Search Results - "ZHENG, XUEXIU"

The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing by Shen, Haihong, Zheng, Xuexiu, Luecke, Stephan, Green, Michael R

“…The U2AF35-related protein Urp has been implicated previously in splicing of the major class of U2-type introns. Here we show that Urp is also required for…”
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Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA by Choi, Namjeong, Liu, Yongchao, Oh, Jagyeong, Ha, Jiyeon, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5’ splice-site selection…”
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Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome by Shen, Haihong, Zheng, Xuexiu, Shen, Jingping, Zhang, Lingdi, Zhao, Rui, Green, Michael R

“…The essential splicing factor human UAP56 (hUAP56) is a DExD/H-box protein known to promote prespliceosome assembly. Here, using a series of hUAP56 mutants…”
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hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7 by Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Huyn Kyung, Cho, Sungchan, Choy, Hyon E., Song, Woo Keun, Chun, Jang-Soo, Zheng, Xuexiu, Shen, Haihong

“…Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease, which causes death of motor neurons in the anterior horn of the spinal cord. Genetic…”
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U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing by Choi, Namjeong, Liu, Yongchao, Oh, Jagyeong, Ha, Jiyeon, Zheng, Xuexiu, Shen, Haihong

“…Splicing factor 3b subunit 1 (SF3B1) is an essential protein in spliceosomes and mutated frequently in many cancers. While roles of SF3B1 in single intron…”
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hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3' Splice Sites by Liu, Yongchao, Kim, Donggun, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zhou, Jianhua, Zheng, Xuexiu, Shen, Haihong

“…The ratio control of 4R-Tau/3R-Tau by alternative splicing of Tau exon 10 is important for maintaining brain functions. In this study, we show that hnRNP A1…”
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Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells by Oh, Jagyeong, Pradella, Davide, Shao, Changwei, Li, Hairi, Choi, Namjeong, Ha, Jiyeon, Ruggiero, Sonia, Fu, Xiang-Dong, Zheng, Xuexiu, Ghigna, Claudia, Shen, Haihong

“…Aberrant alternative splicing (AS) is a hallmark of cancer and a potential target for novel anti-cancer therapeutics. Breast cancer-associated AS events are…”
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PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion by Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Hyun Kyung, Williams, Darren Reese, Liao, D. Joshua, Zhou, Jianhua, Green, Michael R., Zheng, Xuexiu, Shen, Haihong

“…Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease and a leading cause of infant mortality. Deletions or mutations of SMN1 cause SMA, a…”
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SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon by Ha, Jiyeon, Jang, Hana, Choi, Namjeong, Oh, Jagyeong, Min, Chanhyuk, Pradella, Davide, Jung, Da-Woon, Williams, Darren R, Park, Daeho, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Alternative splicing (AS) is an important posttranscriptional regulatory process. Damaged or unnecessary cells need to be removed though apoptosis to maintain…”
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Activation of Cryptic 3' Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping by Moon, Heegyum, Jang, Ha Na, Liu, Yongchao, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zheng, Xuexiu, Shen, Haihong

“…Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival…”
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Splicing inhibition of U2AF65 leads to alternative exon skipping by Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Jang, Ha Na, Liu, Yongchao, Zhou, Jianhua, Ohn, Takbum, Zheng, Xuexiu, Shen, Haihong

“…U2 snRNP auxiliary factor 65 kDa (U2AF(65)) is a general splicing factor that contacts polypyrimidine (Py) tract and promotes prespliceosome assembly. In this…”
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RNAi-based Analysis of CAP, Cbl, and CrkII Function in the Regulation of GLUT4 by Insulin by Mitra, Prasenjit, Zheng, Xuexiu, Czech, Michael P.

“…Stimulation of glucose transport by insulin in cultured adipocytes through translocation of intracellular GLUT4 glucose transporters to the plasma membrane has…”
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Chimeric RNAs as potential biomarkers for tumor diagnosis by Zhou, Jianhua, Liao, Joshua, Zheng, Xuexiu, Shen, Haihong

“…Cancers claim millions of lives each year. Early detection that can enable a higher chance of cure is of paramount importance to cancer patients. However,…”
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Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA by Choi, Namjeong, Liu, Yongchao, Oh, Jagyeong, Ha, Jiyeon, Ghigna, Claudia, Zheng, Xuexiu, Shen, Haihong

“…Bcl-x, a member of the Bcl-2 family, plays a key role in apoptosis. Alternative splicing of Bcl-x pre-mRNA through alternative 5’ splice-site selection…”
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Targeting RNA-Splicing for SMA Treatment by Zhou, Jianhua, Nantong University, JiangSu, P. R. China, Zheng, Xuexiu, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea, Shen, Haihong, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

“…The central dogma of DNA-RNA-protein was established more than 40 years ago. However, important biological processes have been identified since the central…”
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Identification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene by Moon, Heegyum, Zheng, Xuexiu, Loh, Tiing Jen, Jang, Ha Na, Liu, Yongchao, Jung, Da-Woon, Williams, Darren R, Shen, Haihong

“…RON receptor tyrosine kinase is a proto-oncogene that induces cell migration and matrix invasion. RONΔ160 protein, which is produced by exclusion of exon 5 and…”
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Identification of novel splicing variants from RON proto-oncogene pre-mRNA by MOON, HEEGYUM, CHO, SUNGHEE, YANG, XIAOMING, ZHOU, JIANHUA, LOH, TIING JEN, ZHENG, XUEXIU, SHEN, HAIHONG

“…RON is a proto-oncogene that induces cell dissociation, migration and matrix invasion. RONΔ160, a splicing variant of RON, is a natural splicing product in…”
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RRM but not the Asp/Glu domain of hnRNP C 1 /C 2 is required for splicing regulation of Ron exon 11 pre-mRNA by Moon, Heegyum, Jang, Ha Na, Liu, Yongchao, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Kim, Hyeon Ho, Zheng, Xuexiu, Shen, Haihong

“…The Ron proto-oncogene is a human receptor for macrophage-stimulating protein (MSP). The exclusion of exon 11 in alternative splicing generates △RON protein…”
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3′ Splice Site Sequences of Spinal Muscular Atrophy Related SMN2 Pre-mRNA Include Enhancers for Nearby Exons by Shen, Haihong, Zheng, Xuexiu, Liao, D. Joshua, Shin, Myung-Geun, Kim, Hye-Ran, Oh, Hyun Kyung, Loh, Tiing Jen, Moon, Heegyum, Cho, Sunghee, Zhou, Jianhua

“…Spinal muscular atrophy (SMA) is a human genetic disease which occurs because of the deletion or mutation of SMN1 gene. SMN1 gene encodes the SMN protein which…”
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CRISPR as a strong gene editing tool by Shen, Shengfu, Loh, Tiing Jen, Shen, Hongling, Zheng, Xuexiu, Shen, Haihong

“…Clustered regularly-interspaced short palindromic repeats (CRISPR) is a new and effective genetic editing tool. CRISPR was initially found in bacteria to…”
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