Search Results - "ZINGARELLI, B"

mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells by Guo, F, Li, J, Du, W, Zhang, S, O'Connor, M, Thomas, G, Kozma, S, Zingarelli, B, Pang, Q, Zheng, Y

“…Hematopoietic stem/progenitor cells (HSPCs) function to give rise to mature blood cells. Effective DNA damage response (DDR) and maintenance of genomic…”
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Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite by Szabó, C, Cuzzocrea, S, Zingarelli, B, O'Connor, M, Salzman, A L

“…DNA single strand breakage and activation of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) contribute to peroxynitrite-induced cellular injury. We…”
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Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase by Zingarelli, B, Szabó, C, Salzman, A L

“…BACKGROUND Oxidative and nitrosative stress have been implicated in the pathogenesis of inflammatory bowel diseases. AIMS To study the role of nitric oxide…”
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DNA Strand Breakage, Activation of Poly(ADP-Ribose) Synthetase, and Cellular Energy Depletion are Involved in the Cytotoxicity in Macrophages and Smooth Muscle Cells Exposed to Peroxynitrite by Szabó, Csaba, Zingarelli, Basilia, O'Connor, Michael, Salzman, Andrew L.

“…The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been…”
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Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase by ZINGARELLI, B, CUZZOCREA, S, ZSENGELLER, Z, SALZMAN, A. L, SZABO, C

“…Peroxynitrite and hydroxyl radical, reactive oxidants produced during reperfusion, are potent triggers of DNA single strand breakage. DNA injury triggers the…”
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Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis by Zingarelli, Basilia, Szabó, Csaba, Salzman, Andrew L.

“…Background & Aims: Inflammatory bowel disease is characterized by oxidative and nitrosative stress, leukocyte infiltration, and up-regulation of intercellular…”
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Absence of endogenous interleukin 10 enhances early stress response during post-ischaemic injury in mice intestine by Zingarelli, B, Yang, Z, Hake, P W, Denenberg, A, Wong, H R

“…BACKGROUND Interleukin 10 (IL-10) exerts a wide spectrum of regulatory activities in immune and inflammatory responses. AIMS The aim of this study was to…”
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Peroxynitrite‐mediated DNA strand breakage activates poly (ADP‐ribose) synthetase and causes cellular energy depletion in carrageenan‐induced pleurisy by Cuzzocrea, S, Caputi, A P, Zingarelli, B

“…The aim of the present study was to investigate the role of poly (ADP‐ribose) synthetase in acute local inflammation (carrageenan‐induced pleurisy), where…”
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Isoproterenol regulates tumour necrosis factor, interleukin‐10, interleukin‐6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia by SZABÓ, C., HASKÓ, G., ZINGARELLI, B., NÉMETH, Z. H., SALZMAN, A. L., KVETAN, V., MCCARTHY PASTORES, S., VIZI, E. S.

“…Pro‐inflammatory cytokines, such as tumour necrosis factor (TNF) and free radicals, such as nitric oxide (NO), are mediators of endotoxaemia. Catecholamines…”
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Nuclear factor-κB by Zingarelli, Basilia

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Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform by Southan, Garry J., Zingarelli, Basilia, O'Connor, Michael, Salzman, Andrew L., Szabó, Csaba

“…1 The generation of nitric oxide (NO) from L‐arginine by NO synthases (NOS) can be inhibited by guanidines, amidines and S‐alkylisothioureas. Unlike most…”
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Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration by Cuzzocrea, S, Tailor, A, Zingarelli, B, Salzman, AL, Flower, RJ, Szabo, C, Perretti, M

“…Splanchnic artery occlusion and reperfusion (SAO/R) shock was induced in rats by clamping both the superior mesenteric artery and the celiac trunk for 45 min,…”
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Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats by Squadrito, F, Calapai, G, Altavilla, D, Cucinotta, D, Zingarelli, B, Campo, G M, Arcoraci, V, Sautebin, L, Mazzaglia, G, Caputi, A P

“…We studied nitric oxide (NO) synthase activity and serotonin content in the diencephalon of 24 hr food deprived rats. NO synthase activity was significantly…”
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Role of tumor necrosis factor-alpha in acute hypovolemic hemorrhagic shock in rats by Zingarelli, B, Squadrito, F, Altavilla, D, Calapai, G, Di Rosa, M, Caputi, A P

“…Hemorrhagic shock was induced in male anesthetized rats by intermittently withdrawing blood from an iliac catheter until mean arterial blood pressure (MAP)…”
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Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform by Szabó, Csaba, Bryk, Ruslana, Zingarelli, Basilia, Southan, Garry J., Gahman, Timothy C., Bhat, Venkat, Salzman, Andrew L., Wolff, Donald J.

“…1 . Guanidines, amidines, S‐alkylisothioureas, and recently, mercaptoalkylguanidines have been described as inhibitors of the generation of nitric oxide (NO)…”
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Evidence that nitric oxide modulates drinking behaviour by Calapai, G, Squadrito, F, Altavilla, D, Zingarelli, B, Campo, G M, Cilia, M, Caputi, A P

“…The involvement of the L-arginine-nitric oxide (NO) pathway in brain, in the regulation of drinking behaviour, has been evaluated by injecting L-arginine and N…”
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HYPOTHERMIA MODULATES BRAIN INJURY IN BACTERIAL MENINGITIS by Irazuzta, Jose, Zingarelli, B, Milam, K, Kiefaber, M, Kamdar, T

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Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase by Zingarelli, B, Virág, L, Szabó, A, Cuzzocrea, S, Salzman, A L, Szabó, C

“…In the present study, we evaluated the impact of the lack of the gene for inducible nitric oxide synthase (iNOS) on oxidation, tyrosine nitration and…”
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Peroxisome proliferator-activated receptor-γ is a new therapeutic target in sepsis and inflammation by ZINGARELLI, Basilia, COOK, James A

“…Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear receptor superfamily and a ligand-activated transcription factor with…”
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Evidence for a role of nitric oxide in hypovolemic hemorrhagic shock by Zingarelli, B, Squadrito, F, Altavilla, D, Calapai, G, Campo, G M, Calò, M, Saitta, A, Caputi, A P

“…Hypovolemic hemorrhagic shock was induced in rats by intermittently withdrawing blood from an iliac catheter for 20 min until mean arterial blood pressure…”
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