Search Results - "ZIEMNIAK, J. A"

The contribution of intestinal secretion to the dose-dependent absorption of celiprolol by SHIU-MING KUO, WHITBY, B. R, ARTURSSON, P, ZIEMNIAK, J. A

“…The contribution of the intestine to the nonlinear absorption of celiprolol in the rat was studied. After intravenous administration of 14C-celiprolol to bile…”
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Dispositional characteristics of a tyrosine kinase inhibitor (RG 14620) in rats and rabbits following intravenous administration or dermal application by Khetarpal, V K, Markham, P M, Ziemniak, J A

“…Based on its epidermal growth factor receptor-mediated tyrosine kinase inhibitory activity, (Z)-alpha-[(3,5-dichlorophenyl)methylene]-3- pyridylacetonitrile…”
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Inhaled corticosteroids in asthma: a dose-proportionality study with triamcinolone acetonide aerosol by Zaborny, B A, Lukacsko, P, Barinov-Colligon, I, Ziemniak, J A

“…The systemic exposure to triamcinolone acetonide (TAA) after inhalation of aerosolized drug has not been examined previously. This study evaluates the plasma…”
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The effect of acetaminophen on the disposition of fenoldopam: competition for sulfation by Ziemniak, J A, Allison, N, Boppana, V K, Dubb, J, Stote, R

“…Both fenoldopam and acetaminophen undergo conjugation with sulfate in humans. The present study was undertaken to determine if a metabolic interaction exists…”
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The effect of fenoldopam, a dopaminergic agonist, on renal hemodynamics by Allison, N L, Dubb, J W, Ziemniak, J A, Alexander, F, Stote, R M

“…Fenoldopam, a dopaminergic agonist, was administered intravenously to 18 healthy male subjects in doses ranging from 0.025 to 1.0 microgram/kg/min for 2 hours…”
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Pharmacokinetic and pharmacodynamic properties of intravenous fenoldopam, a dopamine1‐receptor agonist, in hypertensive patients by Weber, RR, McCoy, CE, Ziemniak, JA, Frederickson, ED, Goldberg, LI, Murphy, MB

“…1 The pharmacokinetic properties of intravenous fenoldopam, a selective dopamine1‐receptor agonist, were studied in 10 patients with essential hypertension. 2…”
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Cimetidine pharmacokinetics in patients with Zollinger-Ellison syndrome by McArthur, K E, Raufman, J P, Seaman, J J, Ziemniak, J A, Gardner, J D, Jensen, R T

“…Although most patients with Zollinger-Ellison syndrome can be effectively treated with histamine H2-receptor antagonists, many patients require large doses of…”
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The partitioning of cimetidine into canine cerebrospinal fluid by Ziemniak, J A, Shank, R G, Schentag, J J

“…The pharmacokinetics and cerebrospinal fluid (CSF) partitioning of cimetidine were studied in the dog. Four healthy male mongrel dogs were given a 22 mg/kg iv…”
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Immobilized sulfatase:beta-glucuronidase enzymes for the qualitative and quantitative analysis of drug conjugates by Boppana, V K, Lynn, R K, Ziemniak, J A

“…The enzymes sulfatase and beta-glucuronidase from Helix pomatia were simultaneously immobilized on aminopropyl control pore glass. Once immobilized, these…”
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Liquid-chromatographic determination of cimetidine, its known metabolites, and creatinine in serum and urine by Ziemniak, J A, Chiarmonte, D A, Schentag, J J

“…We describe a liquid-chromatographic procedure for determination of cimetidine, its hydroxymethyl-, sulfoxide-, and guanyl urea metabolites, and creatinine in…”
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The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults by ZIEMNIAK, J. A, ASSAEL, B. M, PADOAN, R, SCHENTAG, J. J

“…The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12.6 years) after oral and intravenous…”
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A retrospective analysis of fenoldopam renal excretion in 65 subjects: evidence for possible intrarenal formation of fenoldopam from its metabolites by ZIEMNIAK, J. A, BOPPANA, V. K, CYRONAK, M. J, STOTE, R. M

“…Clinical studies have suggested that the dopamine DA1 agonist, fenoldopam, may exhibit nonlinear renal excretion in humans. A retrospective population…”
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Analysis of epinine and its metabolites in man after oral administration of its pro-drug ibopamine using high-performance liquid chromatography with electrochemical detection by Gifford, R, Randolph, W C, Heineman, F C, Ziemniak, J A

“…Ibopamine (N-methyldopamine O,O'-diisobutyrol ester, hydrochloride) is an ester prodrug of epinine. Epinine is a cardiovascular agent used in congestive heart…”
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Hepatic encephalopathy and altered cimetidine kinetics by Ziemniak, J A, Bernhard, H, Schentag, J J

“…Cimetidine kinetics were followed in 16 cirrhotic patients after a single IV 300-mg dose. The patients were grouped according to a history of portal systemic…”
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Ranitidine disposition and systemic availability in hepatic cirrhosis by Smith, I L, Ziemniak, J A, Bernhard, H, Eshelman, F N, Martin, L E, Schentag, J J

“…Single-dose ranitidine kinetics were studied in 10 patients with cirrhosis as proved by liver biopsy. All were clinically stable. After an overnight fast,…”
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Failure of cimetidine in Zollinger-Ellison syndrome by ZIEMNIAK, J. A, MADURA, M, ADAMONIS, A. J, OLINGER, E. J, DREYER, M, SCHENTAG, J. J

“…Both the pharmacokinetics and the pharmacodynamics of cimetidine were investigated in three patients with Zollinger-Ellison syndrome, who were unresponsive to…”
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Pharmacoscintigraphic evaluation of a modified release (Geomatrix®) diltiazem formulation by Wilding, Ian R., Davis, Stanley S., Sparrow, Robert A., Ziemniak, John A., Heald, Donald L.

“…The gastrointestinal transit and in vivo release behaviour of a modified release (Geomatrix®) diltiazem formulation has been evaluated by the combined…”
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The pharmacokinetics and metabolism of cimetidine in neonates by Ziemniak, J A, Wynn, R J, Aranda, J V, Zarowitz, B J, Schentag, J J

“…Cimetidine pharmacokinetics and metabolism were studied in 2 full-term and 1 premature neonates. All infants demonstrated the capacity to eliminate cimetidine…”
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HPLC determination of D and L moxalactam in human serum and urine by Ziemniak, J A, Chiarmonte, D A, Miner, D J, Schentag, J J

“…A high-pressure liquid chromatographic procedure was developed to determine the D and L isomers of moxalactam in human plasma and urine. After protein…”
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Determination of fenoldopam (SK&F 82526) and its metabolites in human plasma and urine by high-performance liquid chromatography with electrochemical detection by Boppana, V K, Heineman, F C, Lynn, R K, Randolph, W C, Ziemniak, J A

“…Fenoldopam [6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-di ol] is a potent renal vasodilator that is currently undergoing Phase II…”
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