Search Results - "ZHIGANG HONG"

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury by Huang, Long Shuang, Hong, Zhigang, Wu, Wei, Xiong, Shiqin, Zhong, Ming, Gao, Xiaopei, Rehman, Jalees, Malik, Asrar B.

“…Cytosolic DNA acts as a universal danger-associated molecular pattern (DAMP) signal; however, the mechanisms of self-DNA release into the cytosol and its role…”
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The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation by Di, Anke, Xiong, Shiqin, Ye, Zhiming, Malireddi, R.K. Subbarao, Kometani, Satoshi, Zhong, Ming, Mittal, Manish, Hong, Zhigang, Kanneganti, Thirumala-Devi, Rehman, Jalees, Malik, Asrar B.

“…Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the…”
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Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions by Friedrich, Emily E., Hong, Zhigang, Xiong, Shiqin, Zhong, Ming, Di, Anke, Rehman, Jalees, Komarova, Yulia A., Malik, Asrar B.

“…Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or high altitude can lead to endothelial barrier disruption referred…”
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Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury by Cheng, Kwong Tai, Xiong, Shiqin, Ye, Zhiming, Hong, Zhigang, Di, Anke, Tsang, Kit Man, Gao, Xiaopei, An, Shejuan, Mittal, Manish, Vogel, Stephen M, Miao, Edward A, Rehman, Jalees, Malik, Asrar B

“…Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale destruction of the lung endothelial barrier, which results in…”
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Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation by Jambusaria, Ankit, Hong, Zhigang, Zhang, Lianghui, Srivastava, Shubhi, Jana, Arundhati, Toth, Peter T, Dai, Yang, Malik, Asrar B, Rehman, Jalees

“…Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but little is known about their characteristic gene expression…”
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Dynamin‐related protein 1 (Drp1)‐mediated diastolic dysfunction in myocardial ischemia‐reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission by Sharp, Willard W., Fang, Yong Hu, Han, Mei, Zhang, Hannah J., Hong, Zhigang, Banathy, Alexandra, Morrow, Erik, Ryan, John J., Archer, Stephen L.

“…Mitochondrial fission, regulated by dynamin‐related protein‐1 (Drp1), is a newly recognized determinant of mitochondrial function, but its contribution to left…”
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Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer by Rehman, Jalees, Zhang, Hannah J., Toth, Peter T., Zhang, Yanmin, Marsboom, Glenn, Hong, Zhigang, Salgia, Ravi, Husain, Aliya N., Wietholt, Christian, Archer, Stephen L.

“…Mitochondria exist in dynamic networks that undergo fusion and fission. Mitochondrial fusion and fission are mediated by several GTPases in the outer…”
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SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress by Samant, Sadhana A., Zhang, Hannah J., Hong, Zhigang, Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Wolfgeher, Donald, Archer, Stephen L., Chan, David C., Gupta, Mahesh P.

“…Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype by Hong, Zhigang, Chen, Kuang-Hueih, DasGupta, Asish, Potus, Francois, Dunham-Snary, Kimberly, Bonnet, Sebastien, Tian, Lian, Fu, Jennifer, Breuils-Bonnet, Sandra, Provencher, Steeve, Wu, Danchen, Mewburn, Jeffrey, Ormiston, Mark L, Archer, Stephen L

“…Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation,…”
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The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury by Zhou, Bisheng, Magana, Lissette, Hong, Zhigang, Huang, Long Shuang, Chakraborty, Sreeparna, Tsukasaki, Yoshikazu, Huang, Cary, Wang, Li, Di, Anke, Ganesh, Balaji, Gao, Xiaopei, Rehman, Jalees, Malik, Asrar B.

