Search Results - "ZOLEDZIEWSKA, Magdalena"

The gut microbiota perspective for interventions in MS by Zoledziewska, Magdalena

“…The heritable genetic variation that explains phenotypic differences in a population fluctuates for different autoimmune disorders. Particularly in multiple…”
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Effect of Different Disease-Modifying Therapies on Humoral Response to BNT162b2 Vaccine in Sardinian Multiple Sclerosis Patients by Pitzalis, Maristella, Idda, Maria Laura, Lodde, Valeria, Loizedda, Annalisa, Lobina, Monia, Zoledziewska, Magdalena, Virdis, Francesca, Delogu, Giuseppe, Pirinu, Federica, Marini, Maria Giuseppina, Mingoia, Maura, Frau, Jessica, Lorefice, Lorena, Fronza, Marzia, Carmagnini, Daniele, Carta, Elisa, Orrù, Valeria, Uzzau, Sergio, Solla, Paolo, Loi, Federica, Devoto, Marcella, Steri, Maristella, Fiorillo, Edoardo, Floris, Matteo, Zarbo, Ignazio Roberto, Cocco, Eleonora, Cucca, Francesco

“…Vaccination against COVID-19 is highly recommended to patients affected by multiple sclerosis (MS); however, the impact of MS disease-modifying therapies…”
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Genetic Variation among Pharmacogenes in the Sardinian Population by Idda, Maria Laura, Zoledziewska, Magdalena, Urru, Silvana Anna Maria, McInnes, Gregory, Bilotta, Alice, Nuvoli, Viola, Lodde, Valeria, Orrù, Sandro, Schlessinger, David, Cucca, Francesco, Floris, Matteo

“…Pharmacogenetics (PGx) aims to identify the genetic factors that determine inter-individual differences in response to drug treatment maximizing efficacy while…”
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PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity by Sidore, Carlo, Orrù, Valeria, Cocco, Eleonora, Steri, Maristella, Inshaw, Jamie RJ, Pitzalis, Maristella, Mulas, Antonella, McGurnaghan, Stuart, Frau, Jessica, Porcu, Eleonora, Busonero, Fabio, Dei, Mariano, Lai, Sandra, Sole, Gabriella, Virdis, Francesca, Serra, Valentina, Poddie, Fausto, Delitala, Alessandro, Marongiu, Michele, Deidda, Francesca, Pala, Mauro, Floris, Matteo, Masala, Marco, Onengut-Gumuscu, Suna, Robertson, Catherine C, Leoni, Lidia, Frongia, Annapaola, Ricciardi, Maria Rossella, Chessa, Margherita, Olla, Nazario, Lovicu, Mario, Loizedda, Annalisa, Maschio, Andrea, Mereu, Luisa, Ferrigno, Paola, Curreli, Nicolo, Balaci, Lenuta, Loi, Francesco, Ferreli, Liana AP, Pilia, Maria Grazia, Pani, Antonello, Marrosu, Maria Giovanna, Abecasis, Goncalo R, Rich, Stephen S, Colhoun, Helen, Todd, John A, Schlessinger, David, Fiorillo, Edoardo, Cucca, Francesco, Zoledziewska, Magdalena

“…Background: Defective alleles within the PRF1 gene, encoding the pore-forming protein perforin, in combination with environmental factors, cause familial type…”
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Cross-sectional analysis of the humoral response after SARS-CoV-2 vaccination in Sardinian multiple sclerosis patients, a follow-up study by Idda, Maria Laura, Pitzalis, Maristella, Lodde, Valeria, Loizedda, Annalisa, Frau, Jessica, Lobina, Monia, Zoledziewska, Magdalena, Virdis, Francesca, Delogu, Giuseppe, Marini, Maria Giuseppina, Mingoia, Maura, Masala, Marco, Lorefice, Lorena, Fronza, Marzia, Carmagnini, Daniele, Carta, Elisa, Pilotto, Silvy, Castiglia, Paolo, Chessa, Paola, Uzzau, Sergio, Farina, Gabriele, Solla, Paolo, Steri, Maristella, Devoto, Marcella, Fiorillo, Edoardo, Floris, Matteo, Zarbo, Roberto Ignazio, Cocco, Eleonora, Cucca, Francesco

“…Monitoring immune responses to SARS-CoV-2 vaccination and its clinical efficacy over time in Multiple Sclerosis (MS) patients treated with disease-modifying…”
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Is Epstein Barr virus latency protective against type 1 diabetes? by Zoledziewska, Magdalena

