Search Results - "ZIEMSSEN, T"

Patient‐ versus physician‐reported relapses in multiple sclerosis: insights from a large observational study by Schriefer, D., Haase, R., Ettle, B., Ziemssen, T.

“…Background and purpose The patient's perspective is becoming increasingly important for endpoints in studies on multiple sclerosis. However, relapse data…”
Get full text

Perceptions on the value of bodily functions in multiple sclerosis by Heesen, C., Haase, R., Melzig, S., Poettgen, J., Berghoff, M., Paul, F., Zettl, U., Marziniak, M., Angstwurm, K., Kern, R., Ziemssen, T., Stellmann, J. P.

“…Background In neurological diseases presenting with a plethora of symptoms, the value of bodily functions for a given patient might be a guide for clinical…”
Get full text

Immunomodulatory treatments and cognition in MS by Mückschel, M., Beste, C., Ziemssen, T.

“…Cognitive impairments occur frequently and early in multiple sclerosis (MS) and contribute significantly to a reduced quality of life of patients with MS…”
Get full text

New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies by Sehr, T, Proschmann, U, Thomas, K, Marggraf, M, Straube, E, Reichmann, H, Chan, A, Ziemssen, T

“…The monoclonal antibody natalizumab (NAT) inhibits the migration of lymphocytes throughout the blood-brain barrier by blocking very late antigen (VLA)-4…”
Get full text

Adrenal medullary dysfunction as a feature of obesity by Reimann, M, Qin, N, Gruber, M, Bornstein, S R, Kirschbaum, C, Ziemssen, T, Eisenhofer, G

“…Background and Objective: Although there is strong evidence linking obesity with increased sympathoneural activity, involvement of the adrenal medulla is less…”
Get full text

Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination by Choi, E Y, Lim, J-H, Neuwirth, A, Economopoulou, M, Chatzigeorgiou, A, Chung, K-J, Bittner, S, Lee, S-H, Langer, H, Samus, M, Kim, H, Cho, G-S, Ziemssen, T, Bdeir, K, Chavakis, E, Koh, J-Y, Boon, L, Hosur, K, Bornstein, S R, Meuth, S G, Hajishengallis, G, Chavakis, T

“…Inflammation in the central nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogenesis of multiple sclerosis (MS)…”
Get full text

Evaluation of Study and Patient Characteristics of Clinical Studies in Primary Progressive Multiple Sclerosis: A Systematic Review by Ziemssen, T, Rauer, S, Stadelmann, C, Henze, T, Koehler, J, Penner, I-K, Lang, M, Poehlau, D, Baier-Ebert, M, Schieb, H, Meuth, S

“…So far, clinical studies in primary progressive MS (PPMS) have failed to meet their primary efficacy endpoints. To some extent this might be attributable to…”
Get full text

Real-world evidence : Benefits and limitations in multiple sclerosis research by Ziemssen, T, Rothenbacher, D, Kuhle, J, Berger, T

“…Real-world evidence (RWE) expands the data obtained in randomized clinical trials (RCTs), which are based on both homogeneous selected patient groups and…”
Get full text

Multiple sclerosis registries in Europe – An updated mapping survey by Glaser, A., Stahmann, A., Meissner, T., Flachenecker, P., Horáková, D., Zaratin, P., Brichetto, G., Pugliatti, M., Rienhoff, O., Vukusic, S., de Giacomoni, A.C., Battaglia, M.A., Brola, W., Butzkueven, H., Casey, R., Drulovic, J., Eichstädt, K., Hellwig, K., Iaffaldano, P., Ioannidou, E., Kuhle, J., Lycke, K., Magyari, M., Malbaša, T., Middleton, R., Myhr, K.M., Notas, K., Orologas, A., Otero-Romero, S., Pekmezovic, T., Sastre-Garriga, J., Seeldrayers, P., Soilu-Hänninen, M., Stawiarz, L., Trojano, M., Ziemssen, T., Hillert, J., Thalheim, C.

