Search Results - "ZHOU, Yasheen"

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue by Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.

“…Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium…”
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Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors by Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Sullivan, David, Zhou, Yasheen, Zhang, Yong-Kang, Rock, Fernando, Freund, Yvonne, Liu, Liang, Bu, Wei, Wu, Anne, Fan, Xiao-Qing, Jarnagin, Kurt

“…Benzoxaboroles are a novel class of drug-like compounds that have been rich sources of novel inhibitors for various enzymes and of new drugs. While examining…”
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Chalcones and flavonoids as anti-tuberculosis agents by LIN, Yuh-Meei, YASHEEN ZHOU, FLAVIN, Michael T, ZHOU, Li-Ming, WEIGUO NIE, CHEN, Fa-Ching

“…A series of flavonoids, chalcones and chalcone-like compounds were evaluated for inhibitory activity against Mycobacterium tuberculosis H37Rv. Among them,…”
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Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide by Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jianxin, Zou, Wuxin

“…A novel series of isoxazoline benzoxaborole small molecules was designed and synthesized for a structure–activity relationship (SAR) investigation to assess…”
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Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles by Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Ye, Long, Zhou, Huchen, Waterson, David, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Zhiya, Li, Lingchao, Wang, Hailong, Cui, Han

“…A series of new boron-containing benzoxaborole compounds was designed and synthesized for a continuing structure–activity relationship (SAR) investigation…”
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Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease by Ding, Charles Z., Zhang, Yong-Kang, Li, Xianfeng, Liu, Yang, Zhang, Suoming, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Liu, Liang, Duan, Maosheng, Jarvest, Richard L., Ji, Jingjing, Kazmierski, Wieslaw M., Tallant, Matthew D., Wright, Lois L., Smith, Gary K., Crosby, Renae M., Wang, Amy A., Ni, Zhi-Jie, Zou, Wuxin, Wright, Jon

“…We disclose here a series of P4-benzoxaborole-substituted macrocyclic HCV protease inhibitors. These inhibitors are potent against HCV NS3 protease, their…”
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Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease by Duan, Maosheng, Kazmierski, Wieslaw, Crosby, Renae, Gartland, Margaret, Ji, Jinjing, Tallant, Matt, Wang, Amy, Hamatake, Robert, Wright, Lois, Wu, Min, Zhang, Yong-Kang, Ding, Charles Z., Li, Xianfeng, Liu, Yang, Zhang, Suoming, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J.

“…A novel series of P3 oxo-modified macrocyclic hepatitis C virus NS3/4A serine protease inhibitor was designed, synthesized and biologically evaluated. The…”
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Methylenedioxy- and ethylenedioxy-fused indolocarbazoles: potent human topoisomerase I inhibitors and antitumor agents by Zembower, David E, Xie, Yongping, Koohang, Ali, Kuffel, Mary J, Ames, Matthew M, Zhou, Yasheen, Mishra, Rama, Mar, Aye Aye, Flavin, Michael T, Xu, Ze-Qi

“…The indolo[2,3-a]carbazole alkaloids constitute an important class of natural products with interesting and diverse biological activities. A series of novel…”
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Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)­benzo[c][1,2]­oxaborol-1(3H)‑ol (GSK656) by Li, Xianfeng, Hernandez, Vincent, Rock, Fernando L, Choi, Wai, Mak, Yvonne S. L, Mohan, Manisha, Mao, Weimin, Zhou, Yasheen, Easom, Eric E, Plattner, Jacob J, Zou, Wuxin, Pérez-Herrán, Esther, Giordano, Ilaria, Mendoza-Losana, Alfonso, Alemparte, Carlos, Rullas, Joaquín, Angulo-Barturen, Iñigo, Crouch, Sabrinia, Ortega, Fátima, Barros, David, Alley, M. R. K

“…There is an urgent need to develop new and safer antitubercular agents that possess a novel mode of action. We synthesized and evaluated a novel series of…”
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Design and synthesis of highly constrained factor Xa inhibitors: amidine-Substituted bis(benzoyl)- [1,3]-diazepan-2-ones and bis(benzylidene)-bis( gem-dimethyl)cycloketones by Cui, Jian, Crich, David, Wink, Donald, Lam, Matthew, Rheingold, Arnold L, Case, David A, Fu, WenTao, Zhou, Yasheen, Rao, Mohan, Olson, Arthur J, Johnson, Michael E

“…Two conformationally constrained templates have been designed to provide selective inhibitors of the coagulation cascade serine protease, Factor Xa (FXa). The…”
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Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes by Dong, Chen, Virtucio, Charlotte, Zemska, Olga, Baltazar, Grober, Zhou, Yasheen, Baia, Diogo, Jones-Iatauro, Shannon, Sexton, Holly, Martin, Shamra, Dee, Joshua, Mak, Yvonne, Meewan, Maliwan, Rock, Fernando, Akama, Tsutomu, Jarnagin, Kurt

