Search Results - "ZIMNIAK, P"

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice by Singh, Sharda P., Niemczyk, Maciej, Saini, Deepti, Sadovov, Vladimir, Zimniak, Ludwika, Zimniak, Piotr

“…The lipid peroxidation product 4-hydroxynonenal (4-HNE) forms as a consequence of oxidative stress. By electrophilic attack on biological macromolecules, 4-HNE…”
Get full text

Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal by Ayyadevara, Srinivas, Dandapat, Abhijit, Singh, Sharda P., Siegel, Eric R., Shmookler Reis, Robert J., Zimniak, Ludwika, Zimniak, Piotr

“…The lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) forms as a consequence of oxidative stress, and acts as a signaling molecule or, at…”
Get full text

Novel Function of Human RLIP76:  ATP-Dependent Transport of Glutathione Conjugates and Doxorubicin by Awasthi, Sanjay, Cheng, Jizhong, Singhal, Sharad S, Saini, Manjit K, Pandya, Utpal, Pikula, Slawomir, Bandorowicz-Pikula, Joanna, Singh, Shivendra V, Zimniak, Piotr, Awasthi, Yogesh C

“…Active transport of conjugated and unconjugated electrophiles out of cells is essential for cellular homeostasis. We have previously identified in human…”
Get full text

Functional Reassembly of ATP-Dependent Xenobiotic Transport by the N- and C-Terminal Domains of RLIP76 and Identification of ATP Binding Sequences by Awasthi, Sanjay, Cheng, Ji-Zhong, Singhal, Sharad S, Pandya, Utpal, Sharma, Rajendra, Singh, Shivendra V, Zimniak, Piotr, Awasthi, Yogesh C

“…We have recently shown that RLIP76, a Ral-binding, GTPase-activating protein, is an ATP-dependent transporter of doxorubicin (DOX) as well as glutathione…”
Get full text

Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7) by ZIMNIAK, P, SINGHAL, S. S, SRIVASTAVA, S. K, SANJAY AWASTHI, RASHMI SHARMA, HAYDEN, J. B, AWASTHI, Y. C

“…We have previously isolated a cDNA clone for a unique mouse lung glutathione S-transferase, mGSTA4-4 (GST 5.7) (Zimniak, P., Eckles, M. A., Saxena, M., and…”
Get full text

Reduction of MTT by glutathione S-transferase by York, J L, Maddox, L C, Zimniak, P, McHugh, T E, Grant, D F

“…The reduction of the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to a blue formazan product is widely used for…”
Get full text

Human liver steroid sulphotransferase sulphates bile acids by RADOMINSKA, A, COMER, K. A, ZIMNIAK, P, FALANY, J, ISCAN, M, FALANY, C. N

“…The sulphation of bile acids is an important pathway for the detoxification and elimination of bile acids during cholestatic liver disease. A…”
Get full text

Several closely related glutathione S-transferase isozymes catalyzing conjugation of 4-hydroxynonenal are differentially expressed in human tissues by Singhal, S S, Zimniak, P, Awasthi, S, Piper, J T, He, N G, Teng, J I, Petersen, D R, Awasthi, Y C

“…A human acidic glutathione S-transferase, hGST 5.8, was isolated from heart, pancreas, and brain by a procedure involving immunoadsorption chromatography on…”
Get more information

Organic anion-transporting ATPase of rat liver. I. Purification, photoaffinity labeling, and regulation by phosphorylation by Pikula, S, Hayden, J B, Awasthi, S, Awasthi, Y C, Zimniak, P

“…An ATP-dependent transport system specific for non-bile acid organic anions such as S-(2,4-dinitrophenyl)-glutathione is present in the canalicular plasma…”
Get full text

Organic anion-transporting ATPase of rat liver. II. Functional reconstitution of active transport and regulation by phosphorylation by Pikula, S, Hayden, J B, Awasthi, S, Awasthi, Y C, Zimniak, P

“…We have previously purified to homogeneity from rat liver plasma membranes a 90-kDa glycoprotein with S-(2,4-dinitrophenyl)glutathione-stimulated ATPase…”
Get full text

Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia by Kuipers, F, Radominska, A, Zimniak, P, Little, J M, Havinga, R, Vonk, R J, Lester, R

“…Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY…”
Get full text

Novel human ocular glutathione S-transferases with high activity toward 4-hydroxynonenal by Singhal, SS, Awasthi, S, Srivastava, SK, Zimniak, P, Ansari, NH, Awasthi, YC

“…To study the distribution and expression of glutathione S-transferase isozymes involved in detoxification of endogenously generated toxic products of lipid…”
Get full text

Glucuronidation of 6α-hydroxy bile acids by human liver microsomes by RADOMINSKA-PYREK, A, ZIMNIAK, P, IRSHAID, Y. M, LESTER, R, TEPHLY, T. R, ST PYREK, J

“…The glucuronidation of 6-hydroxylated bile acids by human liver microsomes has been studied in vitro; for comparison, several major bile acids lacking a…”
Get full text

Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class by Sawicki, Rafał, Singh, Sharda P, Mondal, Ashis K, Benes, Helen, Zimniak, Piotr

“…From the fruitfly, Drosophila melanogaster, ten members of the cluster of Delta-class glutathione S-transferases (GSTs; formerly denoted as Class I GSTs) and…”
Get full text

Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells by CHENG, Kunrong, ZIMNIAK, Piotr, RAUFMAN, Jean-Pierre

“…Some human colon cancer cell lines (e.g., H508 cells) express M3 subtype muscarinic receptors that are activated by cholinergic agonists. The objective of the…”
Get full text

Synthesis and characterization of 5-azido-UDP-glucuronic acid. A new photoaffinity probe for UDP-glucuronic acid-utilizing proteins by DRAKE, R. R, ZIMNIAK, P, HALEY, B. E, LESTER, R, ELBEIN, A. D, RADOMINSKA, A

“…A new active site-directed photoaffinity analogue, [beta-32P]5-azido-UDP-glucuronic acid (UDP-GlcA), was enzymatically synthesized from [beta-32P]5-N3UDP-Glc…”
Get full text

Electrogenicity of Ca2+ transport catalyzed by the Ca2+-ATPase from sarcoplasmic reticulum by Zimniak, P, Racker, E

Get full text

Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes by Zimniak, P, Holsztynska, E J, Lester, R, Waxman, D J, Radominska, A

“…The hydroxylation of lithocholic acid (3 alpha-hydroxy-5 beta-cholanoic acid) by adult male Sprague-Dawley rat liver microsomes supplemented with NADPH was…”
Get full text

Glucuronides of monohydroxylated bile acids: specificity of microsomal glucuronyltransferase for the glucuronidation site, C-3 configuration, and side chain length by Radomińska-Pyrek, A, Zimniak, P, Chari, M, Golunski, E, Lester, R, St Pyrek, J

“…The ability of rat liver microsomes to catalyze UDP-glucuronic acid-dependent glucuronidation of monohydroxy-bile acids was examined. The following bile acids…”
Get full text

Formation of three types of glucuronides of 6-hydroxy bile acids by rat liver microsomes by Zimniak, P, Radominska, A, Zimniak, M, Lester, R

“…The glucuronidation of 6-hydroxylated bile acids by rat liver microsomes was studied in vitro; for comparison, several major bile acids lacking a hydroxyl…”
Get full text