Search Results - "ZIEBUHR, John"

Multi-level inhibition of coronavirus replication by chemical ER stress by Shaban, Mohammed Samer, Müller, Christin, Mayr-Buro, Christin, Weiser, Hendrik, Meier-Soelch, Johanna, Albert, Benadict Vincent, Weber, Axel, Linne, Uwe, Hain, Torsten, Babayev, Ilya, Karl, Nadja, Hofmann, Nina, Becker, Stephan, Herold, Susanne, Schmitz, M. Lienhard, Ziebuhr, John, Kracht, Michael

“…Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming…”
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Ribose 2′- O -methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 by Thiel, Volker, Züst, Roland, Cervantes-Barragan, Luisa, Habjan, Matthias, Maier, Reinhard, Neuman, Benjamin W, Ziebuhr, John, Szretter, Kristy J, Baker, Susan C, Barchet, Winfried, Diamond, Michael S, Siddell, Stuart G, Ludewig, Burkhard

“…The biological role of 2′- O -methylation of host and viral mRNA has remained elusive. Thiel and co-workers show that this modification modulates the induction…”
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Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions by Madhugiri, Ramakanth, Karl, Nadja, Petersen, Daniel, Lamkiewicz, Kevin, Fricke, Markus, Wend, Ulrike, Scheuer, Robina, Marz, Manja, Ziebuhr, John

“…Structure predictions suggest a partial conservation of RNA structure elements in coronavirus terminal genome regions. Here, we determined the structures of…”
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Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA by Habjan, Matthias, Hubel, Philipp, Lacerda, Livia, Benda, Christian, Holze, Cathleen, Eberl, Christian H., Mann, Angelika, Kindler, Eveline, Gil-Cruz, Cristina, Ziebuhr, John, Thiel, Volker, Pichlmair, Andreas

“…Viruses that generate capped RNA lacking 2′O methylation on the first ribose are severely affected by the antiviral activity of Type I interferons. We used…”
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The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells by Poppe, Michael, Wittig, Sascha, Jurida, Liane, Bartkuhn, Marek, Wilhelm, Jochen, Müller, Helmut, Beuerlein, Knut, Karl, Nadja, Bhuju, Sabin, Ziebuhr, John, Schmitz, M Lienhard, Kracht, Michael

“…Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more…”
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Evidence for Substrate Binding-Induced Zwitterion Formation in the Catalytic Cys-His Dyad of the SARS-CoV Main Protease by Paasche, Alexander, Zipper, Andreas, Schäfer, Simon, Ziebuhr, John, Schirmeister, Tanja, Engels, Bernd

“…The coronavirus main protease (Mpro) represents an attractive drug target for antiviral therapy of coronavirus (CoV) infections, including severe acute…”
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Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution by Jungreis, Irwin, Nelson, Chase W., Ardern, Zachary, Finkel, Yaara, Krogan, Nevan J., Sato, Kei, Ziebuhr, John, Stern-Ginossar, Noam, Pavesi, Angelo, Firth, Andrew E., Gorbalenya, Alexander E., Kellis, Manolis

“…At least six small alternative-frame open reading frames (ORFs) overlapping well-characterized SARS-CoV-2 genes have been hypothesized to encode accessory…”
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Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology by Zhao, Ling, Jha, Babal K., Wu, Ashley, Elliott, Ruth, Ziebuhr, John, Gorbalenya, Alexander E., Silverman, Robert H., Weiss, Susan R.

