Search Results - "ZINK, Deborah L"

Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity by Jayasuriya, Hiranthi, Herath, Kithsiri B., Zhang, Chaowei, Zink, Deborah L., Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Gonzalez, Ignacio, Salazar, Oscar, Pelaez, Fernando, Cummings, Richard, Ha, Sookhee, Wang, Jun, Singh, Sheo B.

“…Two birds with one stone: Platencin (1) is a novel and potent broad‐spectrum Gram‐positive antibiotic. Whereas platensimycin is a selective inhibitor of FabF,…”
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Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy by Singh, Sheo B, Jayasuriya, Hiranthi, Ondeyka, John G, Herath, Kithsiri B, Zhang, Chaowei, Zink, Deborah L, Tsou, Nancy N, Ball, Richard G, Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Pelaez, Fernando, Young, Katherine, Wang, Jun

“…Fatty acids are essential for survival of bacteria and are synthesized by a series of enzymes including the elongation enzymes, β-ketoacyl acyl carrier protein…”
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Platensimycin and Platencin Congeners from Streptomyces platensis by Zhang, Chaowei, Ondeyka, John, Herath, Kithsiri, Jayasuriya, Hiranthi, Guan, Ziqiang, Zink, Deborah L, Dietrich, Lisa, Burgess, Bruce, Ha, Sookhee N, Wang, Jun, Singh, Sheo B

“…Platensimycin (1a) and platencin (2) are inhibitors of FabF and FabF/H bacterial fatty acid synthase. The discovery of natural congeners is an approach that…”
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Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin by Ondeyka, John G, Smith, Scott K, Zink, Deborah L, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Garlisi, Charles, Mcguinness, Debra, Smith, Elizabeth, Qiu, Hongchen, Gill, Charles J, Donald, Robert GK, Phillips, John W, Goetz, Michael A, Singh, Sheo B

“…The ever-increasing bacterial resistance to clinical antibiotics is making many drugs ineffective and creating significant treatment gaps. This can be only…”
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Isolation, Structure Elucidation, and Biological Activity of Altersolanol P Using Staphylococcus aureus Fitness Test Based Genome-Wide Screening by Ondeyka, John, Buevich, Alexei V, Williamson, R. Thomas, Zink, Deborah L, Polishook, Jon D, Occi, James, Vicente, Francisca, Basilio, Angela, Bills, Gerald F, Donald, Robert G. K, Phillips, John W, Goetz, Michael A, Singh, Sheo B

“…Bacteria continue to evade existing antibiotics by acquiring resistance by various mechanisms, leading to loss of antibiotic effectiveness. To avoid an…”
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Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (Capnodium sp.) by Herath, Kithsiri, Jayasuriya, Hiranthi, Zink, Deborah L, Sigmund, Jan, Vicente, Francisca, de la Cruz, Mercedes, Basilio, Angela, Bills, Gerald F, Polishook, Jon D, Donald, Robert, Phillips, John, Goetz, Michael, Singh, Sheo B

“…Drug-resistant bacteria continue to make many existing antibiotic classes ineffective. In order to avoid a future epidemic from drug-resistant bacterial…”
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Isolation, Structure, and Antibacterial Activities of Lucensimycins D−G, Discovered from Streptomyces lucensis MA7349 Using an Antisense Strategy by Singh, Sheo B, Zink, Deborah L, Dorso, Karen, Motyl, Mary, Salazar, Oscar, Basilio, Angela, Vicente, Francisca, Byrne, Kevin M, Ha, Sookhee, Genilloud, Olga

“…Bacterial resistance to existing antibiotics continues to grow, necessitating the discovery of new compounds of this type. Antisense-based whole-cell…”
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Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening by Singh, Sheo B, Zhang, Chaowei, Zink, Deborah L, Herath, Kithsiri, Ondeyka, John, Masurekar, Prakash, Jayasuriya, Hiranthi, Goetz, Michael A, Tormo, Jose Rubén, Vicente, Francisca, Martín, Jesús, González, Ignacio, Genilloud, Olga

“…Natural products have been major sources of antibacterial agents and remain very promising. Frequent rediscoveries of known compounds hampers progress of new…”
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Anthelmintic constituents of Clonostachys candelabrum by Ayers, Sloan, Zink, Deborah L, Mohn, Kenneth, Powell, Joanne S, Brown, Christine M, Bills, Gerald, Grund, Alan, Thompson, Donald, Singh, Sheo B

“…Five diastereomeric polyketide glycosides, roselipins 3A-3E ( 1 – 5 ), have been isolated from the acetone extract of Clonostachys candelabrum on the basis of…”
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Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis by Singh, Sheo B, Ondeyka, John G, Herath, Kithsiri B, Zhang, Chaowei, Jayasuriya, Hiranthi, Zink, Deborah L, Parthasarathy, Gopalakrishnan, Becker, Joseph W, Wang, Jun, Soisson, Stephen M