“…Psoriasis and atopic dermatitis are skin diseases affecting millions of patients. Here, we characterize benzoxaborole phosphodiesterase (PDE)-4 inhibitors, a…”
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Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase by Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z, Easom, Eric E, Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L, Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G, Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J, O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B, Waters, M Gerard, Ma, Zhenkun, Ioerger, Thomas R, Sacchettini, James C, Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J, Alley, M R K

“…The recent development and spread of extensively drug-resistant and totally drug-resistant resistant (TDR) strains of Mycobacterium tuberculosis highlight the…”
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Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center by Freund, Yvonne R., Akama, Tsutomu, Alley, M.R.K., Antunes, Joana, Dong, Chen, Jarnagin, Kurt, Kimura, Richard, Nieman, James A., Maples, Kirk R., Plattner, Jacob J., Rock, Fernando, Sharma, Rashmi, Singh, Rajeshwar, Sanders, Virginia, Zhou, Yasheen

“…► Novel boron-containing small molecule inhibitors of phosphodiesterase 4. ► Co-crystal structure shows unique binding compared to catechol inhibitors. ► Boron…”
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Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria by HERNANDEZ, Vincent, CREPIN, Thibaut, MEEWAN, Maliwan, MOHAN, Manisha, WEIMIN MAO, ROCK, Fernando L, SEXTON, Holly, SHEORAN, Anita, YANCHEN ZHANG, ZHANG, Yong-Kang, ZHOU, Yasheen, NIEMAN, James A, PALENCIA, Andrés, MAHIPAL REDDY ANUGULA, EL MEHDI KERAMANE, SAVARIRAJ, Kingsley, SHEKHAR REDDY, D, SHARMA, Rashmi, SUBEDI, Rajendra, SINGH, Rajeshwar, O'LEARY, Ann, SIMON, Nerissa L, DE MARSH, Peter L, CUSACK, Stephen, MUSHTAQ, Shazad, WARNER, Marina, LIVERMORE, David M, ALLEY, M. R. K, PLATTNER, Jacob J, AKAMA, Tsutomu, BAKER, Stephen J, WEI BU, LISA FENG, FREUND, Yvonne R, LIANG LIU

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides by Liu, Chunliang, Steere, Luke, McGregor, Cari, Frederick, Brittany H., Pastoor, Timothy, Zhou, Yasheen, Liu, C. Tony, Cai, Yan, Zhou, Haibo, Xu, Musheng, Wang, Jiangong, Kim, Sang Hu, Whitesell, Luke, Cowen, Leah E., Zhang, Yong-Kang

“…[Display omitted] Several boron-containing small molecules have been approved by the US FDA to treat human diseases. We explored potential applications of…”
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Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens by Kim, Sang Hu, Liu, Chunliang, Zhou, Yasheen, Zhang, Yong-Kang, McGregor, Cari, Steere, Luke, Frederick, Brittany H, Liu, C. Tony, Whitesell, Luke, Cowen, Leah E

“…Fungal pathogens pose an increasing threat to global food security through devastating effects on staple crops and contamination of food supplies with…”
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Inhibiting C‑4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens by Kim, Sang Hu, Steere, Luke, Zhang, Yong-Kang, McGregor, Cari, Hahne, Chris, Zhou, Yasheen, Liu, Chunliang, Cai, Yan, Zhou, Haibo, Chen, Xuefei, Puumala, Emily, Duncan, Dustin, Wright, Gerard D., Liu, C. Tony, Whitesell, Luke, Cowen, Leah E.

“…With resistance to current agricultural fungicides rising, a great need has emerged for new antifungals with unexploited targets. In response, we report a…”
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Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model by Robertson, Gregory T, Ektnitphong, Victoria A, Scherman, Michael S, McNeil, Matthew B, Dennison, Devon, Korkegian, Aaron, Smith, Anthony J, Halladay, Jason, Carter, David S, Xia, Yi, Zhou, Yasheen, Choi, Wai, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, Alley, M R K, Parish, Tanya, Lenaerts, Anne J

“…AN12855 is a direct, cofactor-independent inhibitor of InhA in In the C3HeB/FeJ mouse model with caseous necrotic lung lesions, AN12855 proved efficacious with…”
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The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis by Korkegian, Aaron, O'Malley, Theresa, Xia, Yi, Zhou, Yasheen, Carter, David S., Sunde, Bjorn, Flint, Lindsay, Thompson, Dean, Ioerger, Thomas R., Sacchettini, Jim, Alley, M.R.K., Parish, Tanya

“…We identified a series of novel 7-phenyl benzoxaborole compounds with activity against Mycobacterium tuberculosis. Compounds had a range of activity with…”
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AN2728, a new boron-based topical anti-inflammatory agent, inhibits phosphodiesterase 4 (IRC4P.611) by Freund, Yvonne, Dong, Chen, Virtucio-Frates, Charlotte, Rock, Fernando, Mak, Yvonne, Zhou, Yasheen, Zane, Lee, Jarnagin, Kurt

“…Abstract The novel boron-containing compound, AN2728, is being investigated in phase 3 trials for atopic dermatitis treatment. It exerts its anti-inflammatory…”
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