Search Results - "ZORKOLTSEVA, Irina V"

Gene-based association analysis identifies 190 genes affecting neuroticism by Belonogova, Nadezhda M., Zorkoltseva, Irina V., Tsepilov, Yakov A., Axenovich, Tatiana I.

“…Neuroticism is a personality trait, which is an important risk factor for psychiatric disorders. Recent genome-wide studies reported about 600 genes…”
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sumSTAAR: A flexible framework for gene-based association studies using GWAS summary statistics by Belonogova, Nadezhda M, Svishcheva, Gulnara R, Kirichenko, Anatoly V, Zorkoltseva, Irina V, Tsepilov, Yakov A, Axenovich, Tatiana I

“…Gene-based association analysis is an effective gene-mapping tool. Many gene-based methods have been proposed recently. However, their power depends on the…”
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Genetic determinants of circulating sphingolipid concentrations in European populations by Hicks, Andrew A, Pramstaller, Peter P, Johansson, Asa, Vitart, Veronique, Rudan, Igor, Ugocsai, Peter, Aulchenko, Yurii, Franklin, Christopher S, Liebisch, Gerhard, Erdmann, Jeanette, Jonasson, Inger, Zorkoltseva, Irina V, Pattaro, Cristian, Hayward, Caroline, Isaacs, Aaron, Hengstenberg, Christian, Campbell, Susan, Gnewuch, Carsten, Janssens, A Cecilej W, Kirichenko, Anatoly V, König, Inke R, Marroni, Fabio, Polasek, Ozren, Demirkan, Ayse, Kolcic, Ivana, Schwienbacher, Christine, Igl, Wilmar, Biloglav, Zrinka, Witteman, Jacqueline C M, Pichler, Irene, Zaboli, Ghazal, Axenovich, Tatiana I, Peters, Annette, Schreiber, Stefan, Wichmann, H-Erich, Schunkert, Heribert, Hastie, Nick, Oostra, Ben A, Wild, Sarah H, Meitinger, Thomas, Gyllensten, Ulf, van Duijn, Cornelia M, Wilson, James F, Wright, Alan, Schmitz, Gerd, Campbell, Harry

“…Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several…”
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The apolipoprotein E gene and its age-specific effects on cognitive function by Liu, Fan, Pardo, Luba M, Schuur, Maaike, Sanchez-Juan, Pascual, Isaacs, Aaron, Sleegers, Kristel, de Koning, Ingrid, Zorkoltseva, Irina V, Axenovich, Tatiana I, Witteman, Jacqueline C.M, Janssens, A. Cecile J.W, van Swieten, John C, Aulchenko, Yurii S, Oostra, Ben A, van Duijn, Cornelia M

“…Abstract The E4 allele of the apolipoprotein E gene ( APOE ) is a well-established determinant of Alzheimer's disease but its relation to cognitive function is…”
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A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy by Silva, Claudia Tamar, Zorkoltseva, Irina V, Niemeijer, Maartje N, van den Berg, Marten E, Amin, Najaf, Demirkan, Ayşe, van Leeuwen, Elisa, Iglesias, Adriana I, Piñeros-Hernández, Laura B, Restrepo, Carlos M, Kors, Jan A, Kirichenko, Anatoly V, Willemsen, Rob, Oostra, Ben A, Stricker, Bruno H, Uitterlinden, André G, Axenovich, Tatiana I, van Duijn, Cornelia M, Isaacs, Aaron

“…Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses…”
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Gene-based association tests using GWAS summary statistics by Svishcheva, Gulnara R, Belonogova, Nadezhda M, Zorkoltseva, Irina V, Kirichenko, Anatoly V, Axenovich, Tatiana I

“…Abstract Motivation A huge number of genome-wide association studies (GWAS) summary statistics freely available in databases provide a new material for…”
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Multi-Trait Exome-Wide Association Study of Back Pain-Related Phenotypes by Zorkoltseva, Irina V, Elgaeva, Elizaveta E, Belonogova, Nadezhda M, Kirichenko, Anatoliy V, Svishcheva, Gulnara R, Freidin, Maxim B, Williams, Frances M K, Suri, Pradeep, Tsepilov, Yakov A, Axenovich, Tatiana I

