Search Results - "ZIMA, V"

Redox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases by Nikolaienko, Roman, Bovo, Elisa, Zima, Aleksey V

“…Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because contraction is mainly driven by Ca released from the sarcoplasmic…”
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Cysteines 1078 and 2991 cross-linking plays a critical role in redox regulation of cardiac ryanodine receptor (RyR) by Nikolaienko, Roman, Bovo, Elisa, Kahn, Daniel, Gracia, Ryan, Jamrozik, Thomas, Zima, Aleksey V.

“…The most common cardiac pathologies, such as myocardial infarction and heart failure, are associated with oxidative stress. Oxidation of the cardiac ryanodine…”
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Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump by Bovo, Elisa, Nikolaienko, Roman, Kahn, Daniel, Cho, Ellen, Robia, Seth L., Zima, Aleksey V.

“…•Presenilin 1 directly interacts with SERCA2a.•Direct measurement of ER Ca2+ shows that PS1 directly regulates SERCA2a function.•PS1 regulates SERCA2a with a…”
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Ca handling during excitation–contraction coupling in heart failure by Zima, Aleksey V., Bovo, Elisa, Mazurek, Stefan R., Rochira, Jennifer A., Li, Weiyan, Terentyev, Dmitry

“…In the heart, coupling between excitation of the surface membrane and activation of contractile apparatus is mediated by Ca released from the sarcoplasmic…”
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Expression level of cardiac ryanodine receptors dictates properties of Ca2+-induced Ca2+ release by Nikolaienko, Roman, Bovo, Elisa, Zima, Aleksey V.

“…The type 2 ryanodine receptor (RyR2) is the major Ca2+ release channel required for Ca2+-induced Ca2+ release (CICR) and cardiac excitation-contraction…”
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Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart by Zima, Aleksey V, Mazurek, Stefan R

“…Type 2 ryanodine receptor (RyR2) serves as the major intracellular Ca release channel that drives heart contraction. RyR2 is activated by cytosolic Ca via the…”
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Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells by Bovo, Elisa, Nikolaienko, Roman, Cleary, Sean R., Seflova, Jaroslava, Kahn, Daniel, Robia, Seth L., Zima, Aleksey V.

“…The type 2a sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA2a) plays a key role in intracellular Ca2+ regulation in the heart. We have previously shown…”
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Redistribution of SERCA calcium pump conformers during intracellular calcium signaling by Raguimova, Olga N., Smolin, Nikolai, Bovo, Elisa, Bhayani, Siddharth, Autry, Joseph M., Zima, Aleksey V., Robia, Seth L.

“…The conformational changes of a calcium transport ATPase were investigated with molecular dynamics (MD) simulations as well as fluorescence resonance energy…”
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Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA by Fisher, M'Lynn E, Bovo, Elisa, Aguayo-Ortiz, Rodrigo, Cho, Ellen E, Pribadi, Marsha P, Dalton, Michael P, Rathod, Nishadh, Lemieux, M Joanne, Espinoza-Fonseca, L Michel, Robia, Seth L, Zima, Aleksey V, Young, Howard S

“…The sarco-plasmic reticulum calcium pump (SERCA) plays a critical role in the contraction-relaxation cycle of muscle. In cardiac muscle, SERCA is regulated by…”
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Endothelin-1–Induced Arrhythmogenic Ca2+ Signaling Is Abolished in Atrial Myocytes of Inositol-1,4,5-Trisphosphate(IP3)–Receptor Type 2–Deficient Mice by Li, Xiaodong, Zima, Aleksey V, Sheikh, Farah, Blatter, Lothar A, Chen, Ju

“…Recent studies have suggested that inositol-1,4,5-trisphosphate-receptor (IP3R)–mediated Ca release plays an important role in the modulation of…”
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The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function by Johnson, Christopher N., Pattanayek, Rekha, Potet, Franck, Rebbeck, Robyn T., Blackwell, Daniel J., Nikolaienko, Roman, Sequeira, Vasco, Le Meur, Remy, Radwański, Przemysław B., Davis, Jonathan P., Zima, Aleksey V., Cornea, Razvan L., Damo, Steven M., Györke, Sandor, George, Alfred L., Knollmann, Björn C.

