Search Results - "ZHU, Chang Z"

A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat by Honore, Prisca, Donnelly-Roberts, Diana, Namovic, Marian T, Hsieh, Gin, Zhu, Chang Z, Mikusa, Joe P, Hernandez, Gricelda, Zhong, Chengmin, Gauvin, Donna M, Chandran, Prasant, Harris, Richard, Medrano, Arturo Perez, Carroll, William, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F

“…ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system. Activation of P2X(7)…”
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Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity by Frost, Jennifer M, Dart, Michael J, Tietje, Karin R, Garrison, Tiffany R, Grayson, George K, Daza, Anthony V, El-Kouhen, Odile F, Yao, Betty B, Hsieh, Gin C, Pai, Madhavi, Zhu, Chang Z, Chandran, Prasant, Meyer, Michael D

“…Several 3-acylindoles with high affinity for the CB2 cannabinoid receptor and selectivity over the CB1 receptor have been prepared. A variety of 3-acyl…”
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Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats by Hsieh, Gin C, Pai, Madhavi, Chandran, Prasant, Hooker, Bradley A, Zhu, Chang Z, Salyers, Anita K, Wensink, Erica J, Zhan, CenChen, Carroll, William A, Dart, Michael J, Yao, Betty B, Honore, Prisca, Meyer, Michael D

“…BACKGROUND AND PURPOSE Cannabinoid CB2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of…”
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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat by Jarvis, Michael F, Burgard, Edward C, McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J, Subieta, Alberto, Van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T, Zhu, Chang Z, Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O, Polakowski, James, Cox, Bryan F, Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie

“…P2X 3 and P2X 2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes…”
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Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats by Zhu, Chang Z., Doyle, Kelly J., Nikkel, Arthur L., Olsen, Lauren, Namovic, Marian T., Salte, Katherine, Widomski, Deborah, Su, Zhi, Donnelly-Roberts, Diana L., Gopalakrishnan, Murali M., McGaraughty, Steve

“…The adenine model of kidney disease typically involves dietary delivery of adenine over several weeks. This model can be variable in its disease progression…”
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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats by Honore, Prisca, Wismer, Carol T, Mikusa, Joe, Zhu, Chang Z, Zhong, Chengmin, Gauvin, Donna M, Gomtsyan, Arthur, El Kouhen, Rachid, Lee, Chih-Hung, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F

“…The vanilloid receptor 1 (VR1, TRPV1), which is a member of the transient receptor potential (TRP) superfamily, is highly localized on peripheral and central…”
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Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging by Yao, Betty B, Hsieh, Gin, Daza, Anthony V, Fan, Yihong, Grayson, George K, Garrison, Tiffany Runyan, El Kouhen, Odile, Hooker, Bradley A, Pai, Madhavi, Wensink, Erica J, Salyers, Anita K, Chandran, Prasant, Zhu, Chang Z, Zhong, Chengmin, Ryther, Keith, Gallagher, Megan E, Chin, Chih-Liang, Tovcimak, Ann E, Hradil, Vincent P, Fox, Gerard B, Dart, Michael J, Honore, Prisca, Meyer, Michael D

“…Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB(2) receptor activation have been largely derived from the use of…”
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Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia by ZHU, Chang Z, AUER, Roland N

“…Insulin has been shown to ameliorate cerebral necrosis in global and, more recently, in focal cerebral ischemia. The goal of this study was to determine the…”
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Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities by Zhu, Chang Z., Wilson, Sonya G., Mikusa, Joseph P., Wismer, Carol T., Gauvin, Donna M., Lynch, James J., Wade, Carrie L., Decker, Michael W., Honore, Prisca

“…Preclinical data, performed in a limited number of pain models, suggest that functional blockade of metabotropic glutamate (mGlu) receptors may be beneficial…”
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Role of central and peripheral mGluR5 receptors in post-operative pain in rats by Zhu, Chang Z., Hsieh, Gin, EI-Kouhen, Odile, Wilson, Sonya G., Mikusa, Joe P., Hollingsworth, Peter R., Chang, Renjie, Moreland, Robert B., Brioni, Jorge, Decker, Michael W., Honore, Prisca

“…Metabotropic glutamate receptors (mGluRs) have previously been shown to play a role in pain transmission during inflammatory or neuropathic pain states…”
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Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats by Zhu, Chang Z., Baker, Scott, EI-Kouhen, Odile, Lehto, Sonya G., Hollingsworth, Peter R., Gauvin, Donna M., Hernandez, Gricelda, Zheng, GuoZhu, Chang, Renjie, Moreland, Robert B., Stewart, Andrew O., Brioni, Jorge D., Honore, Prisca

“…Activation of metabotropic glutamate (mGlu) receptors has previously been shown to play a role in inflammatory or neuropathic pain states. However, the role of…”
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Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury by Zhang, Xu-Feng, Zhu, Chang Z, Thimmapaya, Rama, Choi, Won S, Honore, Prisca, Scott, Victoria E, Kroeger, Paul E, Sullivan, James P, Faltynek, Connie R, Gopalakrishnan, Murali, Shieh, Char-Chang

