Search Results - "ZIJLSTRA, Andries"

A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells by Sung, Bong Hwan, von Lersner, Ariana, Guerrero, Jorge, Krystofiak, Evan S., Inman, David, Pelletier, Roxanne, Zijlstra, Andries, Ponik, Suzanne M., Weaver, Alissa M.

“…Small extracellular vesicles called exosomes affect multiple autocrine and paracrine cellular phenotypes. Understanding the function of exosomes requires a…”
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Directional cell movement through tissues is controlled by exosome secretion by Sung, Bong Hwan, Ketova, Tatiana, Hoshino, Daisuke, Zijlstra, Andries, Weaver, Alissa M.

“…Directional cell movement through tissues is critical for multiple biological processes and requires maintenance of polarity in the face of complex…”
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Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma by Vagner, Tatyana, Spinelli, Cristiana, Minciacchi, Valentina R., Balaj, Leonora, Zandian, Mandana, Conley, Andrew, Zijlstra, Andries, Freeman, Michael R., Demichelis, Francesca, De, Subhajyoti, Posadas, Edwin M., Tanaka, Hisashi, Di Vizio, Dolores

“…Cancer-derived extracellular vesicles (EVs) are membrane-enclosed structures of highly variable size. EVs contain a myriad of substances (proteins, lipid, RNA,…”
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Targeting tumor cell motility to prevent metastasis by Palmer, Trenis D., Ashby, William J., Lewis, John D., Zijlstra, Andries

“…Mortality and morbidity in patients with solid tumors invariably result from the disruption of normal biological function caused by disseminating tumor cells…”
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HLA-DR cancer cells expression correlates with T cell infiltration and is enriched in lung adenocarcinoma with indolent behavior by Senosain, Maria-Fernanda, Zou, Yong, Novitskaya, Tatiana, Vasiukov, Georgii, Balar, Aneri B., Rowe, Dianna J., Doxie, Deon B., Lehman, Jonathan M., Eisenberg, Rosana, Maldonado, Fabien, Zijlstra, Andries, Novitskiy, Sergey V., Irish, Jonathan M., Massion, Pierre P.

“…Lung adenocarcinoma (ADC) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. Here, we aim to…”
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The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151 by Zijlstra, Andries, Lewis, John, DeGryse, Bernard, Stuhlmann, Heidi, Quigley, James P.

“…In vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo assays and…”
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Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling by Fröse, Julia, Chen, Michelle B., Hebron, Katie E., Reinhardt, Ferenc, Hajal, Cynthia, Zijlstra, Andries, Kamm, Roger D., Weinberg, Robert A.

“…The epithelial-mesenchymal transition (EMT) endows carcinoma cells with traits needed to complete many of the steps leading to metastasis formation, but its…”
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AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking by Maacha, Selma, Hong, Jun, von Lersner, Ariana, Zijlstra, Andries, Belkhiri, Abbes

“…Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy that is characterized by resistance to chemotherapy and a poor clinical outcome. The…”
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Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice by Campbell, J Preston, Karolak, Matthew R, Ma, Yun, Perrien, Daniel S, Masood-Campbell, S Kathryn, Penner, Niki L, Munoz, Steve A, Zijlstra, Andries, Yang, Xiangli, Sterling, Julie A, Elefteriou, Florent

“…Bone and lung metastases are responsible for the majority of deaths in patients with breast cancer. Following treatment of the primary cancer, emotional and…”
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The chick embryo as an expanding experimental model for cancer and cardiovascular research by Kain, Kristin H., Miller, James W.I., Jones‐Paris, Celestial R., Thomason, Rebecca T., Lewis, John D., Bader, David M., Barnett, Joey V., Zijlstra, Andries

“…A long and productive history in biomedical research defines the chick as a model for human biology. Fundamental discoveries, including the description of…”
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Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis by Stoletov, Konstantin, Willetts, Lian, Paproski, Robert J., Bond, David J., Raha, Srijan, Jovel, Juan, Adam, Benjamin, Robertson, Amy E., Wong, Francis, Woolner, Emma, Sosnowski, Deborah L., Bismar, Tarek A., Wong, Gane Ka-Shu, Zijlstra, Andries, Lewis, John D.

