Search Results - "ZIER, K. S"

Tumour cell vaccines that secrete interleukin-2 (IL-2) and interferonγ (IFN-γ) are recognised by T cells while resisting destruction by natural killer (NK) cells by Zier, K.S., Gansbacher, B.

“…The inoculation into mice of genetically engineered tumour cells that secrete IL-2 or IFNγ results in rejection, while unmodified parental tumour cells grow…”
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IL-2 gene therapy of solid tumors : an approach for the prevention of signal transduction defects in T cells by ZIER, K. S, GANSBACHER, B

“…The identification of tumor-associated antigens has focused attention on the mechanisms that underlie the failure of T cells to destroy tumor cells. A deeper…”
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Generation of anti-allogeneic cytotoxic T lymphocytes depends upon a signal, not delivered by tumor cells, that can be provided in trans in the presence of exogenous interleukin-2 by ZIER, K. S, SALVADORI, S

“…We have reported that, while immune responses were generated initially against CMS5 tumor cells, they were lost with time. In the present work, we asked…”
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The control of class II expression on T cells is independent of the regulation of Tac and the induction of proliferation by SALVADORI, S., PIZZIMENTI, A., COHEN, S., ZIER, K. S.

“…SUMMARY In order to define the association between class II expression and other markers of T cell activation we tested the ability of various modes of…”
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Vaccination with IL-2-secreting tumor cells stimulates the generation of IL-2-responsive T cells and prevents the development of unresponsiveness by Zier, K S, Salvadori, S, Cronin, K C, Gansbacher, B

“…Infection of CMS5 tumor cells with retroviral constructs containing interleukin-2 (IL-2) cDNA and selection in medium supplemented with G418 resulted in the…”
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HLA class II mRNA accumulation by activated human T cells following growth in conditioned medium by GANSBACHER, B, ZIER, K. S

“…The expression of HLA Class II beta genes by seven CD4- or CD8-positive T cell clones grown in conditioned medium was examined on the mRNA and cell surface…”
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Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus by ZIER, K. S, LEO, M. M, SPIELMAN, R. S, BAKER, L

“…Synthesis of interleukin-2 (IL-2) by lymphocytes from 26 insulin-dependent diabetic subjects (IDDM) was compared with that by lymphocytes from 24 nondiabetic…”
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Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus by Zier, K. S., Leo, M. M., Spielman, R. S., Baker, L.

“…Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. K S Zier , M M Leo , R S Spielman and L Baker Abstract Synthesis of…”
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Regulation of HLA-DR, DP, and DQ expression in activated T cells by Gansbacher, B, Zier, K S

“…Class II expression following restimulation of a population of T cells which had first been activated and then allowed to revert to small resting cells via…”
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Presentation of Class I antigens on T cells can induce the generation of antigen-specific CTL by Zier, KS, Pickard, AR

“…Cytotoxic T lymphocyte (CTL) lines generally require a source of specific antigen to continue to proliferate in vitro. We previously showed that populations of…”
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Tumor-bearing animals contain suppressed antitumor effectors the function of which can be unmasked by IL-2 by Salvadori, S, Rosenthal, F M, Cronin, K, Gansbacher, B, Zier, K S

“…CMS5 fibrosarcoma cells were infected with retroviral constructs containing interleukin-2 (IL-2) cDNA and selected in G418. Parental tumor cells and those that…”
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Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors by Salvadori, S, Gansbacher, B, Pizzimenti, AM, Zier, KS

“…There is considerable evidence to demonstrate that immune function is abnormal in tumor-bearing mice, perhaps accounting, at least in part, for progressive…”
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Negative signal transmission through class II molecules on activated T cells by Urban, N D, Zier, K S

“…Major histocompatibility complex class II antigens are expressed on human T cells following activation, but their functional role remains obscure. We have…”
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The development of cell mediated immunity: very young children have strong LAK activity by Pierson, G R, Evans, A E, Zier, K S

“…We were interested in evaluating immune function in very young children with cancer who were treated with gamma-interferon on a sequential basis. Though…”
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Proliferative T cell clones directed at a human minor antigen by Zier, K S

“…Clones directed against a human minor antigen were isolated from an interleukin-2-dependent cytotoxic T cell line. As expected, some clones exhibiting…”
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The impact of gene therapy on T cell function in cancer by Zier, K S, Gansbacher, B

“…Studies of signal transduction by T cells are slowly identifying the intracellular messengers that must be generated for full T cell activation to take place…”
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The response pattern of human T cells to stimulation following expansion in IL-2 by Shah, U, Cutilli, J R, Zier, K S

“…The ability to stimulate and induce responses of T cells is influenced by their age and state of differentiation. We have examined the response upon…”
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The detection of human minor alloantigens following restriction determinant implantation by Zier, K S, Volsky, D J, Sinangil, F

“…The recognition of minor alloantigens by cytotoxic T lymphocytes (CTL) serves as a model for the recognition of tumor and viral antigens. Progress in this area…”
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Restimulation in secondary MLC by autologous non-T cells by Zier, K S, Huber, C, Braunsteiner, H

“…Lymphocytes sensitized in mixed leucocyte culture (MLC) were restimulated with non-T or complete cells. Cells primed against autologous non-T cells and…”
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Human tumor vaccines and genetic engineering of tumors with cytokine and histocompatibility genes to enhance immunogenicity by Rosenthal, Felicia M, Zier, Karen S, Gansbacher, Bernd

“…Genetically engineered tumor cells can be used as vaccines in order to stimulate an immune response. To date, tumor cells have been modified in vitro so that…”
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