“…The profile of tetrodotoxin sensitive (TTX-S) and resistant (TTX-R) Na + channels and their contribution to action potentials and firing patterns were studied…”
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Targeting Anti-TGF- β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach by McGaraughty, Steve, Davis-Taber, Rachel A, Zhu, Chang Z, Cole, Todd B, Nikkel, Arthur L, Chhaya, Meha, Doyle, Kelly J, Olson, Lauren M, Preston, Gregory M, Grinnell, Christine M, Salte, Katherine M, Giamis, Anthony M, Luo, Yanping, Sun, Victor, Goodearl, Andrew D, Gopalakrishnan, Murali, Lacy, Susan E

“…Targeted delivery of a therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment…”
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Central and peripheral sites of action for CB 2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats by Hsieh, Gin C, Pai, Madhavi, Chandran, Prasant, Hooker, Bradley A, Zhu, Chang Z, Salyers, Anita K, Wensink, Erica J, Zhan, CenChen, Carroll, William A, Dart, Michael J, Yao, Betty B, Honore, Prisca, Meyer, Michael D

“…BACKGROUND AND PURPOSE Cannabinoid CB 2 receptor activation by selective agonists has been shown to produce analgesic effects in preclinical models of…”
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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain by Drizin, Irene, Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Carroll, William A., Marron, Brian E., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhu, Chang Z., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Roeloffs, Rosemarie, Werness, Stephen, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Kort, Michael E.

“… The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were…”
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Effects of A‐317491, a novel and selective P2X 3 /P2X 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration by McGaraughty, Steve, Wismer, Carol T, Zhu, Chang Z, Mikusa, Joseph, Honore, Prisca, Chu, Katharine L, Lee, Chih‐Hung, Faltynek, Connie R, Jarvis, Michael F

“…We have recently reported that systemic delivery of A‐317491, the first non‐nucleotide antagonist that has high affinity and selectivity for blocking P2X 3…”
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Dissociation between post-surgical pain behaviors and spinal Fos-like immunoreactivity in the rat by Zhu, Chang Z., Nikkel, Arthur L., Martino, Brenda, Bitner, Robert S., Decker, Michael W., Honore, Prisca

“…Previous studies have demonstrated that Fos-like immunoreactivity is increased in spinal dorsal horn neurons in several pain models, and have suggested that…”
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Potentiation of analgesic efficacy but not side effects: Co-administration of an alpha 4 beta 2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats by Zhu, Chang Z, Chin, Chih-Liang, Rustay, Nathan R, Zhong, Chengmin, Mikusa, Joe, Chandran, Prasant, Salyers, Anita, Gomez, Erica, Simler, Gricelda, Lewis, La Geisha, Gauvin, Donna, Baker, Scott, Pai, Madhavi, Tovcimak, Ann, Brown, Jordan, Komater, Victoria, Fox, Gerard B, Decker, Michael W, Jacobson, Peer B, Gopalakrishnan, Murali, Lee, Chih-Hung, Honore, Prisca

“…Positive modulation of the neuronal nicotinic acetylcholine receptor (nAChR) alpha 4 beta 2 subtype by selective positive allosteric modulator NS-9283 has…”
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A-306989, an inhibitor of adenosine kinase, is renoprotective in rodent models of podocyte, basement membrane, and obstructive injury by Zhu, Chang Z., Gopalakrishnan, Sujatha, Doyle, Kelly, Nikkel, Arthur L., Olson, Lauren, Abraham, Vivek C., Leys, Laura, Widomski, Deborah, Salte, Katherine, Putman, Brent, Pratt, Steve, Ma, Ji, Su, Zhi, Gopalakrishnan, Murali, Lee, Chih-Hung, McGaraughty, Steve P.

“…Adenosine (ADO) is an important regulatory purine nucleoside that accumulates at sites of inflammation and tissue injury including in diseases associated with…”
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Potentiation of analgesic efficacy but not side effects: Co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats by Zhu, Chang Z., Chin, Chih-liang, Rustay, Nathan R., Zhong, Chengmin, Mikusa, Joe, Chandran, Prasant, Salyers, Anita, Gomez, Erica, Simler, Gricelda, Lewis, La Geisha, Gauvin, Donna, Baker, Scott, Pai, Madhavi, Tovcimak, Ann, Brown, Jordan, Komater, Victoria, Fox, Gerard B., Decker, Michael W., Jacobson, Peer B., Gopalakrishnan, Murali, Lee, Chih-Hung, Honore, Prisca

“…Positive allosteric modulator NS-9283 enhances NNR α4β2 agonist ABT-594 (up to 100 nmol/kg)-induced analgesic efficacy in animal models of pain, and cortical…”
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