“…Many viruses induce hepatitis in humans, highlighting the need to understand the underlying mechanisms of virus-induced liver pathology. The murine…”
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RNA structure analysis of alphacoronavirus terminal genome regions by Madhugiri, Ramakanth, Fricke, Markus, Marz, Manja, Ziebuhr, John

“…•Review of current knowledge of cis-acting RNA elements essential to coronavirus replication.•Identification of RNA structural elements in alphacoronavirus…”
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Reply to: The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein by Shaban, Mohammed Samer, Müller, Christin, Mayr-Buro, Christin, Weiser, Hendrik, Schmitz, M. Lienhard, Ziebuhr, John, Kracht, Michael

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Identification and Characterization of Genetically Divergent Members of the Newly Established Family Mesoniviridae by Zirkel, Florian, Roth, Hanna, Kurth, Andreas, Drosten, Christian, Ziebuhr, John, Junglen, Sandra

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Coronavirus Main Proteinase ($3CL^{pro}$) Structure: Basis for Design of Anti-SARS Drugs by Anand, Kanchan, Ziebuhr, John, Wadhwani, Parvesh, Mesters, Jeroen R., Hilgenfeld, Rolf

“…A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (Mpro, also…”
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Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol by Müller, Christin, Obermann, Wiebke, Schulte, Falk W., Lange-Grünweller, Kerstin, Oestereich, Lisa, Elgner, Fabian, Glitscher, Mirco, Hildt, Eberhard, Singh, Kamini, Wendel, Hans-Guido, Hartmann, Roland K., Ziebuhr, John, Grünweller, Arnold

“…Rocaglates, a class of natural compounds isolated from plants of the genus Aglaia, are potent inhibitors of translation initiation. They are proposed to form…”
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The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo by Müller, Christin, Obermann, Wiebke, Karl, Nadja, Wendel, Hans-Guido, Taroncher-Oldenburg, Gaspar, Pleschka, Stephan, Hartmann, Roland K., Grünweller, Arnold, Ziebuhr, John

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, a severe respiratory disease with varying clinical…”
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Discovery of an RNA Virus 3'→5' Exoribonuclease That Is Critically Involved in Coronavirus RNA Synthesis by Minskaia, Ekaterina, Hertzig, Tobias, Gorbalenya, Alexander E., Campanacci, Valérie, Cambillau, Christian, Canards, Bruno, Ziebuhr, John

“…Replication of the giant RNA genome of severe acute respiratory syndrome (SARS) coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are…”
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Nidovirus ribonucleases: Structures and functions in viral replication by Ulferts, Rachel, Ziebuhr, John

“…Nidoviruses employ unique strategies to replicate and express their exceptionally large RNA genomes. The viruses use a variety of enzymes to synthesize, modify…”
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Conservation of substrate specificities among coronavirus main proteases by Hegyi, A, Ziebuhr, J

“…The key enzyme in coronavirus replicase polyprotein processing is the coronavirus main protease, 3CL(pro). The substrate specificities of five coronavirus main…”
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Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses by Lauber, Chris, Ziebuhr, John, Junglen, Sandra, Drosten, Christian, Zirkel, Florian, Nga, Phan Thi, Morita, Kouichi, Snijder, Eric J., Gorbalenya, Alexander E.

“…Recently, two independent surveillance studies in Côte d’Ivoire and Vietnam, respectively, led to the discovery of two mosquito-borne viruses, Cavally virus…”
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Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage by Snijder, Eric J, Bredenbeek, Peter J, Dobbe, Jessika C, Thiel, Volker, Ziebuhr, John, Poon, Leo L M, Guan, Yi, Rozanov, Mikhail, Spaan, Willy J M, Gorbalenya, Alexander E

“…The genome organization and expression strategy of the newly identified severe acute respiratory syndrome coronavirus (SARS-CoV) were predicted using recently…”
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A Novel Insertion in the Hepatitis B Virus Surface Protein Leading to Hyperglycosylation Causes Diagnostic and Immune Escape by Lehmann, Felix, Slanina, Heiko, Roderfeld, Martin, Roeb, Elke, Trebicka, Jonel, Ziebuhr, John, Gerlich, Wolfram H, Schüttler, Christian G, Schlevogt, Bernhard, Glebe, Dieter

“…Chronic hepatitis B virus (HBV) infection is a global health threat. Mutations in the surface antigen of HBV (HBsAg) may alter its antigenicity, infectivity,…”
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