“…Natural products continue to serve as one of the best sources for discovery of antibacterial agents as exemplified by the recent discoveries of platensimycin…”
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Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4 by Zhang, Chaowei, Ondeyka, John G, Zink, Deborah L, Basilio, Angela, Vicente, Francisca, Salazar, Oscar, Genilloud, Olga, Dorso, Karen, Motyl, Mary, Byrne, Kevin, Singh, Sheo B

“…Protein synthesis inhibition is a highly successful target for developing clinically effective and safe antibiotics. There are several targets within the…”
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Discovery and antibacterial activity of lucensimycin C from Streptomyces lucensis by Singh, Sheo B., Zink, Deborah L., Herath, Kithsiri B., Salazar, Oscar, Genilloud, Olga

“…Isolation, structure elucidation, antibiotic activity, and biogenesis have been described. Protein synthesis is one of the key and validated antibacterial…”
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Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites by SINGH, Sheo B, JAYASURIYA, Hiranthi, FELOCK, Peter J, HAZUDA, Daria J, DEWEY, Raymond, POLISHOOK, Jon D, DOMBROWSKI, Anne W, ZINK, Deborah L, ZIQIANG GUAN, COLLADO, Javier, PLATAS, Gonzalo, PELAEZ, Fernando

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug strategies for anti-retroviral therapy,…”
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Discovery of Lucensimycins A and B from Streptomyces lucensis MA7349 Using an Antisense Strategy by Singh, Sheo B, Zink, Deborah L, Huber, Joanne, Genilloud, Olga, Salazar, Oscar, Diez, M. Teresa, Basilio, Angela, Vicente, Francisca, Byrne, Kevin M

“…Inhibition of protein synthesis is one of the validated and highly successful targets for inhibition of bacterial growth; this mechanism is a target of a large…”
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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9 by Petrilli, Whitney L, Adam, Gregory C, Erdmann, Roman S, Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P, Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M, Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P, Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M, Strack, Alison M, Youm, Hyewon, Zhao, Kake, Zink, Deborah L, Zokian, Hratch, Addona, George H, Akinsanya, Karen, Tata, James R, Xiong, Yusheng, Imbriglio, Jason E

“…Proprotein convertase substilisin-like/kexin type 9 (PCSK9) is a serine protease involved in a protein-protein interaction with the low-density lipoprotein…”
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Coelomycin, a highly substituted 2,6-dioxo-pyrazine fungal metabolite antibacterial agent discovered by Staphylococcus aureus fitness test profiling by Goetz, Michael A, Zhang, Chaowei, Zink, Deborah L, Arocho, Marta, Vicente, Francisca, Bills, Gerald F, Polishook, Jon, Dorso, Karen, Onishi, Russell, Gill, Charles, Hickey, Emily, Lee, Suzy, Ball, Richard, Skwish, Stephen, Donald, Robert G K, Phillips, John W, Singh, Sheo B

“…Bacterial resistance to antibiotics, particularly to multiple antibiotics, is becoming a cause for significant concern. The only really viable course of action…”
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Isolation and structure elucidation of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa by Jayasuriya, Hiranthi, Herath, Kithsiri, Ondeyka, John G, Zhang, Chaowei, Zink, Deborah L, Brower, Mark, Gailliot, Francis P, Greene, Joyce, Birdsall, Gwyneth, Venugopal, Jayashree, Ushio, Misti, Burgess, Bruce, Russotti, Greg, Walker, Andre, Hesse, Michelle, Seeley, Anna, Junker, Beth, Connors, Neal, Salazar, Oscar, Genilloud, Olga, Liu, Kun, Masurekar, Prakash, Barrett, John F, Singh, Sheo B

“…Thiazolyl peptides are a class of rigid macrocyclic compounds richly populated with thiazole rings. They are highly potent antibiotics but none have been…”
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Anthelmintic Macrolactams from Nonomuraea turkmeniaca MA7381 by Ayers, Sloan, Zink, Deborah L, Powell, Joanne Staats, Brown, Christine M, Grund, Alan, Genilloud, Olga, Salazar, Oscar, Thompson, Donald, Singh, Sheo B

“…A new macrolactam, fluvirucin B 0 ( 1 ), and two known macrolactams, Sch 38516/fluvirucin B 1 ( 2 ) and Sch 39185/fluvirucin B 3 ( 3 ), have been isolated from…”
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Nodulisporic Acids D−F:  Structure, Biological Activities, and Biogenetic Relationships by Singh, Sheo B, Ondeyka, John G, Jayasuriya, Hiranthi, Zink, Deborah L, Ha, Sookhee N, Dahl-Roshak, Arlene, Greene, Joyce, Kim, Jennifer A, Smith, McHardy M, Shoop, Wesley, Tkacz, Jan S

“…Nodulisporic acids D, E, and F (7−12) are the newest members of a family of nontremorogenic indole-diterpenoids that are potent, orally bioavailable, antiflea…”
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Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Xanthoviridicatin E and F, Two Novel Fungal Metabolites Produced by Penicillium chrysogenum by Singh, Sheo B., Zink, Deborah L., Guan, Ziqiang, Collado, Javier, Pelaez, Fernando, Felock, Peter J., Hazuda, Daria J.

“…HIV‐1 Integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug targets for anti‐retroviral therapy with…”
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