Search Results - "ZHENGSHENG YAO"

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer by Zhang, Meili, Yao, Zhengsheng, Dubois, Sigrid, Ju, Wei, Müller, Jürgen R, Waldmann, Thomas A

“…IL-15 has potential as an immunotherapeutic agent for cancer treatment because it is a critical factor for the proliferation and activation of natural killer…”
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Combined-modality radioimmunotherapy : synergistic effect of paclitaxel and additive effect of bevacizumab by Jang, Beom-Su, Lee, Sang-Myung, Kim, Hyung Sub, Shin, In Soo, Razjouyan, Faezeh, Wang, Shutao, Yao, Zhengsheng, Pastan, Ira, Dreher, Matthew R, Paik, Chang H

“…Abstract Introduction This study was undertaken to investigate the effect of paclitaxel and bevacizumab on the therapeutic efficacy of90 Y-labeled B3…”
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Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the α-emitting radionuclide, bismuth 213 by Zhang, Meili, Yao, Zhengsheng, Garmestani, Kayhan, Axworthy, Donald B., Zhang, Zhuo, Mallett, Robert W., Theodore, Louis J., Goldman, Carolyn K., Brechbiel, Martin W., Carrasquillo, Jorge A., Waldmann, Thomas A.

“…We used a pretargeting technique to treat a nonobese diabetic/severe combined immunodeficient murine model of human adult T-cell leukemia with an anti-Tac…”
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Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors by Zhang, Meili, Yao, Zhengsheng, Zhang, Zhuo, Garmestani, Kayhan, Goldman, Carolyn K., Ravetch, Jeffrey V., Janik, John, Brechbiel, Martin W., Waldmann, Thomas A.

“…CD30 is a member of the tumor necrosis factor receptor family. Overexpression of CD30 on some neoplasms versus its limited expression on normal tissues makes…”
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Effective Therapy of Murine Models of Human Leukemia and Lymphoma with Radiolabeled Anti-CD30 Antibody, HeFi-1 by Zhang, Meili, Yao, Zhengsheng, Patel, Hiral, Garmestani, Kayhan, Zhang, Zhuo, Talanov, Vladimir S., Plascjak, Paul S., Goldman, Carolyn K., Janik, John E., Brechbiel, Martin W., Waldmann, Thomas A.

“…CD30 is a member of the TNF receptor superfamily. Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a…”
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Effect of albumin fusion on the biodistribution of interleukin-2 by ZHENGSHENG YAO, WEILI DAI, PERRY, James, BRECHBIEL, Martin W, SUNG, Cynthia

“…We investigated and compared the biodistribution of Albuleukin, a human serum albumin (HSA)-interleukin-2 (IL-2) fusion protein, with those of IL-2 and HSA…”
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Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody by Shin, In Soo, Lee, Sang-Myung, Kim, Hyung Sub, Yao, Zhengsheng, Regino, Celeste, Sato, Noriko, Cheng, Kenneth T., Hassan, Raffit, Campo, Melissa F., Albone, Earl F., Choyke, Peter L., Pastan, Ira, Paik, Chang H.

“…Radiolabeling of a monoclonal antibody (mAb) with a metallic radionuclide requires the conjugation of a bifunctional chelator to the mAb. The conjugation,…”
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Effect of Molecular Size of Pegylated Peptide on the Pharmacokinetics and Tumor Targeting in Lymphoma-Bearing Mice by DeNardo, Sally J, Yao, Zhengsheng, Lam, Kit S, Song, Aimin, Burke, Patricia A, Mirick, Gary R, Lamborn, Kathleen R, O'Donnell, Robert T, DeNardo, Gerald L

“…Purpose: Rapid blood and body clearances have hampered effective tumor targeting by small molecules. We used branched poly(ethylene glycol) (pegylated)…”
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Comparative Cellular Catabolism and Retention of Astatine-, Bismuth-, and Lead-Radiolabeled Internalizing Monoclonal Antibody by Yao, Zhengsheng, Garmestani, Kayhan, Wong, Karen J, Park, Luke S, Dadachova, Ekaterina, Yordanov, Alexander, Waldmann, Thomas A, Eckelman, William C, Paik, Chang H, Carrasquillo, Jorge A

“…Monoclonal antibodies (mAbs) labeled with alpha-emitting radionuclides such as (211)At, (212)Bi, (213)Bi, and (212)Pb (which decays by beta-emission to its…”
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The anti-CD25 monoclonal antibody 7G7/B6, armed with the α-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia by MEILI ZHANG, ZHENGSHENG YAO, BRECHBIEL, Martin W, CARRASQUILLO, Jorge A, WALDMANN, Thomas A, ZHUO ZHANG, GARMESTANI, Kayhan, TALANOV, Vladimir S, PLASCJAK, Paul S, YU, Sarah, KIM, Hyung-Sik, GOLDMAN, Carolyn K, PAIK, Chang H

“…Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. alpha-Particles are very attractive for cancer therapy, especially for isolated…”
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IL-15 enhanced antibody-dependent cellular cytotoxicity mediated by NK cells and macrophages by Zhang, Meili, Wen, Bernard, Anton, Olga M., Yao, Zhengsheng, Dubois, Sigrid, Ju, Wei, Sato, Noriko, DiLillo, David J., Bamford, Richard N., Ravetch, Jeffrey V., Waldmann, Thomas A.