“…Metastasis is the most lethal aspect of cancer, yet current therapeutic strategies do not target its key rate-limiting steps. We have previously shown that the…”
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Quantitative analysis of cancer metastasis using an avian embryo model by Palmer, Trenis D, Lewis, John, Zijlstra, Andries

“…During metastasis cancer cells disseminate from the primary tumor, invade into surrounding tissues, and spread to distant organs. Metastasis is a complex…”
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Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles by Mariscal, Javier, Vagner, Tatyana, Kim, Minhyung, Zhou, Bo, Chin, Andrew, Zandian, Mandana, Freeman, Michael R., You, Sungyong, Zijlstra, Andries, Yang, Wei, Di Vizio, Dolores

“…Extracellular vesicles (EVs) are membrane-enclosed particles that play an important role in cancer progression and have emerged as a promising source of…”
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Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer by Jovanović, Bojana, Beeler, J Scott, Pickup, Michael W, Chytil, Anna, Gorska, Agnieszka E, Ashby, William J, Lehmann, Brian D, Zijlstra, Andries, Pietenpol, Jennifer A, Moses, Harold L

“…There is a major need to better understand the molecular basis of triple negative breast cancer (TNBC) in order to develop effective therapeutic strategies…”
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The importance of developing therapies targeting the biological spectrum of metastatic disease by Zijlstra, Andries, Von Lersner, Ariana, Yu, Dihua, Borrello, Lucia, Oudin, Madeleine, Kang, Yibin, Sahai, Erik, Fingleton, Barbara, Stein, Ulrike, Cox, Thomas R., Price, John T., Kato, Yasumasa, Welm, Alana L., Aguirre-Ghiso, Julio A.

“…Great progress has been made in cancer therapeutics. However, metastasis remains the predominant cause of death from cancer. Importantly, metastasis can…”
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Sensitivity of cancer cells to truncated diphtheria toxin by Zhang, Yi, Schulte, Wendy, Pink, Desmond, Phipps, Kyle, Zijlstra, Andries, Lewis, John D, Waisman, David Morton

“…Diphtheria toxin (DT) has been utilized as a prospective anti-cancer agent for the targeted delivery of cytotoxic therapy to otherwise untreatable neoplasia…”
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Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis by Hebron, Katie E., Li, Elizabeth Y., Arnold Egloff, Shanna A., von Lersner, Ariana K., Taylor, Chase, Houkes, Joep, Flaherty, David K., Eskaros, Adel, Stricker, Thomas P., Zijlstra, Andries

“…While many adhesion receptors are known to influence tumor progression, the mechanisms by which they dynamically regulate cell-cell adhesion remain elusive. We…”
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Magnetically attachable stencils and the non-destructive analysis of the contribution made by the underlying matrix to cell migration by Ashby, William J, Wikswo, John P, Zijlstra, Andries

“…Abstract Cell migration is controlled by the integration of numerous distinct components. Consequently, the analysis of cell migration is advancing towards…”
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Integrin-Free Tetraspanin CD151 Can Inhibit Tumor Cell Motility upon Clustering and Is a Clinical Indicator of Prostate Cancer Progression by PALMER, Trenis D, MARTINEZ, Carlos H, CHIN, Joseph L, GIANNICO, Giovanna A, KETOVA, Tatiana, LEWIS, John D, ZIJLSTRA, Andries, VASQUEZ, Catalina, HEBRON, Katie E, JONES-PARIS, Celestial, ARNOLD, Shanna A, CHAN, Susanne M, CHALASANI, Venu, GOMEZ-LEMUS, Jose A, WILLIAMS, Andrew K

“…Normal physiology relies on the organization of transmembrane proteins by molecular scaffolds, such as tetraspanins. Oncogenesis frequently involves changes in…”
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Real-time visualization and quantitation of vascular permeability in vivo: implications for drug delivery by Pink, Desmond B S, Schulte, Wendy, Parseghian, Missag H, Zijlstra, Andries, Lewis, John D

“…The leaky, heterogeneous vasculature of human tumors prevents the even distribution of systemic drugs within cancer tissues. However, techniques for studying…”
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