Search Results - "ZIOLO, Mark T"

Antiquated ejection fraction: Basic research applications for speckle tracking echocardiography by Sturgill, Sarah L., Shettigar, Vikram, Ziolo, Mark T.

“…For years, ejection fraction has been an essentially ubiquitous measurement for assessing the cardiovascular function of animal models in research labs…”
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Defining the Role of Oxidative Stress in Atrial Fibrillation and Diabetes by ZIOLO, MARK T., MOHLER, PETER J.

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Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models by Ostler, Joseph E, Maurya, Santosh K, Dials, Justin, Roof, Steve R, Devor, Steven T, Ziolo, Mark T, Periasamy, Muthu

“…Type 2 diabetes mellitus is associated with an accelerated muscle loss during aging, decreased muscle function, and increased disability. To better understand…”
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Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation by Curran, Jerry, Tang, Lifei, Roof, Steve R, Velmurugan, Sathya, Millard, Ashley, Shonts, Stephen, Wang, Honglan, Santiago, Demetrio, Ahmad, Usama, Perryman, Matthew, Bers, Donald M, Mohler, Peter J, Ziolo, Mark T, Shannon, Thomas R

“…Spontaneous calcium waves in cardiac myocytes are caused by diastolic sarcoplasmic reticulum release (SR Ca(2+) leak) through ryanodine receptors…”
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Nitric oxide signaling and the regulation of myocardial function by Ziolo, Mark T, Kohr, Mark J, Wang, Honglan

“…Abstract Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of…”
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Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies by Oaks, Joshua J., Santhanam, Ramasamy, Walker, Christopher J., Roof, Steve, Harb, Jason G., Ferenchak, Greg, Eisfeld, Ann-Kathrin, Van Brocklyn, James R., Briesewitz, Roger, Saddoughi, Sahar A., Nagata, Kyosuke, Bittman, Robert, Caligiuri, Michael A., Abdel-Wahab, Omar, Levine, Ross, Arlinghaus, Ralph B., Quintas-Cardama, Alfonso, Goldman, John M., Apperley, Jane, Reid, Alistair, Milojkovic, Dragana, Ziolo, Mark T., Marcucci, Guido, Ogretmen, Besim, Neviani, Paolo, Perrotti, Danilo

“…FTY720 (Fingolimod, Gilenya) is a sphingosine analog used as an immunosuppressant in multiple sclerosis patients. FTY720 is also a potent protein phosphatase…”
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NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model by Peterson, Jennifer M., Wang, David J., Shettigar, Vikram, Roof, Steve R., Canan, Benjamin D., Bakkar, Nadine, Shintaku, Jonathan, Gu, Jin-Mo, Little, Sean C., Ratnam, Nivedita M., Londhe, Priya, Lu, Leina, Gaw, Christopher E., Petrosino, Jennifer M., Liyanarachchi, Sandya, Wang, Huating, Janssen, Paul M. L., Davis, Jonathan P., Ziolo, Mark T., Sharma, Sudarshana M., Guttridge, Denis C.

“…Duchenne muscular dystrophy (DMD) is a neuromuscular disorder causing progressive muscle degeneration. Although cardiomyopathy is a leading mortality cause in…”
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Consequences of PDGFRα + fibroblast reduction in adult murine hearts by Kuwabara, Jill T, Hara, Akitoshi, Bhutada, Sumit, Gojanovich, Greg S, Chen, Jasmine, Hokutan, Kanani, Shettigar, Vikram, Lee, Anson Y, DeAngelo, Lydia P, Heckl, Jack R, Jahansooz, Julia R, Tacdol, Dillon K, Ziolo, Mark T, Apte, Suneel S, Tallquist, Michelle D

“…Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many…”
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Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation by Chung, Jae-Hoon, Biesiadecki, Brandon J, Ziolo, Mark T, Davis, Jonathan P, Janssen, Paul M L

“…Myofilament calcium sensitivity is an often-used indicator of cardiac muscle function, often assessed in disease states such as hypertrophic cardiomyopathy…”
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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease by Shettigar, Vikram, Zhang, Bo, Little, Sean C., Salhi, Hussam E., Hansen, Brian J., Li, Ning, Zhang, Jianchao, Roof, Steve R., Ho, Hsiang-Ting, Brunello, Lucia, Lerch, Jessica K., Weisleder, Noah, Fedorov, Vadim V., Accornero, Federica, Rafael-Fortney, Jill A., Gyorke, Sandor, Janssen, Paul M. L., Biesiadecki, Brandon J., Ziolo, Mark T., Davis, Jonathan P.

