Search Results - "ZHOU, Xin J"

Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases by Hu, Ruimin, Quan, Songxia, Wang, Yingzi, Zhou, Yali, Zhang, Ying, Liu, Lu, Zhou, Xin J., Xing, Guolan

“…Chronic kidney diseases have become a major issue worldwide. The spectrum of biopsy proven renal diseases differs between locations and changes over time. It…”
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A Tlr7 Translocation Accelerates Systemic Autoimmunity in Murine Lupus by Subramanian, Srividya, Tus, Katalin, Li, Quan-Zhen, Wang, Andrew, Tian, Xiang-Hong, Zhou, Jinchun, Liang, Chaoying, Bartov, Guy, McDaniel, Lisa D., Zhou, Xin J., Schultz, Roger A., Wakeland, Edward K.

“…The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the…”
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Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury by Chen, Jianlin, John, Reji, Richardson, James A., Shelton, John M., Zhou, Xin J., Wang, Yanxia, Wu, Qing Qing, Hartono, John R., Winterberg, Pamela D., Lu, Christopher Y.

“…Ischemic acute kidney injury (AKI) triggers an inflammatory response which exacerbates injury that requires increased expression of endothelial adhesion…”
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Solidified glomerulosclerosis, identified using single glomerular proteomics, predicts end-stage renal disease in Chinese patients with type 2 diabetes by Zhao, Lijun, Liu, Fang, Li, Lin, Zhang, Junlin, Wang, Tingli, Zhang, Rui, Zhang, Wei, Yang, Xiaoyan, Zeng, Xiaoxi, Wang, Yiting, Wu, Yucheng, Yang, Hao, Wang, Shisheng, Zhong, Yi, Xu, Huan, Wang, Shanshan, Guo, Ruikun, Ren, Honghong, Yang, Lichuan, Su, Baihai, Zhang, Jie, Tong, Nanwei, Zhou, Xin J., Cooper, Mark E.

“…Few histological prognostic indicators for end-stage renal disease (ESRD) have been validated in diabetic patients. This biopsy-based study aimed to identify…”
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Heightened Crescentic Glomerulonephritis in Immune Challenged 129sv Mice Is TGF-β/Smad3 Dependent by Du, Yong, Xie, Chun, Ravikumar, Sneha, Orme, Jacob, Li, Li, Zhou, Xin J, Mohan, Chandra

“…The 129sv mouse strain is particularly sensitive to experimental immune-mediated nephritis. Previous studies have indicated that transforming growth factor-β…”
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Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis by Ye, Ting, Zhen, Junhui, Du, Yong, Zhou, Jason K, Peng, Ai, Vaziri, Nosratola D, Mohan, Chandra, Xu, Yan, Zhou, Xin J

“…Crescentic glomerulonephritis (GN) is the most severe form of GN and is associated with significant morbidity and mortality despite aggressive immunotherapy…”
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B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice by Hwang, Sun-Hee, Lee, Huiyin, Yamamoto, Miwako, Jones, Leigh A, Dayalan, Jivanaah, Hopkins, Richard, Zhou, Xin J, Yarovinsky, Felix, Connolly, John E, Curotto de Lafaille, Maria A, Wakeland, Edward K, Fairhurst, Anna-Marie

“…Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of antinuclear autoantibodies. Antinuclear…”
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Yaa autoimmune phenotypes are conferred by overexpression of TLR7 by Fairhurst, Anna-Marie, Hwang, Sun-hee, Wang, Andrew, Tian, Xiang-Hong, Boudreaux, Christopher, Zhou, Xin J, Casco, Jose, Li, Quan-Zhen, Connolly, John E, Wakeland, Edward K

“…The Y-linked autoimmune accelerating (Yaa) locus drives the transition to fatal lupus nephritis when combined with B6.Sle1 in our C57BL/6J (B6)-congenic model…”
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RNA sensing by conventional dendritic cells is central to the development of lupus nephritis by Celhar, Teja, Hopkins, Richard, Thornhill, Susannah I., De Magalhaes, Raquel, Hwang, Sun-Hee, Lee, Hui-Yin, Yasuga, Hiroko, Jones, Leigh A., Casco, Jose, Lee, Bernett, Thamboo, Thomas P., Zhou, Xin J., Poidinger, Michael, Connolly, John E., Wakeland, Edward K., Fairhurst, Anna-Marie

“…Glomerulonephritis is a common and debilitating feature of systemic lupus erythematosus (SLE). The precise immune mechanisms that drive the progression from…”
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Adverse effects of simulated hyper- and hypo-phosphatemia on endothelial cell function and viability by Peng, Ai, Wu, Tianfu, Zeng, Caihong, Rakheja, Dinesh, Zhu, Jiankun, Ye, Ting, Hutcheson, Jack, Vaziri, Nosratola D, Liu, Zhihong, Mohan, Chandra, Zhou, Xin J