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Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1 by Matesanz, Fuencisla, González-Pérez, Antonio, Lucas, Miguel, Sanna, Serena, Gayán, Javier, Urcelay, Elena, Zara, Ilenia, Pitzalis, Maristella, Cavanillas, María L, Arroyo, Rafael, Zoledziewska, Magdalena, Marrosu, Marisa, Fernández, Oscar, Leyva, Laura, Alcina, Antonio, Fedetz, Maria, Moreno-Rey, Concha, Velasco, Juan, Real, Luis M, Ruiz-Peña, Juan Luis, Cucca, Francesco, Ruiz, Agustín, Izquierdo, Guillermo

“…Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of…”
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Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes by ZOLEDZIEWSKA, Magdalena, PERRA, Chiara, ORRH, Valeria, MOI, Loredana, FRONGIA, Paola, CONGIA, Mauro, BOTTINI, Nunzio, CUCCA, Francesco

“…Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes Magdalena Zoledziewska 1 2 , Chiara Perra 2 † , Valeria Orrù…”
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Propionic Acid Impact on Multiple Sclerosis: Evidence and Challenges by Lorefice, Lorena, Zoledziewska, Magdalena

“…Accumulating evidence suggests that multiple sclerosis (MS) is an environmentally influenced disorder with contributions from life-time exposure to factors…”
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A new mouse model for human immune system-related translational studies by Zoledziewska, Magdalena

“…•Translational studies seek proper animal model reflecting natural immune exposures.•Wild mice microbiota is more comparable to natural human…”
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Complex genetic signatures in immune cells underlie autoimmunity and inform therapy by Orrù, Valeria, Steri, Maristella, Sidore, Carlo, Marongiu, Michele, Serra, Valentina, Olla, Stefania, Sole, Gabriella, Lai, Sandra, Dei, Mariano, Mulas, Antonella, Virdis, Francesca, Piras, Maria Grazia, Lobina, Monia, Marongiu, Mara, Pitzalis, Maristella, Deidda, Francesca, Loizedda, Annalisa, Onano, Stefano, Zoledziewska, Magdalena, Sawcer, Stephen, Devoto, Marcella, Gorospe, Myriam, Abecasis, Gonçalo R., Floris, Matteo, Pala, Mauro, Schlessinger, David, Fiorillo, Edoardo, Cucca, Francesco

“…We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of 3,757 Sardinians. We detected 122 significant ( P  < 1.28 × 10 −11…”
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Intermittent and periodic fasting – Evidence and perspectives in multiple sclerosis by Lorefice, Lorena, Pitzalis, Maristella, Zoledziewska, Magdalena

“…•Both genetics and environment contribute to MS etiopathogenesis.•Diet has been proposed among etiologic factors contributing to MS.•Only small cohort studies…”
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Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia by Pitzalis, Maristella, Zavattari, Patrizia, Murru, Raffaele, Deidda, Elisabetta, Zoledziewska, Magdalena, Murru, Daniela, Moi, Loredana, Motzo, Costantino, Orrù, Valeria, Costa, Gianna, Solla, Elisabetta, Fadda, Elisabetta, Schirru, Lucia, Melis, Maria Cristina, Lai, Marina, Mancosu, Cristina, Tranquilli, Stefania, Cuccu, Stefania, Rolesu, Marcella, Secci, Maria Antonietta, Corongiu, Daniela, Contu, Daniela, Lampis, Rosanna, Nucaro, Annalisa, Pala, Gavino, Pacifico, Adolfo, Maioli, Mario, Frongia, Paola, Chessa, Margherita, Ricciardi, Rossella, Lostia, Stanislao, Marinaro, Anna Maria, Milia, Anna Franca, Landis, Novella, Zedda, Maria Antonietta, Whalen, Michael B, Santoni, Federico, Marrosu, Maria Giovanna, Devoto, Marcella, Cucca, Francesco

“…The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS)…”
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Disease-modifying therapy for multiple sclerosis: Implications for gut microbiota by Pilotto, Silvy, Zoledziewska, Magdalena, Fenu, Giuseppe, Cocco, Eleonora, Lorefice, Lorena

“…•Disease-modifying therapies (DMTs) exert an effect on the gut microenvironment.•Defining the effects of DMTs on microbiota is difficult due to several…”
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Genetic variant within CDK6 regulates immune response to palbociclib treatment by Serra, Valentina, Orrù, Valeria, Steri, Maristella, Fiorillo, Edoardo, Cucca, Francesco, Zoledziewska, Magdalena

