in…”
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The sensing of mitochondrial DAMPs by non-immune cells by Rodríguez-Nuevo, Aida, Zorzano, Antonio

“…Mitochondria are the source of damage-associated molecular patterns (DAMPs), which are molecules that play a key modulatory role in immune cells. These…”
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Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway by Sebastián, David, Sorianello, Eleonora, Segalés, Jessica, Irazoki, Andrea, Ruiz-Bonilla, Vanessa, Sala, David, Planet, Evarist, Berenguer-Llergo, Antoni, Muñoz, Juan Pablo, Sánchez-Feutrie, Manuela, Plana, Natàlia, Hernández-Álvarez, María Isabel, Serrano, Antonio L, Palacín, Manuel, Zorzano, Antonio

“…Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major contributors to aging. However, the molecular mechanisms responsible…”
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High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria by Lionetti, Lillà, Mollica, Maria Pina, Donizzetti, Immacolata, Gifuni, Giorgio, Sica, Raffaella, Pignalosa, Angelica, Cavaliere, Gina, Gaita, Marcello, De Filippo, Chiara, Zorzano, Antonio, Putti, Rosalba

“…Mitochondria are dynamic organelles that frequently undergo fission and fusion processes, and imbalances in these processes may be involved in obesity and…”
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Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity by Tur, Juan, Pereira-Lopes, Selma, Vico, Tania, Marín, Eros A., Muñoz, Juan P., Hernández-Alvarez, Maribel, Cardona, Pere-Joan, Zorzano, Antonio, Lloberas, Jorge, Celada, Antonio

“…Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that…”
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Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function by Penna, Fabio, Ballarò, Riccardo, Martinez-Cristobal, Paula, Sala, David, Sebastian, David, Busquets, Silvia, Muscaritoli, Maurizio, Argilés, Josep M., Costelli, Paola, Zorzano, Antonio

“…Cancer cachexia is a multifactorial syndrome characterized by anorexia, weight loss and muscle wasting that impairs patients' quality of life and survival. Aim…”
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Prevalence of peri-implant inflammatory disease in patients with a history of periodontal disease who receive supportive periodontal therapy by Aguirre-Zorzano, Luis Antonio, Estefanía-Fresco, Ruth, Telletxea, Olatz, Bravo, Manuel

“…Objectives To describe the status of implants in periodontally compromised patients who regularly receive supportive periodontal therapy (SPT) and to determine…”
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Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation by Irazoki, Andrea, Gordaliza-Alaguero, Isabel, Frank, Emma, Giakoumakis, Nikolaos Nikiforos, Seco, Jordi, Palacín, Manuel, Gumà, Anna, Sylow, Lykke, Sebastián, David, Zorzano, Antonio

“…Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA recognition by intracellular DNA sensors. However, the…”
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Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism by Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., McQueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.

“…The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and…”
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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis by Sebastián, David, Hernández-Alvarez, María Isabel, Segalés, Jessica, Sorianello, Eleonora, Muñoz, Juan Pablo, Sala, David, Waget, Aurélie, Liesa, Marc, Paz, José C, Gopalacharyulu, Peddinti, Orešič, Matej, Pich, Sara, Burcelin, Rémy, Palacín, Manuel, Zorzano, Antonio

“…Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly…”
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