“…•Nineteen questionnaires from European MS registries were analysed.•Aim and focus as well as number of patients and inclusion criteria vary considerably.•Most…”
Get full text

Circadian cortisol, depressive symptoms and neurological impairment in early multiple sclerosis by Kern, S, Schultheiß, T, Schneider, H, Schrempf, W, Reichmann, H, Ziemssen, T

“…Summary Objective There is evidence for the existence of a hyperactive hypothalamus–pituitary–adrenal (HPA) axis and its potential role in disease progression…”
Get full text

Brain-immune communication psychoneuroimmunology of multiple sclerosis by KERN, S, ZIEMSSEN, T

“…The central nervous system (CNS) and the immune system are two extremely complex and highly adaptive systems. In the face of a real or anticipated threat, be…”
Get full text

6-sulpho LacNAc+ dendritic cells accumulate in various inflammatory, but not ischaemic conditions of the central nervous system by Thomas, K., Metz, I., Tumani, H., Brück, W., Ziemssen, T.

Get full text

Glatiramer acetate‐specific T‐helper 1‐ and 2‐type cell lines produce BDNF: implications for multiple sclerosis therapy by Ziemssen, Tjalf, Kümpfel, Tania, Klinkert, Wolfgang E. F., Neuhaus, Oliver, Hohlfeld, Reinhard

“…The clinical effects of glatiramer acetate (GA), an approved therapy for multiple sclerosis, are thought to be largely mediated by a T‐helper 1 (TH1) to…”
Get full text

Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study by Smith, A J, Malan, L, Uys, A S, Malan, N T, Harvey, B H, Ziemssen, T

“…Brain-derived neurotrophic factor (BDNF) has been linked to neurological pathologies, but its role in cardiometabolic disturbances is limited. We aimed to…”
Get full text

Defensive coping facilitates higher blood pressure and early sub-clinical structural vascular disease via alterations in heart rate variability: The SABPA study by Malan, L, Hamer, M, Schlaich, M.P, Lambert, G, Ziemssen, T, Reimann, M, Frasure-Smith, N, Amirkhan, J.H, Schutte, R, van Rooyen, J.M, Mels, C.M, Fourie, C.M.T, Uys, A.S, Malan, N.T

“…Abstract Objectives Defensive coping (AC) responses in urban African males have been associated with vascular responsiveness, partly explaining autonomic…”
Get full text

CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function by Jing, D, Oelschlaegel, U, Ordemann, R, Hölig, K, Ehninger, G, Reichmann, H, Ziemssen, T, Bornhäuser, M

“…Therapeutic application of natalizumab, an anti-CD49d Ab, in patients with multiple sclerosis (MS) has been associated with increased levels of circulating…”
Get full text

Neurological disability, psychological distress, and health-related quality of life in MS patients within the first three years after diagnosis by Kern, S, Schrempf, W, Schneider, H, Schultheiß, T, Reichmann, H, Ziemssen, T

“…Background Psychological distress and psychiatric co-morbidity are common in multiple sclerosis (MS) and is often associated with neurological disability as…”
Get full text

Education research: cognitive performance is preserved in sleep-deprived neurology residents by Reimann, M, Manz, R, Prieur, S, Reichmann, H, Ziemssen, T

“…To test the hypotheses that sleep deprivation in neurology residents is associated with performance deficits and that vigilance and cognitive performance is…”
Get full text

Rapidly progressive course of very late onset multiple sclerosis presenting with Parkinsonism: case report by Schultheiss, T, Reichmann, H, Ziemssen, T

“…Multiple sclerosis mainly affects young adolescents, making late-onset multiple sclerosis a rarity and diagnostic challenge, particularly for cases after age…”
Get full text

Axon-reflex based nerve fiber function assessment in the detection of autonomic neuropathy by Siepmann, T, Illigens, B M-W, Reichmann, H, Ziemssen, T

“…Axon-reflex-based tests of peripheral small nerve fiber function including techniques to quantify vasomotor and sudomotor responses following acetylcholine…”
Get full text