“…Macrophages demonstrate remarkable plasticity that is essential for host defense and tissue repair. The tissue niche imprints macrophage identity, phenotype…”
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Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension by Marsboom, Glenn, Toth, Peter T, Ryan, John J, Hong, Zhigang, Wu, Xichen, Fang, Yong-Hu, Thenappan, Thenappan, Piao, Lin, Zhang, Hannah J, Pogoriler, Jennifer, Chen, Yimei, Morrow, Erik, Weir, E Kenneth, Rehman, Jalees, Archer, Stephen L

“…RATIONALE:Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by pulmonary vascular obstruction caused, in part, by pulmonary artery…”
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PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension by RYAN, John J, MARSBOOM, Glenn, MEI HAN, HANEY, Chad R, CHEN, Chin-Tu, SHARP, Willard W, ARCHER, Stephen L, FANG, Yong-Hu, TOTH, Peter T, MORROW, Erik, LUO, Nancy, LIN PIAO, ZHIGANG HONG, ERICSON, Kyle, ZHANG, Hannah J

“…Pulmonary arterial hypertension (PAH) is a lethal, female-predominant, vascular disease. Pathologic changes in PA smooth muscle cells (PASMC) include excessive…”
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Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle by Fang, Yong-Hu, Piao, Lin, Hong, Zhigang, Toth, Peter T., Marsboom, Glenn, Bache-Wiig, Peter, Rehman, Jalees, Archer, Stephen L.

“…Right ventricular hypertrophy (RVH) and RV failure are major determinants of prognosis in pulmonary hypertension and congenital heart disease. In RVH, there is…”
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Lymphovascular invasion represents a superior prognostic and predictive pathological factor of the duration of adjuvant chemotherapy for stage III colon cancer patients by Zhang, Linjie, Deng, Yuxiang, Liu, Songran, Zhang, Weili, Hong, Zhigang, Lu, Zhenhai, Pan, Zhizhong, Wu, Xiaojun, Peng, Jianhong

“…Lymphovascular invasion (LVI) and perineural invasion (PNI) can indicate poor survival outcomes in colorectal cancer, but few studies have focused on stage III…”
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N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability by Kruse, Kevin, Lee, Quinn S, Sun, Ying, Klomp, Jeff, Yang, Xiaoyan, Huang, Fei, Sun, Mitchell Y, Zhao, Shuangping, Hong, Zhigang, Vogel, Stephen M, Shin, Jae-Won, Leckband, Deborah E, Tai, Leon M, Malik, Asrar B, Komarova, Yulia A

“…Vascular endothelial (VE)-cadherin forms homotypic adherens junctions (AJs) in the endothelium, whereas N-cadherin forms heterotypic adhesion between…”
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IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury by Xiong, Shiqin, Hong, Zhigang, Huang, Long Shuang, Tsukasaki, Yoshikazu, Nepal, Saroj, Di, Anke, Zhong, Ming, Wu, Wei, Ye, Zhiming, Gao, Xiaopei, Rao, Gadiparthi N, Mehta, Dolly, Rehman, Jalees, Malik, Asrar B

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The effects of oxaliplatin-based adjuvant chemotherapy in high-risk stage II colon cancer with mismatch repair-deficient: a retrospective study by Liao, Leen, Tang, Jinghua, Hong, Zhigang, Jiang, Wu, Li, Yuan, Kong, Lingheng, Han, Kai, Hou, Zhenlin, Zhang, Chenzhi, Zhou, Chi, Zhang, Linjie, Sui, Qiaoqi, Xiao, Binyi, Mei, Weijian, Yu, Jiehai, Yang, Wanjun, Pan, Zhizhong, Ding, Pei-Rong

“…For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim of this study…”
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A computational approach to identify cellular heterogeneity and tissue-specific gene regulatory networks by Jambusaria, Ankit, Klomp, Jeff, Hong, Zhigang, Rafii, Shahin, Dai, Yang, Malik, Asrar B, Rehman, Jalees

“…The heterogeneity of cells across tissue types represents a major challenge for studying biological mechanisms as well as for therapeutic targeting of distinct…”
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Role of Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus by Hong, Zhigang, Kutty, Shelby, Toth, Peter T, Marsboom, Glenn, Hammel, James M, Chamberlain, Carolyn, Ryan, John J, Zhang, Hannah J, Sharp, Willard W, Morrow, Erik, Trivedi, Kalyani, Weir, E Kenneth, Archer, Stephen L

“…RATIONALE:Closure of the ductus arteriosus (DA) is essential for the transition from fetal to neonatal patterns of circulation. Initial PO2-dependent…”
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Research Overview on Unconventional Pollutant Detection and Cooperative Control Technology of Flue Gas in Coal-fired Power Plant by Zhigang HONG, Yang ZHANG, Yongsheng LIU, Yue ZHU

“…With the continuous improvement of national environmental protection requirements, in response to the call of national sustainable development policy, the…”
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