Search Results - "ZHONGCONG XIE"

Perioperative Neurocognitive and Cardiovascular Disease by Xie, Zhongcong

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LncRNA Rik-203 contributes to anesthesia neurotoxicity via microRNA-101a-3p and GSK-3β-mediated neural differentiation by Zhang, Lei, Yan, Jia, Liu, Qidong, Xie, Zhongcong, Jiang, Hong

“…The mechanism of anesthesia neurotoxicity remains largely to be determined. The effects of long noncoding RNAs (LncRNAs) on neural differentiation and the…”
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Sevoflurane induces cognitive impairment in young mice via autophagy by Wang, Xiaoning, Dong, Yuanlin, Zhang, Yiying, Li, Tianzuo, Xie, Zhongcong

“…Anesthesia may induce neurotoxicity and neurocognitive impairment in young mice. However, the underlying mechanism remains largely to be determined. Meanwhile,…”
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Gut microbiota is critical for the induction of chemotherapy-induced pain by Shen, Shiqian, Lim, Grewo, You, Zerong, Ding, Weihua, Huang, Peigen, Ran, Chongzhao, Doheny, Jason, Caravan, Peter, Tate, Samuel, Hu, Kun, Kim, Hyangin, McCabe, Michael, Huang, Bo, Xie, Zhongcong, Kwon, Douglas, Chen, Lucy, Mao, Jianren

“…Recent evidence supports a functional connection between gut microbiota and the nervous system. Here the authors show that gut microbiota plays a critical role…”
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Neurotoxicity of general anesthetics: an update by Vlisides, Phillip, Xie, Zhongcong

“…Though general anesthetics have now been used clinically for well over a century, both their mechanisms of action as well as the nature of any potentially…”
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Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice by Yu, Yang, Yang, Yongyan, Tan, Hong, Boukhali, Myriam, Khatri, Ashok, Yu, Yonghao, Hua, Fuzhou, Liu, Ling, Li, Mengzhu, Yang, Guang, Dong, Yuanlin, Zhang, Yiying, Haas, Wilhelm, Xie, Zhongcong

“…BACKGROUND:Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment in neonatal but not in adult mice. This study tested the hypothesis that…”
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Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3β Activation in Young Mice by GUORONG TAO, JIE ZHANG, LEI ZHANG, YUANLIN DONG, BUWEI YU, CROSBY, Gregory, CULLEY, Deborah J, YIYING ZHANG, ZHONGCONG XIE

“…Children with multiple exposures to anesthesia and surgery may have an increased risk of developing cognitive impairment. Sevoflurane is a commonly used…”
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Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment by XIA SHEN, YUANLIN DONG, ZHIPENG XU, HUI WANG, CHANGHONG MIAO, SORIANO, Sulpicio G, DANDAN SUN, BAXTER, Mark G, YIYING ZHANG, ZHONGCONG XIE

“…: Recent population studies have suggested that children with multiple exposures to anesthesia and surgery at an early age are at an increased risk of…”
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Anesthesia and Surgery Impair Blood-Brain Barrier and Cognitive Function in Mice by Yang, Siming, Gu, Changping, Mandeville, Emiri T, Dong, Yuanlin, Esposito, Elga, Zhang, Yiying, Yang, Guang, Shen, Yuan, Fu, Xiaobing, Lo, Eng H, Xie, Zhongcong

“…Blood-brain barrier (BBB) dysfunction, e.g., increase in BBB permeability, has been reported to contribute to cognitive impairment. However, the effects of…”
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Anesthetic Sevoflurane Causes Neurotoxicity Differently in Neonatal Naïve and Alzheimer Disease Transgenic Mice by Lu, Yan, Wu, Xu, Dong, Yuanlin, Xu, Zhipeng, Zhang, Yiying, Xie, Zhongcong

“…Recent studies have suggested that children undergoing surgery under anesthesia could be at an increased risk for the development of learning disabilities, but…”
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Targeted metabolomics analysis of postoperative delirium by Tripp, Bridget A., Dillon, Simon T., Yuan, Min, Asara, John M., Vasunilashorn, Sarinnapha M., Fong, Tamara G., Metzger, Eran D., Inouye, Sharon K., Xie, Zhongcong, Ngo, Long H., Marcantonio, Edward R., Libermann, Towia A., Otu, Hasan H.

“…Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of delirium is poorly understood, and…”
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Battery of behavioral tests in mice to study postoperative delirium by Peng, Mian, Zhang, Ce, Dong, Yuanlin, Zhang, Yiying, Nakazawa, Harumasa, Kaneki, Masao, Zheng, Hui, Shen, Yuan, Marcantonio, Edward R., Xie, Zhongcong

“…Postoperative delirium is associated with increased morbidity, mortality and cost. However, its neuropathogenesis remains largely unknown, partially owing to…”
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Anesthetic Isoflurane Induces DNA Damage Through Oxidative Stress and p53 Pathway by Ni, Cheng, Li, Cheng, Dong, Yuanlin, Guo, Xiangyang, Zhang, Yiying, Xie, Zhongcong

“…DNA damage is associated with aging and neurological disorders, including Alzheimer’s disease. Isoflurane is a commonly used anesthetic. It remains largely…”
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Sevoflurane Induces a Cyclophilin D-Dependent Decrease of Neural Progenitor Cells Migration by Lu, Pan, Liang, Feng, Dong, Yuanlin, Xie, Zhongcong, Zhang, Yiying

“…Clinical studies have suggested that repeated exposure to anesthesia and surgery at a young age may increase the risk of cognitive impairment. Our previous…”
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Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory by Zhang, Yiying, Xu, Zhipeng, Wang, Hui, Dong, Yuanlin, Shi, Hai Ning, Culley, Deborah J., Crosby, Gregory, Marcantonio, Edward R., Tanzi, Rudolph E., Xie, Zhongcong

“…Objective: There are approximately 8.5 million Alzheimer disease (AD) patients who need anesthesia and surgery care every year. The inhalation anesthetic…”
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Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex by Zhao, Ruohe, Zhou, Hang, Huang, Lianyan, Xie, Zhongcong, Wang, Jing, Gan, Wen-Biao, Yang, Guang

“…The anterior cingulate cortex (ACC) is thought to be important for acute pain perception as well as the development of chronic pain after peripheral nerve…”
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Anesthesia, calcium homeostasis and Alzheimer's disease by Wei, Huafeng, Xie, Zhongcong

“…While anesthetics are indispensable clinical tools generally safe and effective, in some situations there is grown concern about selective neurotoxicity of…”
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Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation by Dong, Yuanlin, Wu, Xu, Xu, Zhipeng, Zhang, Yiying, Xie, Zhongcong

“…Anesthetic isoflurane has been shown to promote Alzheimer's disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ)…”
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Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice by Wang, Xueqin, Song, Yaying, Chen, Jie, Zhang, Shuibing, Le, Yuan, Xie, Zhongcong, Ouyang, Wen, Tong, Jianbin

“…Post-sepsis cognitive impairment is one of the major sequelae in sepsis survivors. Its prevention remains clinically challenging. Here we tested the effects…”
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Sevoflurane increases locomotion activity in mice by Ton, Hoai T, Yang, Lei, Xie, Zhongcong

“…Clinical observations show emergence of agitation and hyperactivity during the anesthesia induction and/or recovery period post-anesthesia. However, an animal…”
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