“…Treatment for heart disease, the leading cause of death in the world, has progressed little for several decades. Here we develop a protein engineering approach…”
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Exercise-induced 3′-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring by Harris, Johan E., Pinckard, Kelsey M., Wright, Katherine R., Baer, Lisa A., Arts, Peter J., Abay, Eaman, Shettigar, Vikram K., Lehnig, Adam C., Robertson, Bianca, Madaris, Kendra, Canova, Tyler J., Sims, Clark, Goodyear, Laurie J., Andres, Aline, Ziolo, Mark T., Bode, Lars, Stanford, Kristin I.

“…Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease…”
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In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood by Tanwar, Vineeta, Gorr, Matthew W, Velten, Markus, Eichenseer, Clayton M, Long, 3rd, Victor P, Bonilla, Ingrid M, Shettigar, Vikram, Ziolo, Mark T, Davis, Jonathan P, Baine, Stephen H, Carnes, Cynthia A, Wold, Loren E

“…Particulate matter (PM; PM [PM with diameters of <2.5 μm]) exposure during development is strongly associated with adverse cardiovascular outcomes at…”
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Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides by Ho, Hsiang-Ting, Liu, Bin, Snyder, Jedidiah S, Lou, Qing, Brundage, Elizabeth A, Velez-Cortes, Florencia, Wang, Honglan, Ziolo, Mark T, Anderson, Mark E, Sen, Chandan K, Wehrens, Xander H T, Fedorov, Vadim V, Biesiadecki, Brandon J, Hund, Thomas J, Györke, Sándor

“…Recent studies suggest that proarrhythmic effects of cardiac glycosides (CGs) on cardiomyocyte Ca(2+) handling involve generation of reactive oxygen species…”
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Arrhythmogenic Effects of β2-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load by DeSantiago, Jaime, Ai, Xun, Islam, Mohammed, Acuna, Georgia, Ziolo, Mark T, Bers, Donald M, Pogwizd, Steven M

“…Ventricular tachycardia in heart failure (HF) can initiate by nonreentrant mechanisms such as delayed afterdepolarizations. In an arrhythmogenic rabbit model…”
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Micro-dystrophin gene therapy demonstrates long-term cardiac efficacy in a severe Duchenne muscular dystrophy model by Piepho, Arden B., Lowe, Jeovanna, Cumby, Laurel R., Dorn, Lisa E., Lake, Dana M., Rastogi, Neha, Gertzen, Megan D., Sturgill, Sarah L., Odom, Guy L., Ziolo, Mark T., Accornero, Federica, Chamberlain, Jeffrey S., Rafael-Fortney, Jill A.

“…Micro-dystrophin gene replacement therapies for Duchenne muscular dystrophy (DMD) are currently in clinical trials, but have not been thoroughly investigated…”
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CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction-A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat by Roof, Steve R, Ueyama, Yukie, Mazhari, Reza, Hamlin, Robert L, Hartman, J Craig, Ziolo, Mark T, Reardon, John E, Del Rio, Carlos L

“…The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF)…”
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Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration by Salhi, Hussam E, Hassel, Nathan C, Siddiqui, Jalal K, Brundage, Elizabeth A, Ziolo, Mark T, Janssen, Paul M L, Davis, Jonathan P, Biesiadecki, Brandon J

“…Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially…”
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Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise by Roof, Steve R., Tang, Lifei, Ostler, Joseph E., Periasamy, Muthu, Györke, Sandor, Billman, George E., Ziolo, Mark T.

“…Exercise results in beneficial adaptations of the heart that can be directly observed at the ventricular myocyte level. However, the molecular mechanism(s)…”
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Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes by Wang, Honglan, Kohr, Mark J, Traynham, Christopher J, Ziolo, Mark T

“…Abstract Endothelial nitric oxide synthase (NOS3) regulates the functional response to β-adrenergic (β-AR) stimulation via modulation of the L-type Ca2+…”
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A Promoter Polymorphism of the Endothelial Nitric Oxide Synthase Gene is Associated With Reduced mRNA and Protein Expression in Failing Human Myocardium by Doshi, Amit A., MD, Ziolo, Mark T., PhD, Wang, Honglan, PhD, Burke, Emily, RN, BSN, CCTC, Lesinski, Amanda, BS, Binkley, Philip, MD, MPH

“…Abstract Background Alterations of endothelial nitric oxide synthase (eNOS) enzyme activity via eNOS gene polymorphisms have been associated with significant…”
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