“…[Display omitted] •Ca2+ /Calmodulin (CaM) binds the CaM dependent kinase II inhibitor (CaMKII) KN93.•KN93 modifies NaV1.5 and RyR2 function independent of…”
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Formation of Layered Proton-Conducting Zirconium and Titanium Organophosphonates by Topotactic Reaction: Physicochemical Properties, Proton Dynamics, and Atomic-Resolution Structure by Melánová, K, Brus, J, Zima, V, Beneš, L, Svoboda, J, Kobera, L, Kutálek, P

“…A series of new zirconium and titanium phosphates-organophosphonates, in which the organophosphonate moiety is functionalized with a sulfo group, was prepared…”
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Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes by Kockskämper, Jens, Zima, Aleksey V, Roderick, H. Llewelyn, Pieske, Burkert, Blatter, Lothar A, Bootman, Martin D

“…Abstract Inositol 1,4,5-trisphosphate (IP3 ) is a ubiquitous intracellular messenger regulating diverse functions in almost all mammalian cell types. It is…”
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Dynamic Calcium Movement Inside Cardiac Sarcoplasmic Reticulum During Release by Picht, Eckard, Zima, Aleksey V, Shannon, Thomas R, Duncan, Alexis M, Blatter, Lothar A, Bers, Donald M

“…RATIONALE:Intra–sarcoplasmic reticulum (SR) free [Ca] ([Ca]SR) provides the driving force for SR Ca release and is a key regulator of SR Ca release channel…”
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R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes by Bovo, Elisa, Martin, Jody L, Tyryfter, Jollyn, de Tombe, Pieter P, Zima, Aleksey V

“…In cardiomyocytes, [Ca] within the sarcoplasmic reticulum (SR; [Ca]SR) partially determines the amplitude of cytosolic Ca transient that, in turn, governs…”
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Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure by Domeier, Timothy L., Blatter, Lothar A., Zima, Aleksey V.

“…Many physiological processes and pharmacological agents modulate the ryanodine receptor (RyR), the primary sarcoplasmic reticulum (SR) Ca 2+ release channel in…”
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The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor by Nikolaienko, Roman, Bovo, Elisa, Rebbeck, Robyn T., Kahn, Daniel, Thomas, David D., Cornea, Razvan L., Zima, Aleksey V.

“…The type 2 ryanodine receptor (RyR2) plays a key role in the cardiac intracellular calcium (Ca2+) regulation. We have previously shown that oxidative stress…”
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Single Ryanodine Receptor Channel Basis of Caffeine's Action on Ca²⁺ Sparks by Porta, Maura, Zima, Aleksey V, Nani, Alma, Diaz-Sylvester, Paula L, Copello, Julio A, Ramos-Franco, Josefina, Blatter, Lothar A, Fill, Michael

“…Caffeine (1, 3, 7-trimethylxanthine) is a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca²⁺ release channel. It is also a…”
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IP3-dependent nuclear Ca2+ signalling in the mammalian heart by Zima, Aleksey V., Bare, Dan J., Mignery, Gregory A., Blatter, Lothar A.

“…In cardiac myocytes the type-2 inositol 1,4,5-trisphosphate receptor (IP 3 R2) is the predominant isoform expressed. The IP 3 R2 channel is localized to the SR…”
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Nest site selection and reproductive parameters of the threatened Atlantic Royal Flycatcher (Onychorhynchus swainsoni) and their significance for conservation by Perrella, Daniel F., Zima, Paulo V. Q., Francisco, Mercival R.

“…Abstract Background Patterns of rarity can be explained by reproductive rates, levels of endemism, and habitat specificity, and knowledge on these parameters…”
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