Search Results - "ZIER, Karen"

Supportive Programs Increase Medical Students' Research Interest and Productivity by Zier, Karen, Friedman, Erica, Smith, Lawrence

“…BackgroundAdvances in biomedical research during the last decade have highlighted the necessity of attracting greater numbers of physicians to careers that…”
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Publications by Students Doing a Year of Full-Time Research: What Are Realistic Expectations? by Cohen, Benjamin L., MD, Friedman, Erica, MD, Zier, Karen, PhD

“…Clinical Research Training Program at the National Institutes for Health and Doris Duke Clinical Research Fellowship was created to provide medical and dental…”
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Goals of medical students participating in scholarly concentration programmes by Alberson, Kurt, Arora, Vineet M, Zier, Karen, Wolfson, Rachel K

“…Objectives Scholarly concentration (SC) programmes are increasingly common in medical school curricula, fostering student participation in mentored research…”
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An innovative portfolio of research training programs for medical students by Zier, Karen, Wyatt, Christina, Muller, David

“…Medical student education continues to evolve, with an increasing emphasis on evidence-based decision making in clinical settings. Many schools are introducing…”
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Surrogate Markers of Antitumor Responses: In Vitro Activation of T Cells by Autologous Tumor Peptides by ZIER, Karen, MADDUX, Jean-Marie, JOHNSON, Kristen, SUNG, Max, MANDELI, John, EISENBACH, Lea, SCHWARTZ, Myron

“…The increasing ability to augment antitumor immunity in model systems has led to increased numbers of clinical trials. However, progress in detecting immune…”
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Resection of Solid Tumors Reverses T Cell Defects and Restores Protective Immunity by Salvadori, Silvia, Martinelli, Giorgio, Zier, Karen

“…We have previously reported that CTL were demonstrable early after inoculation of CMS5 fibrosarcoma cells, but that they disappeared within 3 wk. These mice…”
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Human tumor vaccines and genetic engineering of tumors with cytokine and histocompatibility genes to enhance immunogenicity by Rosenthal, Felicia M, Zier, Karen S, Gansbacher, Bernd

“…Genetically engineered tumor cells can be used as vaccines in order to stimulate an immune response. To date, tumor cells have been modified in vitro so that…”
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A Multifaceted Program To Encourage Medical Students' Research by Zier, Karen, Stagnaro-Green, Alex

“…Describes the successful encouragement of student research provided by the Office of Student Research Opportunities (OSRO) at Mount Sinai School of Medicine…”
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Cytotoxic Lymphocytes: Basic Mechanisms and Medical Applications by Zier, Karen

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Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity by GANSBACHER, B, BANNERJI, R, DANIELS, B, ZIER, K, CRONIN, K, GILBOA, E

“…Retroviral vectors were used to introduce the gamma-interferon (IFN-gamma) gene into CMS-5 cells, a weakly immunogenic tumor of BALB/c origin. After selection…”
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Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity by GANSBACHER, B, ZIER, K, DANIELS, B, CRONIN, K, RAJAT BANNERJI, ELI GILBOA

“…To study the effects of localized secretion of cytokines on tumor progression, the gene for human interleukin 2 (IL-2) was introduced via retroviral vectors…”
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Introducing INSPIRE, a scholarly component in Undergraduate Medical education by Zier, Karen, Coplit, Lisa D.

“…Individualized learning is a fundamental tenet of the Carnegie Foundation's new recommendations for physician training. A primary goal of Mount Sinai School of…”
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Launching a New Fellowship for Medical Students: The First Years of the Doris Duke Clinical Research Fellowship Program by Gallin, Elaine K., Le Blancq, Sylvie M.

“…As part of its commitment to increasing the pipeline of physicians pursuing careers in clinical research, the Doris Duke Charitable Foundation launched the…”
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Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors by Salvadori, S, Gansbacher, B, Pizzimenti, AM, Zier, KS

“…There is considerable evidence to demonstrate that immune function is abnormal in tumor-bearing mice, perhaps accounting, at least in part, for progressive…”
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Molecular basis of T cell dysfunction in cancer is influenced by the paracrine secretion of tumor-derived IL-2 by Salvadori, S, Zier, K

“…Previously we reported that T cells from mice bearing parental tumors have a variety of functional and biochemical defects when compared with T cells from mice…”
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T-cell responses to multiple antigens presented by RNA-transfected APCs: a possible immunomonitoring tool by BARTIDO, Shirley M, ZIER, Karen

“…The increasingly deeper understanding of how the immune system recognizes and destroys tumors promises to enable the development of new approaches for gene…”
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Cell Mediated Immunity: Separation of Cells Involved in Recognitive and Destructive Phases by Bach, Fritz H., Segall, Miriam, Zier, Karen Stouber, Sondel, Paul M., Alter, Barbara J., Bach, Marilyn L.

“…The mixed leukocyte culture (MLC) and the cell mediated lympholysis (CML) assays are used as in vitro models of the afferent, or recognitive, and efferent, or…”
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B7-1 amplifies the response to interleukin-2-secreting tumor vaccines in vivo, but fails to induce a response by naive cells in vitro by Salvadori, S, Gansbacher, B, Wernick, I, Tirelli, S, Zier, K

“…Parental and interleukin-2 (IL-2)-secreting CMS5 tumor cells were transfected with the B7-1 costimulatory molecule to amplify anti-tumor responses. CMS5 cells…”
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The impact of gene therapy on T cell function in cancer by Zier, K S, Gansbacher, B

“…Studies of signal transduction by T cells are slowly identifying the intracellular messengers that must be generated for full T cell activation to take place…”
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IFNγ secretion following stimulation with total tumor peptides from autologous human tumors by Zier, Karen, Johnson, Kristen, Maddux, Jean-Marie, Sung, Max, Mandeli, John, Eisenbach, Lea, Schwartz, Myron

“…Several issues remain to be resolved before the efficacy of various approaches to elicit anti-tumor immunity in patients can be evaluated. First, in vitro…”
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