“…Back pain (BP) is a major contributor to disability worldwide, with heritability estimated at 40-60%. However, less than half of the heritability is explained…”
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Nonsynonymous Variation in NKPD1 Increases Depressive Symptoms in European Populations by Amin, Najaf, Belonogova, Nadezhda M, Jovanova, Olivera, Brouwer, Rutger W.W, van Rooij, Jeroen G.J, van den Hout, Mirjam C.G.N, Svishcheva, Gulnara R, Kraaij, Robert, Zorkoltseva, Irina V, Kirichenko, Anatoly V, Hofman, Albert, Uitterlinden, André G, van IJcken, Wilfred F.J, Tiemeier, Henning, Axenovich, Tatiana I, van Duijn, Cornelia M

“…Abstract Background Despite high heritability, little success was achieved in mapping genetic determinants of depression-related traits by means of genome-wide…”
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Genetic Architecture of Plasma Adiponectin Overlaps With the Genetics of Metabolic Syndrome-Related Traits by Henneman, Peter, Aulchenko, Yurii S, Frants, Rune R, Zorkoltseva, Irina V, Zillikens, M. Carola, Frolich, Marijke, Oostra, Ben A, van Dijk, Ko Willems, van Duijn, Cornelia M

“…OBJECTIVE: Adiponectin, a hormone secreted by adipose tissue, is of particular interest in metabolic syndrome, because it is inversely correlated with obesity…”
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Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis by Johansson, Åsa, Marroni, Fabio, Hayward, Caroline, Franklin, Christopher S., Kirichenko, Anatoly V., Jonasson, Inger, Hicks, Andrew A., Vitart, Veronique, Isaacs, Aaron, Axenovich, Tatiana, Campbell, Susan, Dunlop, Malcolm G., Floyd, Jamie, Hastie, Nick, Hofman, Albert, Knott, Sara, Kolcic, Ivana, Pichler, Irene, Polasek, Ozren, Rivadeneira, Fernando, Tenesa, Albert, Uitterlinden, André G., Wild, Sarah H., Zorkoltseva, Irina V., Meitinger, Thomas, Wilson, James F., Rudan, Igor, Campbell, Harry, Pattaro, Cristian, Pramstaller, Peter, Oostra, Ben A., Wright, Alan F., van Duijn, Cornelia M., Aulchenko, Yurii S., Gyllensten, Ulf

“…Genes for height have gained interest for decades, but only recently have candidate genes started to be identified. We have performed linkage analysis and…”
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Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene by Johansson, Åsa, Marroni, Fabio, Hayward, Caroline, Franklin, Christopher S, Kirichenko, Anatoly V, Jonasson, Inger, Hicks, Andrew A, Vitart, Veronique, Isaacs, Aaron, Axenovich, Tatiana, Campbell, Susan, Floyd, Jamie, Hastie, Nick, Knott, Sara, Lauc, Gordan, Pichler, Irene

“…As major risk-factors for diabetes and cardiovascular diseases, the genetic contribution to obesity-related traits has been of interest for decades. Recently,…”
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Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes by van Rijn, Marie Josee E, Schut, Anna FC, Aulchenko, Yurii S, Deinum, Jaap, Sayed-Tabatabaei, Fakhredin A, Yazdanpanah, Mojgan, Isaacs, Aaron, Axenovich, Tatiana I, Zorkoltseva, Irina V, Zillikens, M Carola, Pols, Huib AP, Witteman, Jacqueline CM, Oostra, Ben A, van Duijn, Cornelia M