“…The goal of cancer immunotherapy is to stimulate the host immune system to attack malignant cells. Antibody-dependent cellular cytotoxicity (ADCC) is a pivotal…”
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The Relationship of Glycosylation and Isoelectric Point with Tumor Accumulation of Avidin by Yao, Zhengsheng, Zhang, Meili, Sakahara, Harumi, Nakamoto, Yuji, Higashi, Tatsuya, Zhao, Songji, Sato, Noriko, Arano, Yasushi, Konishi, Junji

“…Radiolabeled avidin markedly accumulated in intraperitoneal tumors and was cleared rapidly from circulation when given intraperitoneally. This study…”
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Pretargeted α Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid-Biotin by ZHENGSHENG YAO, MEILI ZHANG, PASTAN, Ira, PAIK, Chang H, BRECHBIEL, Martin W, CARRASQUILLO, Jorge A, GARMESTANI, Kayhan, AXWORTHY, Donald B, MALLETT, Robert W, FRITZBERG, Alan R, THEODORE, Lou J, PLASCJAK, Paul S, ECKELMAN, William C, WALDMANN, Thomas A

“…Purpose: The use of an α emitter for radioimmunotherapy has potential advantages compared with β emitters. When administered systemically optimal targeting of…”
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Intratumoral Distribution of Radiolabeled Antibody and Radioimmunotherapy in Experimental Liver Metastases Model of Nude Mouse by Sato, Noriko, Saga, Tsuneo, Sakahara, Harumi, Yao, Zhengsheng, Nakamoto, Yuji, Zhang, Meili, Kuroki, Masahide, Matsuoka, Yuji, Iida, Yasuhiko, Konishi, Junji

“…The biodistribution and intratumoral distribution of radiolabeled anticarcinoembryonic antigen (CEA) monoclonal antibody in experimental liver metastases and…”
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Tumor targeting properties of two monoclonal antibodies directed against two different antigens, shed and non-shed, expressed on the same tumor by Lee, Jae-Ho, Kim, Heejung, Yao, Zhengsheng, Kim, Insook, Szajek, Lawrence, Grasso, Luigi, Pastan, Ira, Paik, Chang

“…Objectives: To investigate key parameters to improve the tumor delivery and penetration. We performed biodistribution (BD), PET imaging and autoradiography…”
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Improved renal clearance and tumor targeting of 99mTc-labeled anti-Tac monoclonal antibody Fab by chemical modifications by KIM, Meyoung-Kon, JEONG, Hyeh-Jean, KAO, Chih-Hao K, ZHENGSHENG YAO, PAIK, David S, JAE EUN PIE, KOBAYASHI, Hisataka, WALDMANN, Thomas A, CARRASQUILLO, Jorge A, PAIK, Chang H

“…This study was undertaken to improve the renal clearance and tumor targeting properties of 99mTc-labeled humanized anti-Tac (HuTac) monoclonal antibody Fab…”
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Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice by Zhang, Meili, Ju, Wei, Yao, Zhengsheng, Yu, Ping, Wei, Bih-Rong, Simpson, R Mark, Waitz, Rebecca, Fassò, Marcella, Allison, James P, Waldmann, Thomas A

“…IL-15 has potential as an immunotherapeutic agent for cancer treatment because it is a critical factor for the proliferation and activation of NK and CD8(+) T…”
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Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two 89 Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens by Lee, Jae-Ho, Kim, Heejung, Yao, Zhengsheng, Szajek, Lawrence P., Grasso, Luigi, Kim, Insook, Paik, Chang H.

“…We investigated the effect of shed antigen mesothelin on the tumor uptake of amatuximab, a therapeutic anti-mesothelin mAb clinically tested in mesothelioma…”
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Tumor and organ uptake of (64)Cu-labeled MORAb-009 (amatuximab), an anti-mesothelin antibody, by PET imaging and biodistribution studies by Lee, Jae-Ho, Kim, Heejung, Yao, Zhengsheng, Lee, Sung-Jin, Szajek, Lawrence P, Grasso, Luigi, Pastan, Ira, Paik, Chang H

“…To investigate the effect of the injection dose of MORAb-009 (amatuximab, an anti-mesothelin monoclonal antibody), the tumor size and the level of shed…”
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Anti‐murine Antibody Response to Mouse Monoclonal Antibodies in Cancer Patients by Sakahara, Harumi, Saga, Tsuneo, Onodera, Hisashi, Yao, Zhengsheng, Nakamoto, Yuji, Zhang, Meili, Sato, Noriko, Nakada, Hiroshi, Yamashina, Ikuo, Endo, Keigo, Konishi, Junji

“…Although development of human anti‐murine inununoglobulin antibody (HAMA) is often seen in patients receiving murine antibodies, the variety of methods used…”
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