Search Results - "ZILBERTER, Misha"

Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models by Malkov, Anton, Ivanov, Anton I., Latyshkova, Alexandra, Bregestovski, Piotr, Zilberter, Misha, Zilberter, Yuri

“…Objective Despite decades of epilepsy research, 30% of focal epilepsies remain resistant to antiseizure drugs, with effective drug development impeded by lack…”
Get full text

Seizure-induced reduction in glucose utilization promotes brain hypometabolism during epileptogenesis by Malkov, Anton, Ivanov, Anton I., Buldakova, Svetlana, Waseem, Tatsiana, Popova, Irina, Zilberter, Misha, Zilberter, Yuri

“…Brain glucose hypometabolism is an early symptom of acquired epilepsy, its causative mechanism yet unclear. We suggest that a bidirectional positive feedback…”
Get full text

Glycolysis and Oxidative Phosphorylation in Neurons and Astrocytes during Network Activity in Hippocampal Slices by Ivanov, Anton I, Malkov, Anton E, Waseem, Tatsiana, Mukhtarov, Marat, Buldakova, Svetlana, Gubkina, Olena, Zilberter, Misha, Zilberter, Yuri

“…Network activation triggers a significant energy metabolism increase in both neurons and astrocytes. Questions of the primary neuronal energy substrate (e.g.,…”
Get full text

In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons by Najm, Ramsey, Zalocusky, Kelly A., Zilberter, Misha, Yoon, Seo Yeon, Hao, Yanxia, Koutsodendris, Nicole, Nelson, Maxine, Rao, Antara, Taubes, Alice, Jones, Emily A., Huang, Yadong

“…Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in…”
Get full text

Neurons require glucose uptake and glycolysis in vivo by Li, Huihui, Guglielmetti, Caroline, Sei, Yoshitaka J., Zilberter, Misha, Le Page, Lydia M., Shields, Lauren, Yang, Joyce, Nguyen, Kevin, Tiret, Brice, Gao, Xiao, Bennett, Neal, Lo, Iris, Dayton, Talya L., Kampmann, Martin, Huang, Yadong, Rathmell, Jeffrey C., Vander Heiden, Matthew, Chaumeil, Myriam M., Nakamura, Ken

“…Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics,…”
Get full text

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice by Malkov, Anton, Popova, Irina, Ivanov, Anton, Jang, Sung-Soo, Yoon, Seo Yeon, Osypov, Alexander, Huang, Yadong, Zilberter, Yuri, Zilberter, Misha

“…A predominant trigger and driver of sporadic Alzheimer’s disease (AD) is the synergy of brain oxidative stress and glucose hypometabolism starting at early…”
Get full text

Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4 -related Alzheimer's disease by Taubes, Alice, Nova, Phil, Zalocusky, Kelly A, Kosti, Idit, Bicak, Mesude, Zilberter, Misha Y, Hao, Yanxia, Yoon, Seo Yeon, Oskotsky, Tomiko, Pineda, Silvia, Chen, Bin, Jones, Emily A Aery, Choudhary, Krishna, Grone, Brian, Balestra, Maureen E, Chaudhry, Fayzan, Paranjpe, Ishan, De Freitas, Jessica, Koutsodendris, Nicole, Chen, Nuo, Wang, Celine, Chang, William, An, Alice, Glicksberg, Benjamin S, Sirota, Marina, Huang, Yadong

“…The evident genetic, pathological, and clinical heterogeneity of Alzheimer's disease (AD) poses challenges for traditional drug development. We conducted a…”
Get full text

Secretagogin is a Ca²⁺-binding protein specifying subpopulations of telencephalic neurons by Mulder, Jan, Zilberter, Misha, Spence, Lauren, Tortoriello, Giuseppe, Uhlén, Mathias, Yanagawa, Yuchio, Aujard, Fabienne, Hökfelt, Tomas, Harkany, Tibor

“…The Ca²⁺-binding proteins (CBPs) parvalbumin, calbindin, and calretinin are phenotypic markers of terminally differentiated neurons in the adult brain…”
Get full text

The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction by Zilberter, Yuri, Zilberter, Misha