“…OBJECTIVETo study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. METHODSAll…”
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Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions by Amin, Najaf, Hottenga, Jouke-Jan, Hansell, Narelle K, Janssens, A Cecile J W, de Moor, Marleen H M, Madden, Pamela A F, Zorkoltseva, Irina V, Penninx, Brenda W, Terracciano, Antonio, Uda, Manuela, Tanaka, Toshiko, Esko, Tonu, Realo, Anu, Ferrucci, Luigi, Luciano, Michelle, Davies, Gail, Metspalu, Andres, Abecasis, Goncalo R, Deary, Ian J, Raikkonen, Katri, Bierut, Laura J, Costa, Paul T, Saviouk, Viatcheslav, Zhu, Gu, Kirichenko, Anatoly V, Isaacs, Aaron, Aulchenko, Yurii S, Willemsen, Gonneke, Heath, Andrew C, Pergadia, Michele L, Medland, Sarah E, Axenovich, Tatiana I, de Geus, Eco, Montgomery, Grant W, Wright, Margaret J, Oostra, Ben A, Martin, Nicholas G, Boomsma, Dorret I, van Duijn, Cornelia M

“…Personality traits are complex phenotypes related to psychosomatic health. Individually, various gene finding methods have not achieved much success in finding…”
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GADS software for parametric linkage analysis of quantitative traits distributed as a point-mass mixture by Axenovich, Tatiana I., Zorkoltseva, Irina V.

“…[Display omitted] ► We propose a method for the linkage analysis of traits with a spike in the distribution. ► This method was implemented in a software GADS…”
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A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study by Silva, Claudia T, Zorkoltseva, Irina V, Amin, Najaf, Demirkan, Ayşe, van Leeuwen, Elisabeth M, Kors, Jan A, van den Berg, Marten, Stricker, Bruno H, Uitterlinden, André G, Kirichenko, Anatoly V, Witteman, Jacqueline C M, Willemsen, Rob, Oostra, Ben A, Axenovich, Tatiana I, van Duijn, Cornelia M, Isaacs, Aaron

“…Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as…”
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Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2 by Ibrahim-Verbaas, Carla A., Zorkoltseva, Irina V., Amin, Najaf, Schuur, Maaike, Coppus, Antonia M. W., Isaacs, Aaron, Aulchenko, Yurii S., Breteler, Monique M. B., Ikram, M. Arfan, Axenovich, Tatiana I., Verbeek, Marcel M., van Swieten, John C., Oostra, Ben A., van Duijn, Cornelia M.

“…Plasma concentrations of Aβ40 and Aβ42 rise with age and are increased in people with mutations that cause early-onset Alzheimer’s disease (AD). Amyloid beta…”
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Ped_Outlier software for automatic identification of within-family outliers by Zorkoltseva, Irina V., Aulchenko, Yurii S., van Duijn, Cornelia M., Axenovich, Tatiana I.

“…A high-throughput resequencing technology has brought family based studies back into genetic research focus. Within-family outliers (the individuals whose…”
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Breaking loops in large complex pedigrees by Axenovich, Tatiana I, Zorkoltseva, Irina V, Liu, Fan, Kirichenko, Anatoly V, Aulchenko, Yurii S

“…For pedigrees with multiple loops, exact likelihoods could not be computed in an acceptable time frame and thus, approximate methods are used. Some of these…”
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A Genome-Wide Screen for Depression in Two Independent Dutch Populations by Schol-Gelok, Suzanne, Janssens, A. Cecile J.W, Tiemeier, Henning, Liu, Fan, Lopez-Leon, Sandra, Zorkoltseva, Irina V, Axenovich, Tatiana I, van Swieten, John C, Uitterlinden, André G, Hofman, Albert, Aulchenko, Yurii S, Oostra, Ben A, van Duijn, Cornelia M

“…Background Depression has a strong genetic component but candidate gene studies conducted to date have not shown consistent associations. Methods We conducted…”
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Genome-wide linkage screen of cognitive function identifies susceptible chromosomal regions by Schuur, Maaike, Hommel, Danny, Ikram, M. Arfan, Amin, Najaf, Zorkoltseva, Irina V, Kirichenko, Anatoly, de Koning, Inge, Janssens, A. Cecile J.W, Axenovich, Tatiana I, Aulchenko, Yurii S, Hofman, Albert, Breteler, Monique M.B, Oostra, Ben A, van Swieten, John C, van Duijn, Cornelia M

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