“…Dysregulation of phosphate homeostasis as occurs in chronic kidney disease is associated with cardiovascular complications. It has been suggested that both…”
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Prevention of Murine Lupus Nephritis by Targeting Multiple Signaling Axes and Oxidative Stress Using a Synthetic Triterpenoid by Wu, Tianfu, Ye, Yujin, Min, So‐Youn, Zhu, Jiankun, Khobahy, Elhaum, Zhou, Jason, Yan, Mei, Hemachandran, Sriram, Pathak, Simanta, Zhou, Xin J., Andreeff, Michael, Mohan, Chandra

“…Objective Current treatment options for lupus are far from optimal. Previously, we reported that phosphatidylinositol 3‐kinase/Akt/mammalian target of…”
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Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus by Jacob, Chaim O, Zhu, Jiankun, Armstrong, Don L, Yan, Mei, Han, Jie, Zhou, Xin J, Thomas, James A, Reiff, Andreas, Myones, Barry L, Ojwang, Joshua O, Kaufman, Kenneth M, Klein-Gitelman, Marisa, McCurdy, Deborah, Wagner-Weiner, Linda, Silverman, Earl, Ziegler, Julie, Kelly, Jennifer A, Merrill, Joan T, Harley, John B, Ramsey-Goldman, Rosalind, Vila, Luis M, Bae, Sang-Cheol, Vyse, Timothy J, Gilkeson, Gary S, Gaffney, Patrick M, Moser, Kathy L, Langefeld, Carl D, Zidovetzki, Raphael, Mohan, Chandra

“…A combined forward and reverse genetic approach was undertaken to test the candidacy of IRAK1 (interleukin-1 receptor associated kinase-1) as an X…”
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Elevated Urinary VCAM-1, P-Selectin, Soluble TNF Receptor-1, and CXC Chemokine Ligand 16 in Multiple Murine Lupus Strains and Human Lupus Nephritis by Wu, Tianfu, Xie, Chun, Wang, Hong W, Zhou, Xin J, Schwartz, Noa, Calixto, Sergio, Mackay, Meggan, Aranow, Cynthia, Putterman, Chaim, Mohan, Chandra

“…In an effort to identify potential biomarkers in lupus nephritis, urine from mice with spontaneous lupus nephritis was screened for the presence of VCAM-1,…”
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Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury by Rauhauser, Alysha A, Ren, Chongyu, Lu, Dongmei, Li, Binghua, Zhu, Jili, McEnery, Kayla, Vadnagara, Komal, Zepeda-Orozco, Diana, Zhou, Xin J, Lin, Fangming, Jetten, Anton M, Attanasio, Massimo

“…Hedgehog (Hh) is an evolutionary conserved signaling pathway that has important functions in kidney morphogenesis and adult organ maintenance. Recent work has…”
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CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus by Wang, Andrew, Fairhurst, Anna-Marie, Tus, Katalin, Subramanian, Srividya, Liu, Yang, Lin, Fangming, Igarashi, Peter, Zhou, Xin J, Batteux, Frederic, Wong, Donald, Wakeland, Edward K, Mohan, Chandra

“…Among various surface molecules screened, CXCR4 was significantly up-regulated on monocytes, neutrophils, B cell subsets, and plasma cells in multiple murine…”
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Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury by Chen, Jianlin, Matzuk, Martin M, Zhou, Xin J, Lu, Christopher Y

“…Toll-like receptor 4 (TLR4), a receptor for damage-associated molecular pattern molecules and also the lipopolysaccharide receptor, is required for early…”
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Type I Interferons Produced by Resident Renal Cells May Promote End-Organ Disease in Autoantibody-Mediated Glomerulonephritis by Fairhurst, Anna-Marie, Xie, Chun, Fu, Yuyang, Wang, Andrew, Boudreaux, Christopher, Zhou, Xin J, Cibotti, Ricardo, Coyle, Anthony, Connolly, John E, Wakeland, Edward K, Mohan, Chandra

“…Increased Type I IFNs or IFN-I have been associated with human systemic lupus erythematosus. Interestingly augmenting or negating IFN-I activity in murine…”
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The green tea polyphenol (−)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis by Peng, Ai, Ye, Ting, Rakheja, Dinesh, Tu, Yangke, Wang, Tao, Du, Yong, Zhou, Jason K., Vaziri, Nosratola D., Hu, Zhao, Mohan, Chandra, Zhou, Xin J.

“…The unchecked overproduction of reactive oxygen and nitrogen species by inflammatory cells can cause tissue damage, intensify inflammation, promote apoptosis,…”
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Reliability of whole slide images as a diagnostic modality for renal allograft biopsies by Jen, Kuang-Yu, MD, PhD, Olson, Jean L., MD, Brodsky, Sergey, MD, Zhou, Xin J., MD, Nadasdy, Tibor, MD, PhD, Laszik, Zoltan G., MD, PhD

“…Summary The use of digital whole slide images (WSI) in the field of pathology has become feasible for routine diagnostic purposes and has become more prevalent…”
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Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress by Li, Yajuan, Raman, Indu, Du, Yong, Yan, Mei, Min, Soyoun, Yang, Jichen, Fang, Xiangdong, Li, Wei, Lu, Jianxin, Zhou, Xin J, Mohan, Chandra, Li, Quan-Zhen

“…Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal…”
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