Search Results - "ZHIYOU FANG"

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate by Hu, Lei, Chen, Meng, Chen, Xueran, Zhao, Chenggang, Fang, Zhiyou, Wang, Hongzhi, Dai, Haiming

“…Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer…”
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EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression by Chen, Xueran, Ma, Huihui, Wang, Zhen, Zhang, Shangrong, Yang, Haoran, Fang, Zhiyou

“…Gliomas with mutant p53 occurring in 30% of glioma patients exhibit therapeutic resistance and poor outcomes. In this study, we identify a novel mechanism…”
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Author Correction: Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate by Hu, Lei, Chen, Meng, Chen, Xueran, Zhao, Chenggang, Fang, Zhiyou, Wang, Hongzhi, Dai, Haiming

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Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation by Fan, Xiaoqing, Fan, Junqi, Yang, Haoran, Zhao, Chenggang, Niu, Wanxiang, Fang, Zhiyou, Chen, Xueran

“…Glioblastoma (GBM) is the most common and deadly of the primary intracranial tumors and is comprised of subsets that show plasticity and marked heterogeneity,…”
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Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma by Li, Shuyang, Wang, Wei, Yu, Huihan, Zhang, Siyu, Bi, Wenxu, Sun, Suling, Hong, Bo, Fang, Zhiyou, Chen, Xueran

“…Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death worldwide. Its…”
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Specific glioblastoma multiforme prognostic-subtype distinctions based on DNA methylation patterns by Ma, Huihui, Zhao, Chenggang, Zhao, Zhiyang, Hu, Lizhu, Ye, Fang, Wang, Hongzhi, Fang, Zhiyou, Wu, Yuejin, Chen, Xueran

“…DNA methylation is an important regulator of gene expression, and plays a significant role in carcinogenesis in the brain. Here, we explored specific…”
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DHHC protein family targets different subsets of glioma stem cells in specific niches by Chen, Xueran, Hu, Lei, Yang, Haoran, Ma, Huihui, Ye, Kaiqin, Zhao, Chenggang, Zhao, Zhiyang, Dai, Haiming, Wang, Hongzhi, Fang, Zhiyou

“…Glioblastomas (GBM) comprise different subsets that exhibit marked heterogeneity and plasticity, leading to a lack of success of genomic profiling in guiding…”
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Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation by Fan, Xiaoqing, Yang, Haoran, Zhao, Chenggang, Hu, Lizhu, Wang, Delong, Wang, Ruiting, Fang, Zhiyou, Chen, Xueran

“…A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell…”
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Specific Glioma Prognostic Subtype Distinctions Based on DNA Methylation Patterns by Chen, Xueran, Zhao, Chenggang, Zhao, Zhiyang, Wang, Hongzhi, Fang, Zhiyou

“…DNA methylation is an important regulator of gene expression and may provide an important basis for effective glioma diagnosis and therapy. Here, we explored…”
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Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc by Bian, Erbao, Chen, Xueran, Cheng, Li, Cheng, Meng, Chen, Zhigang, Yue, Xiaoyu, Zhang, Zhengwei, Chen, Jie, Sun, Libo, Huang, Kebing, Huang, Cheng, Fang, Zhiyou, Zhao, Bing, Li, Jun

“…Long non-coding RNAs (lncRNAs) have been considered as one type of gene expression regulator for cancer development, but it is not clear how these are…”
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GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis by Zhao, Chenggang, Yu, Huihan, Fan, Xiaoqing, Niu, Wanxiang, Fan, Junqi, Sun, Suling, Gong, Meiting, Zhao, Bing, Fang, Zhiyou, Chen, Xueran

“…Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered a key hub for…”
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Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway by Chen, Xueran, Zhang, Shangrong, Wang, Zhen, Wang, Fengsong, Cao, Xinwang, Wu, Quan, Zhao, Chenggang, Ma, Huihui, Ye, Fang, Wang, Hongzhi, Fang, Zhiyou

“…Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with HCC…”
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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation by Zhang, Ting, Liu, Shuaiyu, Durojaye, Olanrewaju, Xiong, Fangyuan, Fang, Zhiyou, Ullah, Tahir, Fu, Chuanhai, Sun, Bo, Jiang, Hao, Xia, Peng, Wang, Zhikai, Yao, Xuebiao, Liu, Xing

“…FOXA1 serves as a crucial pioneer transcription factor during developmental processes and plays a pivotal role as a mitotic bookmarking factor to perpetuate…”
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Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression by Chen, Zhigang, Tian, Dasheng, Chen, Xueran, Cheng, Meng, Xie, Han, Zhao, JiaJia, Liu, Jun, Fang, Zhiyou, Zhao, Bing, Bian, Erbao

“…Long non-coding RNAs (lncRNAs) are tissue-specific expression patterns and dysregulated in cancer. How they are regulated still needs to be determined. We…”
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The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission by He, Jiajia, Liu, Ke, Wu, Yifan, Zhao, Chenhui, Yan, Shuaijie, Chen, Jia-Hui, Hu, Lizhu, Wang, Dongmei, Zheng, Fan, Wei, Wenfan, Xu, Chao, Huang, Chengdong, Liu, Xing, Yao, Xuebiao, Ding, Lijun, Fang, Zhiyou, Tang, Ai-Hui, Fu, Chuanhai

“…Mitochondria are in a constant balance of fusion and fission. Excessive fission or deficient fusion leads to mitochondrial fragmentation, causing mitochondrial…”
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Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer by Liu, Dongyan, Hou, Xiaonan, Wu, Wangyu, Zanfagnin, Valentina, Li, Yunjian, Correia, Cristina, Zhao, Zhiyang, Zhao, Chenggang, Liu, Zhirong, Zhang, Tao, Fang, Zhiyou, Wang, Hongzhi, Xu, Chao, Weroha, Saravut J., Kaufmann, Scott H., Dai, Haiming

“…We previously found that preformed complexes of BAK with antiapoptotic BCL2 proteins predict BH3 mimetic sensitivities in lymphohematopoietic cells. These…”
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Systematic Profiling of Alternative mRNA Splicing Signature for Predicting Glioblastoma Prognosis by Chen, Xueran, Zhao, Chenggang, Guo, Bing, Zhao, Zhiyang, Wang, Hongzhi, Fang, Zhiyou

“…Emerging evidence suggests that alternative splicing (AS) is modified in cancer and is associated with cancer progression. Systematic analysis of AS signature…”
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Correction: Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation by Fan, Xiaoqing, Fan, Junqi, Yang, Haoran, Zhao, Chenggang, Niu, Wanxiang, Fang, Zhiyou, Chen, Xueran

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Systematic transcriptome profiling of pyroptosis related signature for predicting prognosis and immune landscape in lower grade glioma by Yu, Huihan, Gong, Meiting, Qi, Jian, Zhao, Chenggang, Niu, Wanxiang, Sun, Suling, Li, Shuyang, Hong, Bo, Qian, Junchao, Wang, Hongzhi, Chen, Xueran, Fang, Zhiyou

“…Background Pyroptosis is a programmed cell death mediated by the gasdermin superfamily, accompanied by inflammatory and immune responses. Exogenously activated…”
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Correction: Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer by Liu, Dongyan, Hou, Xiaonan, Wu, Wangyu, Zafagnin, Valentina, Li, Yunjian, Correia, Cristina, Zhao, Zhiyang, Zhao, Chenggang, Liu, Zhirong, Zhang, Tao, Fang, Zhiyou, Wang, Hongzhi, Xu, Chao, Weroha, Saravut J., Kaufmann, Scott H., Dai, Haiming

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