“…Everyone carries a set of genetic variants that contribute to regulation of the levels of blood cells, with unknown clinical impact. One of them, rs445 within…”
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Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers by Sidore, Carlo, Busonero, Fabio, Maschio, Andrea, Porcu, Eleonora, Naitza, Silvia, Zoledziewska, Magdalena, Mulas, Antonella, Pistis, Giorgio, Steri, Maristella, Danjou, Fabrice, Kwong, Alan, Ortega del Vecchyo, Vicente Diego, Chiang, Charleston W K, Bragg-Gresham, Jennifer, Pitzalis, Maristella, Nagaraja, Ramaiah, Tarrier, Brendan, Brennan, Christine, Uzzau, Sergio, Fuchsberger, Christian, Atzeni, Rossano, Reinier, Frederic, Berutti, Riccardo, Huang, Jie, Timpson, Nicholas J, Toniolo, Daniela, Gasparini, Paolo, Malerba, Giovanni, Dedoussis, George, Zeggini, Eleftheria, Soranzo, Nicole, Jones, Chris, Lyons, Robert, Angius, Andrea, Kang, Hyun M, Novembre, John, Sanna, Serena, Schlessinger, David, Cucca, Francesco, Abecasis, Gonçalo R

“…Gonçalo Abecasis, Francesco Cucca, David Schlessinger, Serena Sanna and colleagues report ~17.6 million genetic variants from whole-genome sequencing of 2,120…”
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Genomic history of the Sardinian population by Chiang, Charleston W. K., Marcus, Joseph H., Sidore, Carlo, Biddanda, Arjun, Al-Asadi, Hussein, Zoledziewska, Magdalena, Pitzalis, Maristella, Busonero, Fabio, Maschio, Andrea, Pistis, Giorgio, Steri, Maristella, Angius, Andrea, Lohmueller, Kirk E., Abecasis, Goncalo R., Schlessinger, David, Cucca, Francesco, Novembre, John

“…The population of the Mediterranean island of Sardinia has made important contributions to genome-wide association studies of complex disease traits and, based…”
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Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population by Piras, Doloretta, Masala, Marco, Delitala, Alessandro, Urru, Silvana A M, Curreli, Nicolò, Balaci, Lenuta, Ferreli, Liana P, Loi, Francesco, Atzeni, Alice, Cabiddu, Gianfranca, Racugno, Walter, Ventura, Laura, Zoledziewska, Magdalena, Steri, Maristella, Fiorillo, Edoardo, Pilia, Maria G, Schlessinger, David, Cucca, Francesco, Rule, Andrew D, Pani, Antonello

“…Abstract Background The relationship of kidney size to ageing, kidney function and kidney disease risk factors is not fully understood. Methods Ultrasound…”
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Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past by Olivieri, Anna, Sidore, Carlo, Achilli, Alessandro, Angius, Andrea, Posth, Cosimo, Furtwängler, Anja, Brandini, Stefania, Capodiferro, Marco Rosario, Gandini, Francesca, Zoledziewska, Magdalena, Pitzalis, Maristella, Maschio, Andrea, Busonero, Fabio, Lai, Luca, Skeates, Robin, Gradoli, Maria Giuseppina, Beckett, Jessica, Marongiu, Michele, Mazzarello, Vittorio, Marongiu, Patrizia, Rubino, Salvatore, Rito, Teresa, Macaulay, Vincent, Semino, Ornella, Pala, Maria, Abecasis, Gonçalo R, Schlessinger, David, Conde-Sousa, Eduardo, Soares, Pedro, Richards, Martin B, Cucca, Francesco, Torroni, Antonio

“…Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To…”
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Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels by Danjou, Fabrice, Zoledziewska, Magdalena, Sidore, Carlo, Steri, Maristella, Busonero, Fabio, Maschio, Andrea, Mulas, Antonella, Perseu, Lucia, Barella, Susanna, Porcu, Eleonora, Pistis, Giorgio, Pitzalis, Maristella, Pala, Mauro, Menzel, Stephan, Metrustry, Sarah, Spector, Timothy D, Leoni, Lidia, Angius, Andrea, Uda, Manuela, Moi, Paolo, Thein, Swee Lay, Galanello, Renzo, Abecasis, Gonçalo R, Schlessinger, David, Sanna, Serena, Cucca, Francesco

“…Francesco Cucca, Serena Sanna, David Schlessinger, Gonçalo Abecasis and colleagues report genome-wide association analysis results for the levels of A1, A2 and…”
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