“…Hypometabolism, characterized by decreased brain glucose consumption, is a common feature of many neurodegenerative diseases. Initial hypometabolic brain…”
Get full text

Author Correction: Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease by Taubes, Alice, Nova, Phil, Zalocusky, Kelly A, Kosti, Idit, Bicak, Mesude, Zilberter, Misha Y, Hao, Yanxia, Yoon, Seo Yeon, Oskotsky, Tomiko, Pineda, Silvia, Chen, Bin, Aery Jones, Emily A, Choudhary, Krishna, Grone, Brian, Balestra, Maureen E, Chaudhry, Fayzan, Paranjpe, Ishan, De Freitas, Jessica, Koutsodendris, Nicole, Chen, Nuo, Wang, Celine, Chang, William, An, Alice, Glicksberg, Benjamin S, Sirota, Marina, Huang, Yadong

Get full text

Input Specificity and Dependence of Spike Timing–Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells by Zilberter, Misha, Holmgren, Carl, Shemer, Isaac, Silberberg, Gilad, Grillner, Sten, Harkany, Tibor, Zilberter, Yuri

“…Layer 2/3 (L2/3) pyramidal cells receive excitatory afferent input both from neighbouring pyramidal cells and from cortical and subcortical regions. The…”
Get full text

En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons by Usoskin, Dmitry, Zilberter, Misha, Linnarsson, Sten, Hjerling-Leffler, Jens, Uhlén, Per, Harkany, Tibor, Ernfors, Patrik

“…Perception of the environment relies on somatosensory neurons. Mechanosensory, proprioceptor and many nociceptor subtypes of these neurons have specific…”
Get full text

Unifying mechanism behind the onset of acquired epilepsy by Zilberter, Yuri, Popova, Irina, Zilberter, Misha

“…Acquired epilepsy (AE) can result from a number of brain insults and neurological diseases with wide etiological diversity sharing one common outcome of brain…”
Get full text

Reality of Inhibitory GABA in Neonatal Brain: Time to Rewrite the Textbooks? by Zilberter, Misha

Get full text

NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders by Zilberter, Yuri, Tabuena, Dennis R., Zilberter, Misha

“…Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are difficult to treat due to the lack of understanding of primary initiating…”
Get full text

GABAergic control of backpropagating action potentials in striatal medium spiny neurons by Hjorth, Johannes, Zilberter, Misha, Oliveira, Rodrigo F, Blackwell, Kim T, Hellgren Kotaleski, Jeanette

Get full text

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy by Minkeviciene, Rimante, Rheims, Sylvain, Dobszay, Marton B, Zilberter, Misha, Hartikainen, Jarmo, Fülöp, Lívia, Penke, Botond, Zilberter, Yuri, Harkany, Tibor, Pitkänen, Asla, Tanila, Heikki

“…Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms of seizure induction remain elusive. Here,…”
Get full text

Chemically defined, albumin-free human cardiomyocyte generation by Lian, Xiaojun, Bao, Xiaoping, Zilberter, Misha, Westman, Mattias, Fisahn, André, Hsiao, Cheston, Hazeltine, Laurie B, Dunn, Kaitlin K, Kamp, Timothy J, Palecek, Sean P

Get full text

Activation of NADPH oxidase is the primary trigger of epileptic seizures in rodent models by Malkov, Anton, Ivanov, Anton I, Latyshkova, Alexandra, Bregestovski, Piotr, Zilberter, Misha, Zilberter, Yuri

“…Objective: ​ Despite decades of epilepsy research, 30% of focal epilepsies remain resistant to anti-seizure drugs, with effective drug development impeded by…”
Get full text

Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation by Kurudenkandy, Firoz Roshan, Zilberter, Misha, Biverstål, Henrik, Presto, Jenny, Honcharenko, Dmytro, Strömberg, Roger, Johansson, Jan, Winblad, Bengt, Fisahn, André

“…The amyloid-β hypothesis of Alzheimer's Disease (AD) focuses on accumulation of amyloid-β peptide (Aβ) as the main culprit for the myriad physiological changes…”
Get full text